BR2PA_PULPI
ID BR2PA_PULPI Reviewed; 30 AA.
AC P0C8T3;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 21.
DE RecName: Full=Brevinin-2PTa;
OS Pulchrana picturata (Malaysian fire frog) (Hylarana picturata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pulchrana.
OX NCBI_TaxID=395594;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Skin secretion;
RX PubMed=18621071; DOI=10.1016/j.toxicon.2008.06.017;
RA Conlon J.M., Kolodziejek J., Nowotny N., Leprince J., Vaudry H., Coquet L.,
RA Jouenne T., King J.D.;
RT "Characterization of antimicrobial peptides from the skin secretions of the
RT Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).";
RL Toxicon 52:465-473(2008).
CC -!- FUNCTION: Has antibacterial activity against the Gram-positive
CC bacterium S.aureus ATCC 25923 (MIC=18 uM) and the Gram-negative
CC bacterium E.coli ATCC 25726 (MIC=18 uM). {ECO:0000269|PubMed:18621071}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC -!- MASS SPECTROMETRY: Mass=3125.3; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:18621071};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C8T3; -.
DR SMR; P0C8T3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR012521; Antimicrobial_frog_2.
DR Pfam; PF08023; Antimicrobial_2; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Secreted.
FT PEPTIDE 1..30
FT /note="Brevinin-2PTa"
FT /id="PRO_0000366041"
FT DISULFID 24..30
SQ SEQUENCE 30 AA; 3130 MW; A9885AE27F809E0A CRC64;
GAIKDALKGA AKTVAVELLK KAQCKLEKTC