ID   BR1_PELPV               Reviewed;          24 AA.
AC   P32423;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Brevinin-1;
OS   Pelophylax porosus brevipodus (Nagoya Daruma pond frog) (Rana brevipoda
OS   porosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=88447;
RN   [1]
RP   PROTEIN SEQUENCE, AND DISULFIDE BOND.
RC   TISSUE=Skin secretion;
RX   PubMed=1449472; DOI=10.1016/0006-291x(92)91542-x;
RA   Morikawa N., Hagiwara K., Nakajima T.;
RT   "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the
RT   frog, Rana brevipoda porsa.";
RL   Biochem. Biophys. Res. Commun. 189:184-190(1992).
CC   -!- FUNCTION: Shows antibacterial activity against representative Gram-
CC       negative and Gram-positive bacterial species, and a very high hemolytic
CC       activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   PIR; JC1355; JC1355.
DR   AlphaFoldDB; P32423; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR012520; Antimicrobial_frog_1.
DR   Pfam; PF08018; Antimicrobial_1; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW   Direct protein sequencing; Disulfide bond; Hemolysis; Secreted.
FT   PEPTIDE         1..24
FT                   /note="Brevinin-1"
FT                   /id="PRO_0000043539"
FT   DISULFID        18..24
FT                   /evidence="ECO:0000269|PubMed:1449472"
SQ   SEQUENCE   24 AA;  2531 MW;  C866285B191EFDF4 CRC64;
     FLPVLAGIAA KVVPALFCKI TKKC