ID   TDHA_HAEDU              Reviewed;         739 AA.
AC   Q7VNU1; O87381;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=TonB-dependent heme receptor A;
DE   Flags: Precursor;
GN   Name=tdhA; OrderedLocusNames=HD_0388;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=35000HP / ATCC 700724;
RX   PubMed=9712775; DOI=10.1128/iai.66.9.4254-4262.1998;
RA   Thomas C.E., Olsen B., Elkins C.;
RT   "Cloning and characterization of tdhA, a locus encoding a TonB-dependent
RT   heme receptor from Haemophilus ducreyi.";
RL   Infect. Immun. 66:4254-4262(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Heme receptor. {ECO:0000269|PubMed:9712775}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Peripheral membrane protein.
CC   -!- INDUCTION: Expressed only under condition of low heme concentration.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AF052977; AAC35765.1; -; Genomic_DNA.
DR   EMBL; AE017143; AAP95357.1; -; Genomic_DNA.
DR   RefSeq; WP_010944410.1; NC_002940.2.
DR   AlphaFoldDB; Q7VNU1; -.
DR   SMR; Q7VNU1; -.
DR   STRING; 233412.HD_0388; -.
DR   PRIDE; Q7VNU1; -.
DR   EnsemblBacteria; AAP95357; AAP95357; HD_0388.
DR   KEGG; hdu:HD_0388; -.
DR   eggNOG; COG1629; Bacteria.
DR   HOGENOM; CLU_008287_19_3_6; -.
DR   OMA; PLFRPND; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Membrane; Receptor; Reference proteome; Signal;
KW   TonB box; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..739
FT                   /note="TonB-dependent heme receptor A"
FT                   /id="PRO_0000230229"
FT   CONFLICT        376
FT                   /note="Q -> P (in Ref. 1; AAC35765)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   739 AA;  84325 MW;  2C13319100640F22 CRC64;
     MKMKKQCATL TFFIGLHGYT IAEDNPKNIS LSVITVPGHH ERQPDRSIIT QNEIDQKQSD
     NVADLVNTVP GVSMAGGFRP SGQTLNIRGM GDTEDIRVQV DGATKNFEKY QQGSLFIEPE
     LLRRVSIDKG NHYPQYGNGG FAGTIKLETK NAKDFLQENQ LLGGLLKYGY NTNNNQRTFS
     GAIFMQNDQK NIDALVYATV RRAHDYKRAD KTPIKYSANN QANFLAKVNW WLTPSQLLAF
     SKVHGNHNGW EPFAAKRDLL PGPTEAEITK YGLDLAWKRK LVAREQQDRS YSLQYQFLPE
     NNPWINTVAQ LSHSSTYQHD TRSEQASKTY LASLGNESWT RYTDLTFDVN NTSLFNVAKT
     SHTLLVGLQW VKHKRQTLIF DPSKLQKAEY NHGYFQPSYM PSGHQYTHAF YAQDKIKIHN
     LTVSIGARYD YVKNIGKPNI ATIYNDPTAG HDYSSKHYPG WSSYLGLNYK LTPYLNLFSN
     ISNTWRAPVI DEQYETQYAK ATLSPTASSL DLKKERITQL RVGKQIHFDH ILSNNDQLSF
     NSTFFYYKGK DEIFKTRGVR CFESAQNNNN EVCSKKIGNY RNLPGYQIKG FELEANYDST
     YWFTNLSYSH TIGKRLASPR NPWLASTSWI AEIPPRKAVV TLGSHIPDTN LTLGWKSEFV
     RRQDRSPTDQ DKDAGHWALP KSSGYALHGI FATWQPKQIK HLRIQFTVDN LLNRSYRPYL
     SELAAGTGRN IKLSISKQF