TDRD5_RAT
ID TDRD5_RAT Reviewed; 995 AA.
AC B4F7C4;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Tudor domain-containing protein 5;
GN Name=Tdrd5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required during spermiogenesis to participate in the
CC repression transposable elements and prevent their mobilization, which
CC is essential for the germline integrity. Probably acts via the piRNA
CC metabolic process, which mediates the repression of transposable
CC elements during meiosis by forming complexes composed of piRNAs and
CC Piwi proteins and govern the methylation and subsequent repression of
CC transposons. Required for chromatoid body (CB) assembly (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to
CC chromatoid body (CB) and pi-body (also called intermitochondrial
CC cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA
CC processing for spermatogenesis. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TDRD5 family. {ECO:0000305}.
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DR EMBL; BC168218; AAI68218.1; -; mRNA.
DR RefSeq; NP_001128212.1; NM_001134740.1.
DR AlphaFoldDB; B4F7C4; -.
DR SMR; B4F7C4; -.
DR STRING; 10116.ENSRNOP00000005353; -.
DR PaxDb; B4F7C4; -.
DR PeptideAtlas; B4F7C4; -.
DR PRIDE; B4F7C4; -.
DR GeneID; 289129; -.
DR KEGG; rno:289129; -.
DR UCSC; RGD:1307078; rat.
DR CTD; 163589; -.
DR RGD; 1307078; Tdrd5.
DR eggNOG; KOG2039; Eukaryota.
DR HOGENOM; CLU_013593_0_0_1; -.
DR InParanoid; B4F7C4; -.
DR PhylomeDB; B4F7C4; -.
DR TreeFam; TF342664; -.
DR PRO; PR:B4F7C4; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0033391; C:chromatoid body; ISS:UniProtKB.
DR GO; GO:0043186; C:P granule; IBA:GO_Central.
DR GO; GO:0071546; C:pi-body; ISS:UniProtKB.
DR GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
DR GO; GO:0030719; P:P granule organization; ISS:UniProtKB.
DR GO; GO:0034587; P:piRNA metabolic process; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR CDD; cd09975; LOTUS_2_TDRD5; 1.
DR CDD; cd04508; TUDOR; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.420.610; -; 3.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR037982; TDRD5_LOTUS_2.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF12872; OST-HTH; 3.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00333; TUDOR; 1.
DR PROSITE; PS51644; HTH_OST; 3.
DR PROSITE; PS50304; TUDOR; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; Phosphoprotein;
KW Reference proteome; Repeat; Spermatogenesis.
FT CHAIN 1..995
FT /note="Tudor domain-containing protein 5"
FT /id="PRO_0000408348"
FT DOMAIN 7..80
FT /note="HTH OST-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 122..197
FT /note="HTH OST-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 291..365
FT /note="HTH OST-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 533..592
FT /note="Tudor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT REGION 747..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 946
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VCS6"
SQ SEQUENCE 995 AA; 111327 MW; D802E761DDD5E1F4 CRC64;
MSEQERIQDC LRKEIRSLLI STKDGLTPQQ LEKEYLLMVG NHLPLRILGY RSTMELVLDM
PDVVSVCPCG DGTVILKAIP DESTKGIASL VAKQRRSHKV RNSMQKGRSS VCSGRVPYRG
RVPPILPAVV KSELKDLLAL SPVLLSDFEK AFARRFGRSF QYMQYGFLSM FEVLSAASDV
ICVEQTRAGS LLTLKKSASE EKQREWPAGK IFTQPFRMKQ QGSYSTGFPV TKTRFSQPIS
NMEPPKQVLS MEKIPMFNTV EASRLSHTEK LNQLESTFKS VIAQIGPGGT VDPDLKHKIK
FVVSKFPQGL FISKLLGEFE LVFKEQLSPK QLGFLNVTEL VGALSDILRV EFSEEKQDLL
VFDADLRPLL PAGPLSSVRN SCLVQPDKRI EANAWASSPS RNSLSTVAVK KTTWDCPLKN
HKEAEQKAYK KPNLVVKPLQ LQVETNKSQL SLSMANHDIP PDAVRAKKLC RLPPLDTSTL
VGVFVEYIIS PSQFYVRIYS RDSSELLEDM MIEMRRCYSN QLVSDRYVMP EYFIQPGHLC
CVRISEDKWW YRVIIHRILG KKEVEVFYPD FGNIGTVQKS SLRFLKCCYT KLPAQAIPCS
LAWVRPAEEH WTSKAILHFQ KLCGLKPLVG VVDEYIDGIL NIFLCDTSSN EDVYFHHVLR
TEGHAIVCRE NAPSKGFRDF NPPALYTNSS AAPGDMVLTE LGHPAQQHYL NEDGEILQQP
QQDINDEKSI SHLKSVSEEL LKDSKLGPLK TRESCEEEPQ WSILKPKDPK EENEDEVPTG
MPCLESVTIG DDIWDENWLP LQAKMGKAGG PASHLFTSSL VGKKQYQTRG ETTRKDWCFS
TSKDIWDDSW QPLGLANDVK GRTHTPEGPI AQEKNIGTTR IRKQPDLQYP LDSSTLPKLE
EFYISLIKSQ QSAEGSQSEP ASIQTPLKPG QASSTAPSST PAAGDSPENH SGSAPDFSEA
LHSSKYSHGC LGSSCAVSHV QEPPALVPQC ERREA
