TDM1A_MOUSE
ID TDM1A_MOUSE Reviewed; 305 AA.
AC Q810U2; B9EJ62; Q2VP90;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Transmembrane epididymal protein 1A {ECO:0000312|MGI:MGI:2668439};
DE AltName: Full=Transmembrane epididymal protein 1-1 {ECO:0000312|EMBL:CAD86933.1};
GN Name=Teddm1a {ECO:0000312|MGI:MGI:2668439};
GN Synonyms=Epdd1, Teddm1 {ECO:0000312|EMBL:CAD86933.1},
GN Teddm1-1 {ECO:0000312|EMBL:CAD86933.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NMRI; TISSUE=Epididymis;
RA Davies B., Davies M., Obermann H., Spiess A.N., Kirchhoff C.;
RT "Novel epididymis-specific mRNAs down-regulated by HE6/Gpr64 receptor gene
RT disruption.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM45 family. {ECO:0000305}.
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DR EMBL; AJ554212; CAD86933.1; -; mRNA.
DR EMBL; BC109332; AAI09333.1; -; mRNA.
DR EMBL; BC141344; AAI41345.1; -; mRNA.
DR EMBL; BC141345; AAI41346.1; -; mRNA.
DR CCDS; CCDS15380.1; -.
DR RefSeq; NP_839975.2; NM_178244.3.
DR AlphaFoldDB; Q810U2; -.
DR SMR; Q810U2; -.
DR STRING; 10090.ENSMUSP00000062098; -.
DR GlyGen; Q810U2; 1 site.
DR PaxDb; Q810U2; -.
DR PRIDE; Q810U2; -.
DR ProteomicsDB; 262845; -.
DR GeneID; 240819; -.
DR KEGG; mmu:240819; -.
DR CTD; 240819; -.
DR MGI; MGI:2668439; Teddm1a.
DR eggNOG; ENOG502QS1R; Eukaryota.
DR InParanoid; Q810U2; -.
DR OrthoDB; 1297629at2759; -.
DR PhylomeDB; Q810U2; -.
DR BioGRID-ORCS; 240819; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q810U2; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q810U2; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006904; DUF716.
DR Pfam; PF04819; DUF716; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..305
FT /note="Transmembrane epididymal protein 1A"
FT /evidence="ECO:0000305"
FT /id="PRO_0000307130"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 285..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 119
FT /note="V -> M (in Ref. 2; AAI09333)"
FT /evidence="ECO:0000305"
FT CONFLICT 261
FT /note="P -> L (in Ref. 2; AAI09333)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 34794 MW; 17B5013E0B3A5538 CRC64;
MGDFIGHISP GLFLVFYGLY QAVIVSRAVI FNDSLLYPSY LSKNKGKWAR LWKIAHAGWL
KVVIGSLLIV YEISCVKEGL TLMTKGVPPR FMYPKEWQHL TMFFLLTLDG CVEMVSKNVL
RQRCVLLERG ATVLGVYVLL LLLVSHVKES SGVELQVHSL LILVVFLLML VLTAELWAPE
MFHLWMIETF LILIMGSWLI QAAFILFRPV SGFPWEDDDI SDIMFVTTFF CWHVMINALC
MLGIYGVSSF WHRCYSPSLR PMGSKEALYQ ESSSGTFYKL LQEAEQQDKD DQAPLLSKIS
PCDRA
