TDR10_HUMAN
ID TDR10_HUMAN Reviewed; 366 AA.
AC Q5VZ19; A4FU09; B0QZ53; B4DXV4; Q3ZCP1; Q3ZCS7; Q5SXY7; Q6UXV2; Q8TCN3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Tudor domain-containing protein 10;
GN Name=TDRD10; ORFNames=UNQ9380/PRO34205;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ILE-215.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 96-357 (ISOFORM 1), AND VARIANT ILE-215.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 86-366 (ISOFORM 1), AND VARIANT
RP ILE-215.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 132-366 (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5VZ19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VZ19-2; Sequence=VSP_022216;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH44864.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI00896.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI00897.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI00898.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI00899.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAQ88562.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAD28538.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK302144; BAG63516.1; -; mRNA.
DR EMBL; AL162591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL592078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC044864; AAH44864.1; ALT_INIT; mRNA.
DR EMBL; BC100895; AAI00896.1; ALT_INIT; mRNA.
DR EMBL; BC100896; AAI00897.1; ALT_INIT; mRNA.
DR EMBL; BC100897; AAI00898.1; ALT_INIT; mRNA.
DR EMBL; BC100898; AAI00899.1; ALT_INIT; mRNA.
DR EMBL; AL713777; CAD28538.1; ALT_FRAME; mRNA.
DR EMBL; AY358195; AAQ88562.1; ALT_INIT; mRNA.
DR CCDS; CCDS30878.2; -. [Q5VZ19-2]
DR CCDS; CCDS41406.1; -. [Q5VZ19-1]
DR RefSeq; NP_001091945.1; NM_001098475.1. [Q5VZ19-1]
DR RefSeq; NP_872305.3; NM_182499.3. [Q5VZ19-2]
DR RefSeq; XP_006711219.1; XM_006711156.2.
DR RefSeq; XP_011507462.1; XM_011509160.2.
DR RefSeq; XP_011507463.1; XM_011509161.1.
DR AlphaFoldDB; Q5VZ19; -.
DR BioGRID; 126008; 3.
DR STRING; 9606.ENSP00000357465; -.
DR iPTMnet; Q5VZ19; -.
DR PhosphoSitePlus; Q5VZ19; -.
DR BioMuta; TDRD10; -.
DR DMDM; 239938838; -.
DR EPD; Q5VZ19; -.
DR MassIVE; Q5VZ19; -.
DR PaxDb; Q5VZ19; -.
DR PeptideAtlas; Q5VZ19; -.
DR PRIDE; Q5VZ19; -.
DR ProteomicsDB; 65664; -. [Q5VZ19-1]
DR ProteomicsDB; 65665; -. [Q5VZ19-2]
DR Antibodypedia; 34154; 8 antibodies from 7 providers.
DR DNASU; 126668; -.
DR Ensembl; ENST00000368480.3; ENSP00000357465.3; ENSG00000163239.12. [Q5VZ19-1]
DR Ensembl; ENST00000368482.8; ENSP00000357467.4; ENSG00000163239.12. [Q5VZ19-2]
DR GeneID; 126668; -.
DR KEGG; hsa:126668; -.
DR MANE-Select; ENST00000368482.8; ENSP00000357467.4; NM_182499.4; NP_872305.3. [Q5VZ19-2]
DR UCSC; uc001ffd.3; human. [Q5VZ19-1]
DR CTD; 126668; -.
DR DisGeNET; 126668; -.
DR GeneCards; TDRD10; -.
DR HGNC; HGNC:25316; TDRD10.
DR HPA; ENSG00000163239; Tissue enriched (testis).
DR neXtProt; NX_Q5VZ19; -.
DR OpenTargets; ENSG00000163239; -.
DR PharmGKB; PA142670823; -.
DR VEuPathDB; HostDB:ENSG00000163239; -.
DR eggNOG; ENOG502QWDW; Eukaryota.
DR GeneTree; ENSGT00390000006620; -.
DR HOGENOM; CLU_069836_0_0_1; -.
DR InParanoid; Q5VZ19; -.
DR OMA; CLSMESH; -.
DR OrthoDB; 1361661at2759; -.
DR PhylomeDB; Q5VZ19; -.
DR TreeFam; TF343710; -.
DR PathwayCommons; Q5VZ19; -.
DR BioGRID-ORCS; 126668; 10 hits in 1065 CRISPR screens.
DR GenomeRNAi; 126668; -.
DR Pharos; Q5VZ19; Tdark.
DR PRO; PR:Q5VZ19; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VZ19; protein.
DR Bgee; ENSG00000163239; Expressed in left testis and 116 other tissues.
DR Genevisible; Q5VZ19; HS.
DR GO; GO:0043186; C:P granule; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030719; P:P granule organization; IBA:GO_Central.
DR GO; GO:0034587; P:piRNA metabolic process; IBA:GO_Central.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; RNA-binding.
FT CHAIN 1..366
FT /note="Tudor domain-containing protein 10"
FT /id="PRO_0000270754"
FT DOMAIN 34..107
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 210..317
FT /note="Tudor"
FT COILED 216..237
FT /evidence="ECO:0000255"
FT VAR_SEQ 342..366
FT /note="VTAPASNLAVVPPLLPLGCLQQAAA -> LHILKFEESK (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022216"
FT VARIANT 181
FT /note="R -> Q (in dbSNP:rs12750774)"
FT /id="VAR_029817"
FT VARIANT 215
FT /note="V -> I (in dbSNP:rs3811448)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_029818"
FT CONFLICT 93
FT /note="K -> N (in Ref. 4; CAD28538)"
FT /evidence="ECO:0000305"
FT CONFLICT 297
FT /note="S -> Q (in Ref. 4; CAD28538)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 366 AA; 40941 MW; 0CA48444B9FF6F49 CRC64;
MSWNISHPQL SDKLFGKNGV LEEQKSPGFK KRETEVYVGN LPLDISKEEI LYLLKDFNPL
DVHKIQNGCK CFAFVDLGSM QKVTLAIQEL NGKLFHKRKL FVNTSKRPPK RTPDMIQQPR
APLVLEKASG EGFGKTAAII QLAPKAPVDL CETEKLRAAF FAVPLEMRGS FLVLLLRECF
RDLSWLALIH SVRGEAGLLV TSIVPKTPFF WAMHVTEALH QNMQALFSTL AQAEEQQPYL
EGSTVMRGTR CLAEYHLGDY GHAWNRCWVL DRVDTWAVVM FIDFGQLATI PVQSLRSLDS
DDFWTIPPLT QPFMLEKDIL SSYEVVHRIL KGKITGALNS AVTAPASNLA VVPPLLPLGC
LQQAAA
