ID   TDCC_ECOSM              Reviewed;         443 AA.
AC   B1LFL8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Threonine/serine transporter TdcC {ECO:0000255|HAMAP-Rule:MF_01583};
DE   AltName: Full=H(+)/threonine-serine symporter {ECO:0000255|HAMAP-Rule:MF_01583};
GN   Name=tdcC {ECO:0000255|HAMAP-Rule:MF_01583};
GN   OrderedLocusNames=EcSMS35_3412;
OS   Escherichia coli (strain SMS-3-5 / SECEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=439855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS-3-5 / SECEC;
RX   PubMed=18708504; DOI=10.1128/jb.00661-08;
RA   Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA   Ravel J., Stepanauskas R.;
RT   "Insights into the environmental resistance gene pool from the genome
RT   sequence of the multidrug-resistant environmental isolate Escherichia coli
RT   SMS-3-5.";
RL   J. Bacteriol. 190:6779-6794(2008).
CC   -!- FUNCTION: Involved in the import of threonine and serine into the cell,
CC       with the concomitant import of a proton (symport system).
CC       {ECO:0000255|HAMAP-Rule:MF_01583}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out);
CC         Xref=Rhea:RHEA:28883, ChEBI:CHEBI:15378, ChEBI:CHEBI:57926;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01583};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28885;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01583};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out);
CC         Xref=Rhea:RHEA:28887, ChEBI:CHEBI:15378, ChEBI:CHEBI:33384;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01583};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28889;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01583};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01583}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01583}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       SdaC/TdcC subfamily. {ECO:0000255|HAMAP-Rule:MF_01583}.
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DR   EMBL; CP000970; ACB16133.1; -; Genomic_DNA.
DR   RefSeq; WP_000107721.1; NC_010498.1.
DR   AlphaFoldDB; B1LFL8; -.
DR   SMR; B1LFL8; -.
DR   EnsemblBacteria; ACB16133; ACB16133; EcSMS35_3412.
DR   KEGG; ecm:EcSMS35_3412; -.
DR   HOGENOM; CLU_052043_1_1_6; -.
DR   OMA; SPQNMAE; -.
DR   Proteomes; UP000007011; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022889; F:serine transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015565; F:threonine efflux transmembrane transporter activity; IEA:InterPro.
DR   HAMAP; MF_01583; Thr_Ser_transp_TdcC; 1.
DR   InterPro; IPR018227; Amino_acid_transport_2.
DR   InterPro; IPR004694; Hydroxy_aa_transpt.
DR   InterPro; IPR023726; Thr/Ser_transpt_TdcC.
DR   PANTHER; PTHR35334:SF1; PTHR35334:SF1; 1.
DR   Pfam; PF03222; Trp_Tyr_perm; 1.
DR   TIGRFAMs; TIGR00814; stp; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..443
FT                   /note="Threonine/serine transporter TdcC"
FT                   /id="PRO_1000147632"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01583"
SQ   SEQUENCE   443 AA;  48893 MW;  B3BDFF795472F0AC CRC64;
     MSTSDSIVSS QTKQSSWRKS DTTWTLGLFG TAIGAGVLFF PIRAGFGGLI PILLMLVLAY
     PIAFYCHRAL ARLCLSGSNP SGNITETVEE HFGKTGGVVI TFLYFFAICP LLWIYGVTIT
     NTFMTFWENQ LGFAPLNRGF VALFLLLLMA FVIWFGKDLM VKVMSYLVWP FIASLVLISL
     SLIPYWNSAV IDQVDLGSLS LTGHDGILIT VWLGISIMVF SFNFSPIVSS FVVSKREEYE
     KDFGRDFTER KCSQIISRAS MLMVAVVMFF AFSCLFTLSP ANMAEAKAQN IPVLSYLANH
     FASMTGTKTT FAITLEYAAS IIALVAIFKS FFGHYLGTLE GLNGLILKFG YKGDKTKVSL
     GKLNTLSMIF IMGSTWVVAY ANPNILDLIE AMGAPIIASL LCLLPMYAIR KAPSLAKYRG
     RLDNVFVTVI GLLTILNIVY KLF