ID   TDHA_HAEI8              Reviewed;         745 AA.
AC   Q4QP67;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=TonB-dependent heme receptor A;
DE   Flags: Precursor;
GN   Name=tdhA; Synonyms=hemR; OrderedLocusNames=NTHI0202;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Heme receptor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; CP000057; AAX87180.1; -; Genomic_DNA.
DR   RefSeq; WP_011271889.1; NC_007146.2.
DR   AlphaFoldDB; Q4QP67; -.
DR   SMR; Q4QP67; -.
DR   PRIDE; Q4QP67; -.
DR   EnsemblBacteria; AAX87180; AAX87180; NTHI0202.
DR   KEGG; hit:NTHI0202; -.
DR   HOGENOM; CLU_008287_19_3_6; -.
DR   OMA; PLFRPND; -.
DR   OrthoDB; 439303at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..745
FT                   /note="TonB-dependent heme receptor A"
FT                   /id="PRO_0000230230"
SQ   SEQUENCE   745 AA;  85228 MW;  B9650C96867D6764 CRC64;
     MNILINKRIF LLVTLVGIQL NVTAKQNSSN SNREELLPII VNTNDDSNKL PGRSVLKQKN
     IEQQQADNAA NLINILPGVN MAGGFRPGGQ TLNINGMGDA EDVRVQLDGA TKSFEKYQQG
     SIFIEPELLR RVTVDKGNYS PQYGNGGFAG TVKFETKAAR DFLQENQKIG GFLKYGNNSN
     NNQKTYSTAL VLQNEQKNID LLLFGSVRNA GDYKRPDNSK ILFSKNNQKT GLIKVNWQIS
     PEHLLTLSSV YGIHKGWEPF AAKRDILPKP SSGDIMRYGA DIAWKRKLVY RDQKDKNYTL
     KYNYLPENNP WINLSTQFSY SKTTQNDTRP EKAPPVFLGT LGNQSWITYS DLTFDINNTS
     TFNIKSTRHE LLFGLQWLKN TRNTLMYDKS KVKKEDYNYG YFQPYYMPSG RQYTQALYLQ
     DQITWKNIIF STGVRYDHIN NIGQKNFAPQ YNDISVGQNY SQKNYNGWSY YLGLKYDVNH
     YLSLFTNFSR TWRAPVIDEQ YETQYKQSSG PVTATSLNLE KEMINQTRVG GIITLNHLFQ
     ENDVFQFRTT YFYNRGKNEI FKTRGVNCVG NAADTNHVCP KIIGNYRNLP GYVIQGAELE
     AYYQSTYLFG EITYSYVKGK RDTSPRNPWG KTSTWIAEIP PRKATTALGF NIPKYNFTAG
     WRAEFVRRQD RSPLSGDPEA KYWSLPASRG YSLHNLFLSW SPAKIKGMNI KITVDNLFNR
     AYNPYLGELA SGTGRNIKFS LSQKF