TDR15_HUMAN
ID TDR15_HUMAN Reviewed; 1934 AA.
AC B5MCY1;
DT 03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Tudor domain-containing protein 15;
GN Name=TDRD15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-105.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AC010872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EG328743; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS77385.1; -.
DR RefSeq; NP_001293066.1; NM_001306137.1.
DR RefSeq; XP_011531514.1; XM_011533212.1.
DR AlphaFoldDB; B5MCY1; -.
DR STRING; 9606.ENSP00000384376; -.
DR iPTMnet; B5MCY1; -.
DR PhosphoSitePlus; B5MCY1; -.
DR BioMuta; TDRD15; -.
DR EPD; B5MCY1; -.
DR MassIVE; B5MCY1; -.
DR PaxDb; B5MCY1; -.
DR PeptideAtlas; B5MCY1; -.
DR PRIDE; B5MCY1; -.
DR Antibodypedia; 64488; 9 antibodies from 5 providers.
DR Ensembl; ENST00000405799.3; ENSP00000384376.2; ENSG00000218819.6.
DR Ensembl; ENST00000622654.1; ENSP00000478350.1; ENSG00000218819.6.
DR GeneID; 100129278; -.
DR KEGG; hsa:100129278; -.
DR MANE-Select; ENST00000405799.3; ENSP00000384376.2; NM_001306137.2; NP_001293066.1.
DR UCSC; uc061gzs.1; human.
DR CTD; 100129278; -.
DR GeneCards; TDRD15; -.
DR HGNC; HGNC:45037; TDRD15.
DR HPA; ENSG00000218819; Tissue enriched (testis).
DR neXtProt; NX_B5MCY1; -.
DR OpenTargets; ENSG00000218819; -.
DR VEuPathDB; HostDB:ENSG00000218819; -.
DR eggNOG; KOG2039; Eukaryota.
DR GeneTree; ENSGT00940000162581; -.
DR HOGENOM; CLU_001126_2_0_1; -.
DR InParanoid; B5MCY1; -.
DR OMA; YIHYSEI; -.
DR OrthoDB; 496838at2759; -.
DR PhylomeDB; B5MCY1; -.
DR PathwayCommons; B5MCY1; -.
DR SignaLink; B5MCY1; -.
DR BioGRID-ORCS; 100129278; 0 hits in 133 CRISPR screens.
DR GenomeRNAi; 100129278; -.
DR Pharos; B5MCY1; Tdark.
DR PRO; PR:B5MCY1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; B5MCY1; protein.
DR Bgee; ENSG00000218819; Expressed in testis and 9 other tissues.
DR GO; GO:0043186; C:P granule; IBA:GO_Central.
DR GO; GO:0030719; P:P granule organization; IBA:GO_Central.
DR GO; GO:0034587; P:piRNA metabolic process; IBA:GO_Central.
DR CDD; cd04508; TUDOR; 7.
DR Gene3D; 2.40.50.90; -; 6.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF00567; TUDOR; 8.
DR SMART; SM00333; TUDOR; 8.
DR SUPFAM; SSF50199; SSF50199; 1.
