TDPC1_ARATH
ID TDPC1_ARATH Reviewed; 335 AA.
AC Q8RXZ9; Q9LIF7;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Mitochondrial thiamine diphosphate carrier 1 {ECO:0000305};
GN OrderedLocusNames=At3g21390 {ECO:0000312|Araport:AT3G21390};
GN ORFNames=MHC9.7 {ECO:0000312|EMBL:BAB03052.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15003237; DOI=10.1016/j.tplants.2004.01.007;
RA Picault N., Hodges M., Palmieri L., Palmieri F.;
RT "The growing family of mitochondrial carriers in Arabidopsis.";
RL Trends Plant Sci. 9:138-146(2004).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=22426856; DOI=10.1007/s10142-012-0273-4;
RA Frelin O., Agrimi G., Laera V.L., Castegna A., Richardson L.G.,
RA Mullen R.T., Lerma-Ortiz C., Palmieri F., Hanson A.D.;
RT "Identification of mitochondrial thiamin diphosphate carriers from
RT Arabidopsis and maize.";
RL Funct. Integr. Genomics 12:317-326(2012).
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC diphosphate (ThDP) into mitochondria. {ECO:0000269|PubMed:22426856}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:22426856}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000303|PubMed:15003237}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB03052.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AP001305; BAB03052.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002686; AEE76504.1; -; Genomic_DNA.
DR EMBL; AY122945; AAM67478.1; -; mRNA.
DR EMBL; AY080592; AAL85968.1; -; mRNA.
DR EMBL; AY087894; AAM65445.1; -; mRNA.
DR RefSeq; NP_566683.1; NM_113034.4.
DR AlphaFoldDB; Q8RXZ9; -.
DR SMR; Q8RXZ9; -.
DR STRING; 3702.AT3G21390.1; -.
DR PaxDb; Q8RXZ9; -.
DR PRIDE; Q8RXZ9; -.
DR ProteomicsDB; 226621; -.
DR EnsemblPlants; AT3G21390.1; AT3G21390.1; AT3G21390.
DR GeneID; 821693; -.
DR Gramene; AT3G21390.1; AT3G21390.1; AT3G21390.
DR KEGG; ath:AT3G21390; -.
DR Araport; AT3G21390; -.
DR TAIR; locus:2089453; AT3G21390.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_3_1; -.
DR InParanoid; Q8RXZ9; -.
DR PRO; PR:Q8RXZ9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8RXZ9; baseline and differential.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IGI:TAIR.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IGI:TAIR.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..335
FT /note="Mitochondrial thiamine diphosphate carrier 1"
FT /id="PRO_0000439893"
FT TRANSMEM 13..29
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TRANSMEM 88..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..199
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..323
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 13..111
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 124..210
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 232..329
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 335 AA; 36560 MW; D7691C32FCA2E445 CRC64;
MSGTELDEPG KLKRAVIDAS AGGVAGAISR MVTSPLDVIK IRFQVQLEPT ATWALKDSQL
KPKYNGLFRT TKDIFREEGL SGFWRGNVPA LLMVVPYTSI QFAVLHKVKS FAAGSSKAEN
HAQLSPYLSY ISGALAGCAA TVGSYPFDLL RTVLASQGEP KVYPNMRSAF LSIVQTRGIK
GLYAGLSPTL IEIIPYAGLQ FGTYDTFKRW SMVYNKRYRS SSSSSTNPSD SLSSFQLFLC
GLASGTVSKL VCHPLDVVKK RFQVEGLQRH PKYGARVELN AYKNMFDGLG QILRSEGWHG
LYKGIVPSTI KAAPAGAVTF VAYELASDWF EANLT
