TDPZ4_MOUSE
ID TDPZ4_MOUSE Reviewed; 370 AA.
AC Q6YCH2; E9QJY8; Q14BT0;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=TD and POZ domain-containing protein 4;
GN Name=Tdpoz4 {ECO:0000312|EMBL:AAO20102.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAO20102.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=129/Sv {ECO:0000312|EMBL:AAO20102.1};
RX PubMed=14693377; DOI=10.1016/j.gene.2003.09.022;
RA Huang C.-J., Chen C.-Y., Chen H.-H., Tsai S.-F., Choo K.-B.;
RT "TDPOZ, a family of bipartite animal and plant proteins that contain the
RT TRAF (TD) and POZ/BTB domains.";
RL Gene 324:117-127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- DEVELOPMENTAL STAGE: Strongly expressed in 2-cell embryos. No
CC expression detected in other embryonic stages or in adult testis.
CC {ECO:0000269|PubMed:14693377}.
CC -!- SIMILARITY: Belongs to the Tdpoz family. {ECO:0000305}.
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DR EMBL; AY159314; AAO20102.1; -; Genomic_DNA.
DR EMBL; AC130840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115626; AAI15627.1; -; mRNA.
DR CCDS; CCDS38528.1; -.
DR RefSeq; NP_997155.2; NM_207272.2.
DR AlphaFoldDB; Q6YCH2; -.
DR SMR; Q6YCH2; -.
DR STRING; 10090.ENSMUSP00000075338; -.
DR PaxDb; Q6YCH2; -.
DR PRIDE; Q6YCH2; -.
DR DNASU; 399675; -.
DR Ensembl; ENSMUST00000075953; ENSMUSP00000075338; ENSMUSG00000060256.
DR GeneID; 399675; -.
DR KEGG; mmu:399675; -.
DR UCSC; uc008qfn.1; mouse.
DR CTD; 399675; -.
DR MGI; MGI:3027904; Tdpoz4.
DR VEuPathDB; HostDB:ENSMUSG00000060256; -.
DR eggNOG; KOG1987; Eukaryota.
DR GeneTree; ENSGT00940000154376; -.
DR HOGENOM; CLU_004253_2_0_1; -.
DR InParanoid; Q6YCH2; -.
DR OMA; EPEENNR; -.
DR OrthoDB; 864323at2759; -.
DR PhylomeDB; Q6YCH2; -.
DR TreeFam; TF313419; -.
DR BioGRID-ORCS; 399675; 4 hits in 70 CRISPR screens.
DR PRO; PR:Q6YCH2; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q6YCH2; protein.
DR Bgee; ENSMUSG00000060256; Expressed in morula and 2 other tissues.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:MGI.
DR GO; GO:0000209; P:protein polyubiquitination; ISO:MGI.
DR GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR008974; TRAF-like.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50144; MATH; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..370
FT /note="TD and POZ domain-containing protein 4"
FT /id="PRO_0000191626"
FT DOMAIN 19..149
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT DOMAIN 188..251
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT CONFLICT 12
FT /note="D -> H (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
FT CONFLICT 23
FT /note="R -> S (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="L -> P (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="N -> D (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="E -> Q (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="E -> K (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="M -> K (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
FT CONFLICT 286
FT /note="S -> N (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
FT CONFLICT 307
FT /note="L -> V (in Ref. 1; AAO20102 and 3; AAI15627)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 370 AA; 42196 MW; 4B5AF06406D8405A CRC64;
MSGELEAKSR GDTQSHEQKL CYRWTISNFS FFVEETEEYI TSLVFSLEDN DKMTWCLRVY
PTGVDEKNKD YVSLYLILLS CEKGSVWAKF EVCILNAKGE KCNTERIPSF SRIQPHQPFG
FEKFITRDSF LSPAQVLTPD DKFTLLCKVS VLQDSFSISG QNPRPAIKVT RCTLENDVGE
LWENPLFTDC SLLVAGHEFR AHKAILAARS PVFRAMFEHE MEERLTNCVE IHDLDPQVFK
EMMGFIYTGK VPHLHSHSMA CDLLAAADRY GLEDLMVMCE DALCRSLSVE NAAHTLIVAD
LHSTEHLKTQ ALDFIIVYAS EVSKTSGWMS MVESHPRLVA EAFHSLASAQ RVFWALPFKQ
LKWSLRPTQL
