ID   TDRD5_XENTR             Reviewed;         963 AA.
AC   A0JM98;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Tudor domain-containing protein 5;
GN   Name=tdrd5;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required during spermiogenesis to participate in the
CC       repression transposable elements and prevent their mobilization, which
CC       is essential for the germline integrity. Probably acts via the piRNA
CC       metabolic process, which mediates the repression of transposable
CC       elements during meiosis by forming complexes composed of piRNAs and
CC       Piwi proteins and govern the methylation and subsequent repression of
CC       transposons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to
CC       chromatoid body (CB) and pi-body (also called intermitochondrial
CC       cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA
CC       processing for spermatogenesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDRD5 family. {ECO:0000305}.
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DR   EMBL; BC125795; AAI25796.1; -; mRNA.
DR   RefSeq; NP_001072763.1; NM_001079295.1.
DR   AlphaFoldDB; A0JM98; -.
DR   SMR; A0JM98; -.
DR   GeneID; 780220; -.
DR   KEGG; xtr:780220; -.
DR   CTD; 163589; -.
DR   Xenbase; XB-GENE-5884032; tdrd5.
DR   InParanoid; A0JM98; -.
DR   OrthoDB; 1115068at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0033391; C:chromatoid body; ISS:UniProtKB.
DR   GO; GO:0043186; C:P granule; IBA:GO_Central.
DR   GO; GO:0071546; C:pi-body; ISS:UniProtKB.
DR   GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
DR   GO; GO:0030719; P:P granule organization; ISS:UniProtKB.
DR   GO; GO:0034587; P:piRNA metabolic process; IBA:GO_Central.
DR   GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR   CDD; cd04508; TUDOR; 1.
DR   Gene3D; 2.40.50.90; -; 1.
DR   Gene3D; 3.30.420.610; -; 3.
DR   InterPro; IPR041966; LOTUS-like.
DR   InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF12872; OST-HTH; 3.
DR   Pfam; PF00567; TUDOR; 1.
DR   PROSITE; PS51644; HTH_OST; 3.
DR   PROSITE; PS50304; TUDOR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Reference proteome;
KW   Repeat; Spermatogenesis.
FT   CHAIN           1..963
FT                   /note="Tudor domain-containing protein 5"
FT                   /id="PRO_0000281124"
FT   DOMAIN          6..79
FT                   /note="HTH OST-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          122..197
FT                   /note="HTH OST-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          378..452
FT                   /note="HTH OST-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          589..648
FT                   /note="Tudor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   REGION          233..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          745..768
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   963 AA;  108205 MW;  97E4263AEBB74391 CRC64;
     MEQERIMQRI QKDVRALLIA SKNGLSIHEL EQDYRMMIGS HIPIRSLGYK STMELLLDMP
     SVVKIHTQLD GTVKLSAVVD ETTRRIADLV SCQKDRCTAR TRNRRRNIRP RCPVDLVRRG
     RVSPVLPATV KSDLRDLLSV SPLLLSELEK AFSSRFGRSF QYTRYGFYSM LEVLRSITDI
     VEVKQTRAGS LLVLRNSETG RISASLCVKQ SQLAIDPKKT SCVLEQCLKE PRTPEKKTSE
     TVTYLKVSPP EPQKLSSKES PSVTRSTSPL INSSNKEQRL KLNVLLDESL KSNENKAPPV
     TNFTSAVPSH NSVLSNSLVG NSVSSETLFT KMSRPTSHVE ADHSAASEPD ASVLEWLEKK
     LEKELKLCLA RKGAGGSVSD ALRMDIQHVV NQHSDGLKIS QLPTVFKSFT GKDLPFKELG
     FMSVMELVGS LGDILCVEST VDGKDWKLFD AKKKDLVDEF SAGLPSTSSI LSSWNSSQQT
     TTPVKPVGTI FSKVDEKLWW GPLELKLCST EQIDIPPDAV RNQKLHCLPS MKRGFMIGVY
     VENIESPSQF YVRCCGKDTS EKLEDMMIEM RHCYSNECVS ERYIVTDNCI SVGQIYALRV
     PGDVWWYRVI VHDIKNSELL DVFYPDFGNV ATVKKSWLRF LKNCYMKIPA QAVPSSLPYV
     TSTEDQWSAQ AIKKFQQLCS CIPLVGMVLQ YVQDILHIFL CDTSSEEDLY LHQLLISQGL
     AKMEPEHACK KISKKRNPFM QYLTPSQEQP QEESSQLSVP SESSQSEIPC AKEVKDEDDL
     GMPYLEAFPS GSDVWDENWA FSDGACDYDT APTIPKVDTQ KQQENKVSQE TQPFKFCIDS
     ADASVVHHPL EEFYISLIKS RKSQESTDIQ QSPPTEEQHV AEISHRSATE QLQGGSSSSM
     LCEKKLYYEK EDLPYCQQSK CSFSPLLGFQ RLQIPRSATP VALGPAARLA TAGRLLYWAS
     EPR