BR2GA_SYLGU
ID BR2GA_SYLGU Reviewed; 34 AA.
AC P84860;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 25.
DE RecName: Full=Brevinin-2GHa;
DE AltName: Full=AMP-1;
OS Sylvirana guentheri (Gunther's frog) (Rana guentheri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Sylvirana.
OX NCBI_TaxID=110109;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DISULFIDE BOND, AND MASS SPECTROMETRY.
RC TISSUE=Skin secretion {ECO:0000269|PubMed:16979798};
RX PubMed=16979798; DOI=10.1016/j.peptides.2006.08.007;
RA Zhou J., McClean S., Thompson A., Zhang Y., Shaw C., Rao P., Bjourson A.J.;
RT "Purification and characterization of novel antimicrobial peptides from the
RT skin secretion of Hylarana guentheri.";
RL Peptides 27:3077-3084(2006).
CC -!- FUNCTION: Antimicrobial peptide. Active against the Gram-positive
CC bacteria S.aureus FDA209P (MIC=14.9 ug/ml) and B.subtilis ATCC 6633
CC (MIC>64 ug/ml), but not active against the Gram-negative bacterium
CC E.coli or the fungus C.albicans. {ECO:0000269|PubMed:16979798}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16979798}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:16979798}.
CC -!- MASS SPECTROMETRY: Mass=3415.2; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16979798};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000255}.
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DR AlphaFoldDB; P84860; -.
DR SMR; P84860; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Secreted.
FT PEPTIDE 1..34
FT /note="Brevinin-2GHa"
FT /evidence="ECO:0000269|PubMed:16979798"
FT /id="PRO_0000271185"
FT DISULFID 27..33
FT /evidence="ECO:0000269|PubMed:16979798"
SQ SEQUENCE 34 AA; 3417 MW; 9E20D12C7A5DE2DD CRC64;
GFSSLFKAGA KYLLKSVGKA GAQQLACKAA NNCA