TDPC2_ARATH
ID TDPC2_ARATH Reviewed; 339 AA.
AC Q9FI73;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Mitochondrial thiamine diphosphate carrier 2 {ECO:0000305};
GN OrderedLocusNames=At5g48970 {ECO:0000312|Araport:AT5G48970};
GN ORFNames=K19E20.10 {ECO:0000312|EMBL:BAB10321.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=15003237; DOI=10.1016/j.tplants.2004.01.007;
RA Picault N., Hodges M., Palmieri L., Palmieri F.;
RT "The growing family of mitochondrial carriers in Arabidopsis.";
RL Trends Plant Sci. 9:138-146(2004).
RN [6]
RP FUNCTION.
RX PubMed=22426856; DOI=10.1007/s10142-012-0273-4;
RA Frelin O., Agrimi G., Laera V.L., Castegna A., Richardson L.G.,
RA Mullen R.T., Lerma-Ortiz C., Palmieri F., Hanson A.D.;
RT "Identification of mitochondrial thiamin diphosphate carriers from
RT Arabidopsis and maize.";
RL Funct. Integr. Genomics 12:317-326(2012).
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC diphosphate (ThDP) into mitochondria. {ECO:0000269|PubMed:22426856}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:22426856}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000303|PubMed:15003237}.
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DR EMBL; AB017061; BAB10321.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95751.1; -; Genomic_DNA.
DR EMBL; AK117372; BAC42042.1; -; mRNA.
DR EMBL; BT006239; AAP12888.1; -; mRNA.
DR RefSeq; NP_199708.1; NM_124274.3.
DR AlphaFoldDB; Q9FI73; -.
DR SMR; Q9FI73; -.
DR STRING; 3702.AT5G48970.1; -.
DR PaxDb; Q9FI73; -.
DR PRIDE; Q9FI73; -.
DR ProteomicsDB; 232899; -.
DR DNASU; 834956; -.
DR EnsemblPlants; AT5G48970.1; AT5G48970.1; AT5G48970.
DR GeneID; 834956; -.
DR Gramene; AT5G48970.1; AT5G48970.1; AT5G48970.
DR KEGG; ath:AT5G48970; -.
DR Araport; AT5G48970; -.
DR TAIR; locus:2154374; AT5G48970.
DR eggNOG; KOG0752; Eukaryota.
DR HOGENOM; CLU_015166_10_3_1; -.
DR InParanoid; Q9FI73; -.
DR OMA; MYVCYGA; -.
DR OrthoDB; 1454699at2759; -.
DR PhylomeDB; Q9FI73; -.
DR PRO; PR:Q9FI73; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FI73; baseline and differential.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IGI:TAIR.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IGI:TAIR.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..339
FT /note="Mitochondrial thiamine diphosphate carrier 2"
FT /id="PRO_0000439894"
FT TRANSMEM 16..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TRANSMEM 93..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..155
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..204
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..252
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..327
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 16..116
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 129..215
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 236..333
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 339 AA; 37493 MW; 8A36F2C8D767150B CRC64;
MIPTTATVDD EPGQIKRALI DASAGAISGG VSRSVTSPLD VIKIRFQVQL EPTTSWGLVR
GNLSGASKYT GMVQATKDIF REEGFRGFWR GNVPALLMVM PYTSIQFTVL HKLKSFASGS
TKTEDHIHLS PYLSFVSGAL AGCAATLGSY PFDLLRTILA SQGEPKVYPT MRSAFVDIIQ
SRGIRGLYNG LTPTLVEIVP YAGLQFGTYD MFKRWMMDWN RYKLSSKIPI NVDTNLSSFQ
LFICGLGAGT SAKLVCHPLD VVKKRFQIEG LQRHPRYGAR VERRAYRNML DGLRQIMISE
GWHGLYKGIV PSTVKAAPAG AVTFVAYEFT SDWLESISW
