ID   TDRD5_AILME             Reviewed;         982 AA.
AC   D2H3M0;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Tudor domain-containing protein 5;
GN   Name=TDRD5; ORFNames=PANDA_004307;
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
CC   -!- FUNCTION: Required during spermiogenesis to participate in the
CC       repression transposable elements and prevent their mobilization, which
CC       is essential for the germline integrity. Probably acts via the piRNA
CC       metabolic process, which mediates the repression of transposable
CC       elements during meiosis by forming complexes composed of piRNAs and
CC       Piwi proteins and govern the methylation and subsequent repression of
CC       transposons. Required for chromatoid body (CB) assembly (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to
CC       chromatoid body (CB) and pi-body (also called intermitochondrial
CC       cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA
CC       processing for spermatogenesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDRD5 family. {ECO:0000305}.
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DR   EMBL; GL192465; EFB26879.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2H3M0; -.
DR   SMR; D2H3M0; -.
DR   STRING; 9646.ENSAMEP00000015531; -.
DR   PRIDE; D2H3M0; -.
DR   eggNOG; KOG2039; Eukaryota.
DR   InParanoid; D2H3M0; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0033391; C:chromatoid body; ISS:UniProtKB.
DR   GO; GO:0071546; C:pi-body; ISS:UniProtKB.
DR   GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
DR   GO; GO:0030719; P:P granule organization; ISS:UniProtKB.
DR   GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR   CDD; cd09975; LOTUS_2_TDRD5; 1.
DR   CDD; cd04508; TUDOR; 1.
DR   Gene3D; 2.40.50.90; -; 1.
DR   Gene3D; 3.30.420.610; -; 3.
DR   InterPro; IPR041966; LOTUS-like.
DR   InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR037982; TDRD5_LOTUS_2.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF12872; OST-HTH; 3.
DR   Pfam; PF00567; TUDOR; 1.
DR   SMART; SM00333; TUDOR; 1.
DR   PROSITE; PS51644; HTH_OST; 3.
DR   PROSITE; PS50304; TUDOR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Differentiation; Phosphoprotein;
KW   Reference proteome; Repeat; Spermatogenesis.
FT   CHAIN           1..982
FT                   /note="Tudor domain-containing protein 5"
FT                   /id="PRO_0000408345"
FT   DOMAIN          7..80
FT                   /note="HTH OST-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          127..202
FT                   /note="HTH OST-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          297..371
FT                   /note="HTH OST-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          527..586
FT                   /note="Tudor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   REGION          816..838
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          882..912
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        817..837
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        898..912
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         894
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5VCS6"
SQ   SEQUENCE   982 AA;  109911 MW;  8C35DCD9B0B4D389 CRC64;
     MSEQERVQEC LRKEIRSLLI STKDGLTPQQ LEKEYLLMVG SHLPLRILGY RSTMELVLDM
     PDVVTVCPYG DGTVILRAIP DESTKGIASL VAKQRSSHKV RNSAQKGRAS VCSGPSSRRQ
     VPYRGRLPPI LPAVVKSELK DLLALSPILL SDFEKAFVRR FGRSFQYVQY GFFSMFEVLN
     AASDVISVEQ TRAGSLLMLK KSVSEEKQRG WPAGGKMFTQ PFRMKQQGSY STGSPVAKAR
     FSQPTSNMEP PKQILNVEKT FKSNVVETSR LNHTEKLNQL ENTFKSVIAQ IGPGGTISPE
     LKHKIRFVVS KFPEGLLISK LLREFEIIFK EQLSPKKLGF LNVIELVGAL SDILRVEFRE
     GEQDLLVFDA DMKPLPPAQS DKKIEVKAYV SSPPRNSLST AAVKETTWDC PPKNRKEPEQ
     KICKKPNLVV KPLQLQVEVN KSQRNLAMAN HDIPPDAVRD KKLCRLPLLD TSTLVGVFVE
     YIISPSQFYI RIYSRDSSEL LEDMMIEMRR CYSNQLVSDR YTLPEYFIQP GHLCCVRISE
     DKWWYRVIIH RVLGKQEVEV FYPDFGNIGT VQKSSLRFLK CCYTKLPAQA IPCSLAWVRP
     VEEHWTSKAI LQFQKLCGLK PLVGVVDEYV DGILNIFLCD TSSNEDVYFH HVLRTEGHAI
     VCRENVPSKG FRELNPLALY TKSSSGPEDV VLTELGYPSQ QHYFNEDREI SPQSKESELS
     TLDEIPTGMP CLESVTIGDD VWDENWLPLQ AKMGKGGDAA SHLFTSSLGG KKPYPSCKEM
     PQKDWCFSGP KDVWDDSWQP SGLMNGVKVE VQKQEGLGAQ EKNTGTTRIQ KPPPVESSLD
     LSTLPKLEEF YSSLIQSQQS AEGSQPEPSC IQTPAKPVQL STAALSASPM ALDSAEKHSG
     SVESSPESLK NDFSSSHAIT VFKDKSHGAM DQLSLILSPE HQISQKLYIP RSTATAALGA
     AARLATSRSL LHWYPSVKRM EA