TDPC1_MAIZE
ID TDPC1_MAIZE Reviewed; 336 AA.
AC B4FIJ0; A0A1D6G4V8; A0A1D6G4V9;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Mitochondrial thiamine diphosphate carrier 1 {ECO:0000305};
GN ORFNames=GRMZM2G118515 {ECO:0000303|PubMed:22426856},
GN ZEAMMB73_394006 {ECO:0000305}, Zm00001d011918 {ECO:0000312|EMBL:AQK98319.1,
GN ECO:0000312|EMBL:AQK98320.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=18937034; DOI=10.1007/s11103-008-9415-4;
RA Alexandrov N.N., Brover V.V., Freidin S., Troukhan M.E., Tatarinova T.V.,
RA Zhang H., Swaller T.J., Lu Y.-P., Bouck J., Flavell R.B., Feldmann K.A.;
RT "Insights into corn genes derived from large-scale cDNA sequencing.";
RL Plant Mol. Biol. 69:179-194(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22426856; DOI=10.1007/s10142-012-0273-4;
RA Frelin O., Agrimi G., Laera V.L., Castegna A., Richardson L.G.,
RA Mullen R.T., Lerma-Ortiz C., Palmieri F., Hanson A.D.;
RT "Identification of mitochondrial thiamin diphosphate carriers from
RT Arabidopsis and maize.";
RL Funct. Integr. Genomics 12:317-326(2012).
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC diphosphate (ThDP) into mitochondria. {ECO:0000269|PubMed:22426856}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:22426856}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Ubiquitous with highest expression in pollen.
CC {ECO:0000269|PubMed:22426856}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AQK98319.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AQK98320.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CM000784; AQK98319.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM000784; AQK98320.1; ALT_SEQ; Genomic_DNA.
DR EMBL; EU962778; ACG34896.1; -; mRNA.
DR EMBL; BT036928; ACF81933.1; -; mRNA.
DR RefSeq; NP_001132898.1; NM_001139426.1.
DR AlphaFoldDB; B4FIJ0; -.
DR SMR; B4FIJ0; -.
DR STRING; 4577.GRMZM2G118515_P01; -.
DR PaxDb; B4FIJ0; -.
DR EnsemblPlants; Zm00001eb363480_T002; Zm00001eb363480_P002; Zm00001eb363480.
DR GeneID; 100194395; -.
DR Gramene; Zm00001eb363480_T002; Zm00001eb363480_P002; Zm00001eb363480.
DR KEGG; zma:100194395; -.
DR eggNOG; KOG0752; Eukaryota.
DR OrthoDB; 1454699at2759; -.
DR Proteomes; UP000007305; Chromosome 8.
DR ExpressionAtlas; B4FIJ0; baseline and differential.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:CACAO.
DR GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IDA:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..336
FT /note="Mitochondrial thiamine diphosphate carrier 1"
FT /id="PRO_0000439895"
FT TRANSMEM 11..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TRANSMEM 88..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..199
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..322
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 11..111
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 124..210
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 231..328
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 336 AA; 37016 MW; F1ECFF48FC629027 CRC64;
MGSGEEPSQM RRALVDSLAG AISGGISRTV TSPLDVIKIR FQVQLEPTTS WGILRRDVYG
PSKYTGLLQA TKDILREEGL PGFWRGNVPA LFMYMPYTAI QFTVLHKLKT FASGSSRTED
HLDLSPYLSY VSGAIAGCTA TIGSYPFDLL RTILASQGEP KVYPNMRSAF IDIIKTRGVQ
GLYSGLSPTL VEIIPYAGLQ FGSYDTFKRS MMTWNRYKYS HLSFGSEDDS VSSFQLFLCG
FAAGTFSKAA CHPLDVVKKR FQIEGLKRHP RYGAPIESST YKGMYHALKE IVVKEGFGGL
YKGLFPSLVK SAPAGAVTFV VYEYISDWIG CKAGVE
