ID   TDHA_HAEIN              Reviewed;         744 AA.
AC   P44523;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=TonB-dependent heme receptor A;
DE   Flags: Precursor;
GN   Name=tdhA; OrderedLocusNames=HI_0113;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Heme receptor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC21789.1; -; Genomic_DNA.
DR   PIR; B64049; B64049.
DR   RefSeq; NP_438287.1; NC_000907.1.
DR   RefSeq; WP_010868937.1; NC_000907.1.
DR   STRING; 71421.HI_0113; -.
DR   EnsemblBacteria; AAC21789; AAC21789; HI_0113.
DR   KEGG; hin:HI_0113; -.
DR   PATRIC; fig|71421.8.peg.117; -.
DR   eggNOG; COG1629; Bacteria.
DR   HOGENOM; CLU_008287_19_3_6; -.
DR   OMA; PLFRPND; -.
DR   PhylomeDB; P44523; -.
DR   BioCyc; HINF71421:G1GJ1-117-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Reference proteome; Signal;
KW   TonB box; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..744
FT                   /note="TonB-dependent heme receptor A"
FT                   /id="PRO_0000034762"
SQ   SEQUENCE   744 AA;  85044 MW;  74D94F72E41AEC31 CRC64;
     MNILINKRIF LLVTLVGIQL NVTAKQNSSN SNREELLPII VNTNDDSNKL PGRSVLKQKN
     IEQXQADNAA NLINILPGVN MAGGFRPGGQ TLNINGMGDA EDVRVQLDGA TKSFEKYQQG
     SIFIEPELLR RVTVDKGNYS PQYGNGGFAG TVKFETKDAR DFLQENQKIG GFLKYGNNSN
     NNQKTYSTAL VLQNEQKNID LLLFGSVRNA GDYKRPDNSK ILFSKNNQKT GLIKLNWQIS
     PEHLLTLSSV YGIHKGWEPF AAKRDILPKP SLSDIMRYGT DIAWKRKLVY RDQKDENYTL
     KYNYLPENNP WINLSTQFSY SKTTQNDMRP KEASSGLVGS LGNQSWITYS DLTFDINNTS
     TFNIKTTVHE LLFGLQWLKN TRNTLMYDKS KVRKADYNYG YFQPYYMPSG RQYTQAFYLQ
     DQIKWKNIIF STGVRYDHIN NIGQKNLALK YNDISAGHDY SQKNYNGWSY YLGLNYDVNH
     YLSLFTNFSK TWRAPVIDEQ YETQFKQSSV PATSLNLEKE MINQTRVGGI ITLNHLFQEN
     DAFQFRTTYF YNRGKNEIFK TRGVNCVGNA ADTNNKVCPK IIENYRNLPG YVIQGAELEA
     YYQSTYLFGE ITYSYVKGKR DTSPRNPWGK TSTWIAEIPP RKATTALGFN VPKYYLTVGW
     RAEFVRRQDR SPLSGDPKAS SWSLPASRGY SLHNLFLSWS PAKIKGMNVK ITVDNLFNRA
     YNPYLGELAS GTGRNIKFSL SQKF