DR PROSITE; PS50304; TUDOR; 6.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..1934
FT /note="Tudor domain-containing protein 15"
FT /id="PRO_0000421965"
FT DOMAIN 59..117
FT /note="Tudor 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 289..347
FT /note="Tudor 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 531..589
FT /note="Tudor 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 799..856
FT /note="Tudor 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1011..1070
FT /note="Tudor 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1342..1401
FT /note="Tudor 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1574..1633
FT /note="Tudor 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 1780..1838
FT /note="Tudor 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT REGION 1490..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1934 AA; 221722 MW; 51FCD0252E2D0C29 CRC64;
MDSTSFLPTF LDVDLTISHI KCLPKDILVK FQGIKSNECE FDYHVLQREI QHTPKVKNNV
EIDEFCLVEE RVSGEWQRGR VMEKKNELYT VLLIDRGEEL RVAGPQIASA CGNLFELPPR
VVFGIFANIL PVGEKWSPKA LNYFKSLVGI QVKGYVQAIL PLQMFLFEVP KIISQALELQ
LGRLVDGDSF RLIVEMLEEF PQQMPDLLQH KRPELSLGNK DTSLDIQHVL DKLQPSLSVG
STESVKVSSA LSPSKFYCQL IKWTPELENL TAHMTLHYDT VCQETSPTCD NFGLLCVARR
RNGQWHRGIL QQLLPPNQVK IWFMDYGSSE AIPSIYVKKL KQDFILVPLF SFPCSLTCLH
SPDRDARIFQ LSIFKQALLG QVVYAHIDWF NKDECLYYVT LQTQESTVNS KCLLKTVGTQ
VLCPMSDSKI SNILSETSVS DVNSFAVESF MGNIEWSIDS LNKKGILKVG FPIKTVQMEI
EAAYIAFIAY VLNPSNFWVR TNDHRNEFQE IMKNINKFYD LCENDEMILR KPEPGLFCCA
RYSKDRRFYR AVITEINGYK INVYFLDYGN TDSIPFFDVK ILLPEFCELP ALAMCCSLAH
IFPVEDLWTK AAIDYFKKLV LNKAILLQVI AKKDDKYTVN IQSVEASENI DVISLMLQAG
YAEYFQVELE YFPKSVSEYS MLNSESKNKV NIKKVISALL EGPKSKKYHS NNLVENNLSL
PKSLAVNISE FKNPFTLSVG PESSWPYKEY IFRPGTVLEV KCSCYYGPGD FSCQLQCKSE
DLKLLMEQIQ NYYSIHSDPY EIGQTACVAK YSGKWCRAAV LTQVSKEVDI VFVDYGYQKR
VLIEDLCAIN PRFLLLESQA FRCCLNHFIE PVSCKLFSWT RKAFRDLWNF ISSSRGLLTC
IIYALVIIHP NHLYNLVDLQ SSFTSAKEFL MNRGSAQYIT LSETFPSLFS LYSYCYSSFN
IQIGSEEEVY ISHIYSPQKF YCQLGRNNKD LEMIETKITE SVNLQNFPKY DSNKMRVCIS
KYVEDGLSYR ALAIPTDSSS EFQVYFVDFG NKQLVGENML RAISAQFPEL LFTPMQAIKC
FLSDLRDVDI PAEISSWFKD NFLGRSLKAI ILSQESDGQL GIELYDGSQY INEKIKVLLH
AYGKRHCDQA CCMEKSNKIN ENKRFTTSLK GKTGNNYRHN VINKPSPVTY SERKIDQLMH
PKNIHARFLK PSVCYKMEPV SKNKMKTSLN DGLKGIKIVP GAAHILENRR VGQKSVKVVS
QSFIRALNQT TSQNPYDLIR PQIKDLPQPQ IYLNAKVKGY VSNISNPANF HIQLAENESV
IIRLADALNA TARRLRERKS VKPLVGDLVV AEYSGDNAIY RAVIKKILPG NSFEVEFIDY
GNSAIVNTSK IYELQREFLT VPQLGIHAFL SGVKWNEPDE IWDDKTVDYF TSKVHNKTVY
CEFLKKHDQK WEVNMICDEK CVINELLKWK ACSKLQKSAL QMPQVLSQKV RPGDNEMKKG
KSNESEGSMN SNQQLFKIPL EEFKLGQLEK AEMLNVSKSG RFYVKLSKNK KILSDLIVLI
TKEEKKSPFL SMESIEKGLE CLAKSKNTLK WHRSKVEEKY VDDKVLVFLV DCGIYEIVPV
CNTKLLSNEI RNIPRQAVPC KWIWFENSKN ISFECLFADL EINILFLKYL DAVWEVEILV
DDLLLLEYLN LNTVPVEENK LRLAEIVYNI ESKTPVSSCT IKSFTWVQFQ NDRQYSGIAT
AVSDPSDFSI QLEDFFDIMK YLFMLLSDLP ETLQTLPQEF IIPGSSCLFK YKSEDQWNRV
EISEVSPQSL CLVLVDYGFS FYIRYSEIIN LKVVPEELLN LPRLSYPCIL YGILPAKGKH
WSEEAKIFFR DFLSKPDLVF QFREYHSETK LKVDVIHEKN NLADILVASG LATYSKDSPH
LDAITATESA KNPI
