ID   BR1VA_RANAR             Reviewed;          17 AA.
AC   P86159;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Brevinin-1AVa {ECO:0000303|PubMed:18280749};
OS   Rana arvalis (Moor frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=156871;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND DISULFIDE BOND.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:18280749};
RX   PubMed=18280749; DOI=10.1016/j.jasms.2007.12.010;
RA   Samgina T.Y., Artemenko K.A., Gorshkov V.A., Poljakov N.B., Lebedev A.T.;
RT   "Oxidation versus carboxamidomethylation of S-S bond in ranid frog
RT   peptides: pro and contra for de novo MALDI-MS sequencing.";
RL   J. Am. Soc. Mass Spectrom. 19:479-487(2008).
RN   [2]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISULFIDE
RP   BOND.
RC   TISSUE=Skin secretion;
RX   PubMed=19308951; DOI=10.1002/rcm.3994;
RA   Samgina T.Y., Artemenko K.A., Gorshkov V.A., Ogourtsov S.V., Zubarev R.A.,
RA   Lebedev A.T.;
RT   "Mass spectrometric study of peptides secreted by the skin glands of the
RT   brown frog Rana arvalis from the Moscow region.";
RL   Rapid Commun. Mass Spectrom. 23:1241-1248(2009).
CC   -!- FUNCTION: Antimicrobial peptide. {ECO:0000250|UniProtKB:P82826}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18280749,
CC       ECO:0000269|PubMed:19308951}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:18280749, ECO:0000269|PubMed:19308951}.
CC   -!- MASS SPECTROMETRY: Mass=1810.95; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18280749};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P86159; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..17
FT                   /note="Brevinin-1AVa"
FT                   /evidence="ECO:0000269|PubMed:18280749"
FT                   /id="PRO_0000371255"
FT   DISULFID        11..17
FT                   /evidence="ECO:0000269|PubMed:18280749,
FT                   ECO:0000269|PubMed:19308951"
SQ   SEQUENCE   17 AA;  1813 MW;  F56C9C74E9F397F3 CRC64;
     FLPLLAASFA CTVTKKC