TDPC2_MAIZE
ID TDPC2_MAIZE Reviewed; 336 AA.
AC A0A1D6N272; A0A1D6N274; A0A1D6N275;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2016, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Mitochondrial thiamine diphosphate carrier 2 {ECO:0000305};
GN ORFNames=GRMZM2G124911 {ECO:0000303|PubMed:22426856},
GN Zm00001d042213 {ECO:0000312|EMBL:ONM34816.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22426856; DOI=10.1007/s10142-012-0273-4;
RA Frelin O., Agrimi G., Laera V.L., Castegna A., Richardson L.G.,
RA Mullen R.T., Lerma-Ortiz C., Palmieri F., Hanson A.D.;
RT "Identification of mitochondrial thiamin diphosphate carriers from
RT Arabidopsis and maize.";
RL Funct. Integr. Genomics 12:317-326(2012).
CC -!- FUNCTION: Mitochondrial transporter that mediates uptake of thiamine
CC diphosphate (ThDP) into mitochondria. {ECO:0000269|PubMed:22426856}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:22426856}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:22426856}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ONM34813.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ONM34814.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ONM34815.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ONM34817.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CM007649; ONM34813.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM007649; ONM34814.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM007649; ONM34815.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM007649; ONM34817.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM007649; ONM34816.1; -; Genomic_DNA.
DR RefSeq; XP_008674594.1; XM_008676372.1.
DR RefSeq; XP_008674595.1; XM_008676373.1.
DR AlphaFoldDB; A0A1D6N272; -.
DR SMR; A0A1D6N272; -.
DR STRING; 4577.GRMZM2G124911_P02; -.
DR EnsemblPlants; Zm00001eb142190_T002; Zm00001eb142190_P002; Zm00001eb142190.
DR GeneID; 103650800; -.
DR Gramene; Zm00001eb142190_T002; Zm00001eb142190_P002; Zm00001eb142190.
DR KEGG; zma:103650800; -.
DR eggNOG; KOG0752; Eukaryota.
DR OMA; MYVCYGA; -.
DR OrthoDB; 1454699at2759; -.
DR Proteomes; UP000007305; Chromosome 3.
DR ExpressionAtlas; A0A1D6N272; baseline and differential.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030974; P:thiamine pyrophosphate transmembrane transport; IDA:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..336
FT /note="Mitochondrial thiamine diphosphate carrier 2"
FT /id="PRO_0000439896"
FT TRANSMEM 11..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TRANSMEM 88..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..199
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..322
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 11..111
FT /note="Solcar 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 124..210
FT /note="Solcar 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 231..328
FT /note="Solcar 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 336 AA; 36974 MW; 771BAA2A0EC18B25 CRC64;
MGSGEEPSQM RRALVDSLAG AISGGISRTV TSPLDVIKIR FQVQLEPTTS WGILRRDIYG
PSKYTGLLQA TKDILREEGL PGFWRGNVPA LLMYMPYTAI QFTVLHKLKT FASGSSKTED
HLHLSPYLSY VSGALAGCAA TIGSYPFDLL RTILASQGEP KIYPNMRSAF VDIIKTRGVQ
GLYSGLSPTL VEIIPYAGLQ FGSYDTFKRS MMTWNRYKYS HLNFGSEDDS VSSFQLFLCG
FAAGTFSKAA CHPLDVVKKR FQIEGLKRHP RYGARIESST YKGMYHALKE IVAKEGFGGL
YKGLFPSLVK SAPAGAVTFV AYEYISDWIG SKAGVE
