TDPZ2_MOUSE
ID TDPZ2_MOUSE Reviewed; 364 AA.
AC Q717B2; B2RUE5; E9QNP4;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=TD and POZ domain-containing protein 2;
GN Name=Tdpoz2 {ECO:0000312|EMBL:AAQ11978.1}; Synonyms=Gm5773;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAQ11978.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=129/Sv {ECO:0000312|EMBL:AAQ11978.1};
RX PubMed=14693377; DOI=10.1016/j.gene.2003.09.022;
RA Huang C.-J., Chen C.-Y., Chen H.-H., Tsai S.-F., Choo K.-B.;
RT "TDPOZ, a family of bipartite animal and plant proteins that contain the
RT TRAF (TD) and POZ/BTB domains.";
RL Gene 324:117-127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- DEVELOPMENTAL STAGE: Not detected in any embryonic stages tested.
CC Weakly expressed in adult testis. {ECO:0000269|PubMed:14693377}.
CC -!- SIMILARITY: Belongs to the Tdpoz family. {ECO:0000305}.
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DR EMBL; AF545858; AAQ11978.1; -; Genomic_DNA.
DR EMBL; AC130840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC141104; AAI41105.1; -; mRNA.
DR AlphaFoldDB; Q717B2; -.
DR SMR; Q717B2; -.
DR STRING; 10090.ENSMUSP00000088366; -.
DR iPTMnet; Q717B2; -.
DR PhosphoSitePlus; Q717B2; -.
DR PaxDb; Q717B2; -.
DR PRIDE; Q717B2; -.
DR Ensembl; ENSMUST00000090853; ENSMUSP00000088366; ENSMUSG00000068879.
DR MGI; MGI:3027902; Tdpoz2.
DR VEuPathDB; HostDB:ENSMUSG00000068879; -.
DR eggNOG; KOG1987; Eukaryota.
DR GeneTree; ENSGT00940000154376; -.
DR HOGENOM; CLU_004253_2_0_1; -.
DR InParanoid; Q717B2; -.
DR OMA; YKIPIMP; -.
DR PhylomeDB; Q717B2; -.
DR TreeFam; TF313419; -.
DR PRO; PR:Q717B2; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q717B2; protein.
DR Bgee; ENSMUSG00000068879; Expressed in morula.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR008974; TRAF-like.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00917; MATH; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50144; MATH; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..364
FT /note="TD and POZ domain-containing protein 2"
FT /id="PRO_0000191624"
FT DOMAIN 19..149
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT DOMAIN 188..255
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT CONFLICT 48
FT /note="V -> E (in Ref. 1; AAQ11978 and 3; AAI41105)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="P -> H (in Ref. 1; AAQ11978 and 3; AAI41105)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="P -> S (in Ref. 1; AAQ11978 and 3; AAI41105)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="I -> F (in Ref. 1; AAQ11978 and 3; AAI41105)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="A -> V (in Ref. 1; AAQ11978 and 3; AAI41105)"
FT /evidence="ECO:0000305"
FT CONFLICT 228
FT /note="C -> Y (in Ref. 3; AAI41105)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="E -> D (in Ref. 1; AAQ11978 and 3; AAI41105)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="C -> H (in Ref. 1; AAQ11978 and 3; AAI41105)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 41537 MW; DAA4767F9E580F7C CRC64;
MSGDMEAKIW GSTQISVKEF CYEWTISNFS FCMGGIRRKI KSPVFSLVAN EEVAWCLRVH
PNGFDEESKD YLSVYLVLVN CPKRQVRAKF EFWIKNSQGE KYQYTQSLNV PSFQRKQNWG
FSKFILRDSL LSHRNWLLPK DKLTLCCKVS IVGAILNMPG QNMIPAIKDP RHMLTDDLGK
LWENPLFTDC SLLVAGHEIR AHKAILAARS PVFRAMFEHQ MEERLANCFE IQELDFQVFK
EMMDFIYTGK APTLHSHSMA CDVLAAAEKY GLEGLKVICE DSLCRNLSVE NAAHTLIVAD
LHSTEQLKTR ALHFIAVHAS EVSKSSGWKS MVESHPHLVD ERFHSLASAQ SVFLESSFKC
LKGF
