ID   TDRD5_BOVIN             Reviewed;         975 AA.
AC   E1BPH3;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Tudor domain-containing protein 5;
GN   Name=TDRD5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
CC   -!- FUNCTION: Required during spermiogenesis to participate in the
CC       repression transposable elements and prevent their mobilization, which
CC       is essential for the germline integrity. Probably acts via the piRNA
CC       metabolic process, which mediates the repression of transposable
CC       elements during meiosis by forming complexes composed of piRNAs and
CC       Piwi proteins and govern the methylation and subsequent repression of
CC       transposons. Required for chromatoid body (CB) assembly (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to
CC       chromatoid body (CB) and pi-body (also called intermitochondrial
CC       cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA
CC       processing for spermatogenesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDRD5 family. {ECO:0000305}.
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DR   EMBL; AAFC03057220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03065883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03065884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03065886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03117511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03125112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E1BPH3; -.
DR   SMR; E1BPH3; -.
DR   STRING; 9913.ENSBTAP00000003118; -.
DR   eggNOG; KOG2039; Eukaryota.
DR   InParanoid; E1BPH3; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0033391; C:chromatoid body; ISS:UniProtKB.
DR   GO; GO:0071546; C:pi-body; ISS:UniProtKB.
DR   GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
DR   GO; GO:0030719; P:P granule organization; ISS:UniProtKB.
DR   GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR   CDD; cd09975; LOTUS_2_TDRD5; 1.
DR   CDD; cd04508; TUDOR; 1.
DR   Gene3D; 2.40.50.90; -; 1.
DR   Gene3D; 3.30.420.610; -; 3.
DR   InterPro; IPR041966; LOTUS-like.
DR   InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR037982; TDRD5_LOTUS_2.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF12872; OST-HTH; 3.
DR   Pfam; PF00567; TUDOR; 1.
DR   SMART; SM00333; TUDOR; 1.
DR   PROSITE; PS51644; HTH_OST; 3.
DR   PROSITE; PS50304; TUDOR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Differentiation; Phosphoprotein;
KW   Reference proteome; Repeat; Spermatogenesis.
FT   CHAIN           1..975
FT                   /note="Tudor domain-containing protein 5"
FT                   /id="PRO_0000408346"
FT   DOMAIN          7..80
FT                   /note="HTH OST-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          127..202
FT                   /note="HTH OST-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          299..373
FT                   /note="HTH OST-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          529..588
FT                   /note="Tudor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   REGION          820..843
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          864..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         891
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5VCS6"
SQ   SEQUENCE   975 AA;  109626 MW;  945AEE85A26F44D1 CRC64;
     MSEQERIQEC LRKEIRSLLI STKDGLTPQQ LEKEYLLMVG NHLPLRILGY RSTMELVLDM
     PDVVSVCPCG DGTVILKAIP DESTKGIANL VAKQKSNHKV RNSMQKGRAS VCSGPSSRRR
     VPYRGRVPPI LPAVVKSELK DLLALSPVLL SDFENAFANR FGRSFQYVQY GFLSMFEVLN
     AASDVISVEQ TRAGSLLTLK KSVSEEKQRG WPAAKGKIFT QPFRMKQQGS YPIGFPVAKA
     CFSQPTSNME PPKQILGMER NSRSNVMETS RLNHSEKLNQ LALTLQSWVV SHYGFNGSFS
     SAKKHKAMYT LRKFTENLMV CCLFNEYMLI FKEQLSPKKL GFLNVIELVG ALSDILHVEF
     REGEQDLLVF DADMKPLASV QPDKKTEAKA CVSSPPRNSL STAVIKETTW DCPSKNHKEP
     EQKIFKKPNL VVKPLQLQVE INKSQLSLAV ANHDIPPDAV RDKKLCRLPP LDTSTLVGVF
     VEYILSPSQF YIRIYSRDSS ELLEDMMIEM RRCYSNQLVS DRYAMPECFI QPGHLCCVRI
     SEDKWWYRVI IHRILGKQEV EVFYPDFGNI GTVQKSSLRF LKCCYTKLPA QAIPCSLAWV
     RPVEEHWTSR AVLQFQKLCG LKPLVGVVDE YVDGILNIFL CDTSSNEDVY FHHVLRTEGH
     AIVCRENVPS KGFRDLNPLA LYTKSSVTPE DIVLKELGYH SQQHYFNEDR EISPQSKESD
     LYTLDEIPTG MPYLESVTIG DDIWDENWLP LQAKMGKESD AASHLFTSSL GGKKPYPSCK
     EIPQKDWCFS TPKDIWDDSW QPSGLVNGMK VEVQIPEGLG AQEKHIDTTR IQKQSNVKSA
     SDSPALPKLE EFYISLIQSQ QSAEGSQFEP SNIQTPPKQI QLSSTPTLVN SGSVEGSPES
     LENEDFSSSS AITVFKDTSQ GAVDQLSLIL SPEHQISQKF YIPRSTATAA LGAAARLATS
     NSLLHWYPSV KKMET