ID   TDCA_SHIFL              Reviewed;         312 AA.
AC   P0ACQ9; P11036;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=HTH-type transcriptional regulator TdcA;
DE   AltName: Full=Tdc operon transcriptional activator;
GN   Name=tdcA; OrderedLocusNames=SF3158, S3370;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Transcriptional activator for the tdcABCDE operon.
CC       {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid degradation; L-threonine degradation via propanoate
CC       pathway [regulation].
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE005674; AAN44629.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18443.1; -; Genomic_DNA.
DR   RefSeq; NP_708922.1; NC_004337.2.
DR   RefSeq; WP_000104211.1; NZ_WPGW01000077.1.
DR   AlphaFoldDB; P0ACQ9; -.
DR   SMR; P0ACQ9; -.
DR   STRING; 198214.SF3158; -.
DR   EnsemblBacteria; AAN44629; AAN44629; SF3158.
DR   EnsemblBacteria; AAP18443; AAP18443; S3370.
DR   GeneID; 1027154; -.
DR   GeneID; 66672981; -.
DR   KEGG; sfl:SF3158; -.
DR   KEGG; sfx:S3370; -.
DR   PATRIC; fig|198214.7.peg.3748; -.
DR   HOGENOM; CLU_039613_6_0_6; -.
DR   OMA; PQTDMGY; -.
DR   OrthoDB; 990666at2; -.
DR   UniPathway; UPA00052; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0070689; P:L-threonine catabolic process to propionate; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..312
FT                   /note="HTH-type transcriptional regulator TdcA"
FT                   /id="PRO_0000105759"
FT   DOMAIN          7..64
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        24..43
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  34539 MW;  1ADD366D71ED68AB CRC64;
     MSTILLPKTQ HLVVFQEVIR SGSIGSAAKE LGLTQPAVSK IINDIEDYFG VELVVRKNTG
     VTLTPAGQLL LSRSESITRE MKNMVNEISG MSSEAVVEVS FGFPSLIGFT FMSGMINKFK
     EVFPKAQVSM YEAQLSSFLP AIRDGRLDFA IGTLSAEMKL QDLHVEPLFE SEFVLVASKS
     RTCTGTTTLE SLKNEQWVLP QTNMGYYSEL LTTLQRNGIS IENIVKTDSV VTIYNLVLNA
     DFLTVIPCDM TSPFGSNQFI TIPVEETLPV AQYAAVWSKN YRIKKAASVL VELAKEYSSY
     NGCRRRQLIE VG