ID   BR2HA_ODOHO             Reviewed;          33 AA.
AC   P0C8S9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Brevinin-2HSa;
OS   Odorrana hosii (Hose's rock frog) (Rana hosii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX   NCBI_TaxID=310666;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion;
RX   PubMed=18621071; DOI=10.1016/j.toxicon.2008.06.017;
RA   Conlon J.M., Kolodziejek J., Nowotny N., Leprince J., Vaudry H., Coquet L.,
RA   Jouenne T., King J.D.;
RT   "Characterization of antimicrobial peptides from the skin secretions of the
RT   Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).";
RL   Toxicon 52:465-473(2008).
CC   -!- FUNCTION: Has antibacterial activity against the Gram-positive
CC       bacterium S.aureus ATCC 25923 (MIC=18 uM) and the Gram-negative
CC       bacterium E.coli ATCC 25726 (MIC=36 uM). {ECO:0000269|PubMed:18621071}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- MASS SPECTROMETRY: Mass=3328.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18621071};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C8S9; -.
DR   SMR; P0C8S9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Brevinin-2HSa"
FT                   /id="PRO_0000366037"
FT   DISULFID        27..33
SQ   SEQUENCE   33 AA;  3333 MW;  FEA2A38280191F24 CRC64;
     GLLDSLKNLA INAAKGAGQS VLNTLSCKLS KTC