TDPZ3_MOUSE
ID TDPZ3_MOUSE Reviewed; 365 AA.
AC Q717B4; E9QKH5;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=TD and POZ domain-containing protein 3;
GN Name=Tdpoz3 {ECO:0000312|EMBL:AAQ11976.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAQ11976.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=129/Sv {ECO:0000312|EMBL:AAQ11976.1};
RX PubMed=14693377; DOI=10.1016/j.gene.2003.09.022;
RA Huang C.-J., Chen C.-Y., Chen H.-H., Tsai S.-F., Choo K.-B.;
RT "TDPOZ, a family of bipartite animal and plant proteins that contain the
RT TRAF (TD) and POZ/BTB domains.";
RL Gene 324:117-127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- DEVELOPMENTAL STAGE: Strongly expressed in 2-cell embryos with weak
CC expression detected in other embryonic stages. Also weakly expressed in
CC adult testis. {ECO:0000269|PubMed:14693377}.
CC -!- SIMILARITY: Belongs to the Tdpoz family. {ECO:0000305}.
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DR EMBL; AF545857; AAQ11976.1; -; Genomic_DNA.
DR EMBL; AC170911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS17586.1; -.
DR RefSeq; NP_997154.2; NM_207271.2.
DR AlphaFoldDB; Q717B4; -.
DR SMR; Q717B4; -.
DR BioGRID; 240010; 3.
DR STRING; 10090.ENSMUSP00000080472; -.
DR iPTMnet; Q717B4; -.
DR PhosphoSitePlus; Q717B4; -.
DR PaxDb; Q717B4; -.
DR PRIDE; Q717B4; -.
DR DNASU; 399674; -.
DR Ensembl; ENSMUST00000081780; ENSMUSP00000080472; ENSMUSG00000058005.
DR GeneID; 399674; -.
DR KEGG; mmu:399674; -.
DR UCSC; uc008qfo.1; mouse.
DR CTD; 399674; -.
DR MGI; MGI:3027903; Tdpoz3.
DR VEuPathDB; HostDB:ENSMUSG00000058005; -.
DR eggNOG; KOG1987; Eukaryota.
DR GeneTree; ENSGT00940000154376; -.
DR HOGENOM; CLU_004253_2_0_1; -.
DR InParanoid; Q717B4; -.
DR OMA; CYNWTIS; -.
DR OrthoDB; 864323at2759; -.
DR PhylomeDB; Q717B4; -.
DR TreeFam; TF313419; -.
DR BioGRID-ORCS; 399674; 10 hits in 70 CRISPR screens.
DR PRO; PR:Q717B4; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q717B4; protein.
DR Bgee; ENSMUSG00000058005; Expressed in duodenum.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:MGI.
DR GO; GO:0000209; P:protein polyubiquitination; ISO:MGI.
DR GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR008974; TRAF-like.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50144; MATH; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..365
FT /note="TD and POZ domain-containing protein 3"
FT /id="PRO_0000191625"
FT DOMAIN 19..149
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT DOMAIN 188..250
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT CONFLICT 134
FT /note="M -> Q (in Ref. 1; AAQ11976)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="V -> G (in Ref. 1; AAQ11976)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="E -> D (in Ref. 1; AAQ11976)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="N -> H (in Ref. 1; AAQ11976)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="T -> N (in Ref. 1; AAQ11976)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="D -> E (in Ref. 1; AAQ11976)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 41521 MW; F97FBAFEA1EEBB02 CRC64;
MAGDMEFKSW GYTQINVQKF CYNWTISNFS FCMGAHQKSI TSPVFSLEAS KEVAWCLRLY
PNGVDEESKD YLSVYLELLS ALESPILAKF EFWIINSQGE KYQSRKISNV QCFLQYEHRG
FKKFLLRGLL LSHMNWFLPE DQFTICCKVS IVGTVFDMPV QKRTPAIKDP RHMLTDDLGE
LWENSLFTDC CLLVAGHEFK AHKAILAARS PVFRAMFENE MKESLKNPIE IMDLDLDVFK
EMMGFIYTGK APHLHSHSMA CDVLPAADKY GLVGLKVLCE DVLCRNLSVK TAAHTLILAD
LNSTEKLKSQ ALDFIAIHAC EVSETSEWKS MWKSHPHLVA EAFHSLASAK CSFLEPNVVL
ESSQL
