TDPZ1_MOUSE
ID TDPZ1_MOUSE Reviewed; 365 AA.
AC P0DMR5; Q717B3; Q71G58; Q8BZV7; Q8VI39;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 07-JAN-2015, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=TD and POZ domain-containing protein 1 {ECO:0000305};
DE AltName: Full=MAPP family protein 2 {ECO:0000303|Ref.3};
GN Name=Tdpoz1 {ECO:0000312|MGI:MGI:2449436};
GN Synonyms=2cpoz56 {ECO:0000303|PubMed:11424210}, Mapp2,
GN Spopl1 {ECO:0000312|MGI:MGI:2449436};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL40187.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J X DBA/2 {ECO:0000312|EMBL:AAL40187.1};
RX PubMed=11424210; DOI=10.1002/mrd.1029;
RA Choo K.-B., Chen H.-H., Cheng W.T.K., Chang H.-S., Wang M.;
RT "In silico mining of EST databases for novel pre-implantation embryo-
RT specific zinc finger protein genes.";
RL Mol. Reprod. Dev. 59:249-255(2001).
RN [2] {ECO:0000312|EMBL:AAQ11977.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv {ECO:0000312|EMBL:AAQ11977.1};
RX PubMed=14693377; DOI=10.1016/j.gene.2003.09.022;
RA Huang C.-J., Chen C.-Y., Chen H.-H., Tsai S.-F., Choo K.-B.;
RT "TDPOZ, a family of bipartite animal and plant proteins that contain the
RT TRAF (TD) and POZ/BTB domains.";
RL Gene 324:117-127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RA Huang C.-J., Hong S.-Y., Chen H.-H., Choo K.-B.;
RT "MAPP: a novel and highly conserved family of proteins encompassing a MATH
RT and a POZ domains.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- DEVELOPMENTAL STAGE: Expressed in unfertilized eggs and pre-
CC implantation embryos. Undetectable in later-stage fetuses or in adult
CC tissues. {ECO:0000269|PubMed:11424210}.
CC -!- SIMILARITY: Belongs to the Tdpoz family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL40187.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF290198; AAL40187.1; ALT_INIT; mRNA.
DR EMBL; AF545858; AAQ11977.1; -; Genomic_DNA.
DR EMBL; AF506823; AAQ07947.1; -; Genomic_DNA.
DR CCDS; CCDS57231.1; -.
DR RefSeq; NP_683751.2; NM_148949.2.
DR AlphaFoldDB; P0DMR5; -.
DR SMR; P0DMR5; -.
DR STRING; 10090.ENSMUSP00000138008; -.
DR iPTMnet; P0DMR5; -.
DR PhosphoSitePlus; P0DMR5; -.
DR PaxDb; P0DMR5; -.
DR PRIDE; P0DMR5; -.
DR DNASU; 207213; -.
DR Ensembl; ENSMUST00000094413; ENSMUSP00000091980; ENSMUSG00000094084.
DR Ensembl; ENSMUST00000181541; ENSMUSP00000138008; ENSMUSG00000094084.
DR GeneID; 207213; -.
DR KEGG; mmu:207213; -.
DR UCSC; uc008qfm.2; mouse.
DR CTD; 207213; -.
DR MGI; MGI:2449436; Tdpoz1.
DR VEuPathDB; HostDB:ENSMUSG00000094084; -.
DR eggNOG; KOG1987; Eukaryota.
DR GeneTree; ENSGT00940000154376; -.
DR HOGENOM; CLU_004253_2_0_1; -.
DR OrthoDB; 864323at2759; -.
DR PhylomeDB; P0DMR5; -.
DR BioGRID-ORCS; 207213; 4 hits in 52 CRISPR screens.
DR PRO; PR:P0DMR5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P0DMR5; protein.
DR Bgee; ENSMUSG00000094084; Expressed in cleaving embryo and 1 other tissue.
DR Genevisible; P0DMR5; MM.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:MGI.
DR GO; GO:0000209; P:protein polyubiquitination; ISO:MGI.
DR GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR008974; TRAF-like.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00917; MATH; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50144; MATH; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..365
FT /note="TD and POZ domain-containing protein 1"
FT /id="PRO_0000191623"
FT DOMAIN 19..149
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT DOMAIN 188..250
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT CONFLICT 84
FT /note="I -> S (in Ref. 2; AAQ11977)"
FT /evidence="ECO:0000305"
FT CONFLICT 105..109
FT /note="IKSPT -> TKSPI (in Ref. 2; AAQ11977 and 3;
FT AAQ07947)"
FT /evidence="ECO:0000305"
FT CONFLICT 116..119
FT /note="NEQN -> YEQS (in Ref. 2; AAQ11977 and 3; AAQ07947)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="A -> V (in Ref. 2; AAQ11977)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="H -> Y (in Ref. 3; AAQ07947)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="L -> F (in Ref. 3; AAQ07947)"
FT /evidence="ECO:0000305"
FT CONFLICT 331..332
FT /note="IL -> MV (in Ref. 2; AAQ11977 and 3; AAQ07947)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="A -> T (in Ref. 2; AAQ11977)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 41584 MW; 7B23B4B58083AAFA CRC64;
MSEDMEFENW GSTQSSVEKF CYKWTISNFS FCMGGIQRRI TSPVFSSEEN KEVAWCLRVY
PKGADKESKD YLSVYLVLLS HLQIPVWAKF KFWIINSQGE KYQKIKSPTV ECFLTNEQNG
FKKFLPRDLL LSHRNCLLPE DQLTICCKVT ILGRKYNMPS QNITPAIKDP RHLLTDDLGE
LWENSLFTDC CLLVAGHEFR AHKAILAARS PVFRAMFEHE MKESLKTPIK IHNLNPQVFK
EMMGFIYTGK APHLHSHSMA CDVLPAADKY GLVSLKVLCE DALCRNLSVK NATHTLILAD
LHSTEKLKTQ ALDFIAYYAS EVCETSEWKS ILESHPHLVA EAFQSLASAQ CSFLEPKVIS
GSNQL
