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TDRD6_HUMAN
ID   TDRD6_HUMAN             Reviewed;        2096 AA.
AC   O60522; B3KWU2; F5H5M3; Q5HYB1; Q5VTS4; Q6ZMX5;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 173.
DE   RecName: Full=Tudor domain-containing protein 6;
DE   AltName: Full=Antigen NY-CO-45;
DE   AltName: Full=Cancer/testis antigen 41.2;
DE            Short=CT41.2;
GN   Name=TDRD6 {ECO:0000312|HGNC:HGNC:21339};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1161 (ISOFORM 1), NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 887-2066 (ISOFORM 2), AND VARIANT GLU-1014.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1073-2096 (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1271-2096 (ISOFORM 1).
RC   TISSUE=Colon tumor;
RX   PubMed=9610721;
RX   DOI=10.1002/(sici)1097-0215(19980529)76:5<652::aid-ijc7>3.0.co;2-p;
RA   Scanlan M.J., Chen Y.-T., Williamson B., Gure A.O., Stockert E.,
RA   Gordan J.D., Tuereci O., Sahin U., Pfreundschuh M., Old L.J.;
RT   "Characterization of human colon cancer antigens recognized by autologous
RT   antibodies.";
RL   Int. J. Cancer 76:652-658(1998).
CC   -!- FUNCTION: Tudor domain-containing protein involved in germ cell
CC       development, more specifically the formation of chromatoid body (during
CC       spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon
CC       fertilization), and for proper miRNA expression and spliceosome
CC       maturation (By similarity). Essential for RNA-dependent helicase UPF1
CC       localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4
CC       interactions which are required for mRNA degradation, using the
CC       extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway.
CC       Involved in spliceosome maturation and mRNA splicing in prophase I
CC       spermatocytes through interaction with arginine N-methyltransferase
CC       PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear
CC       ribonucleoprotein-associated protein) (By similarity).
CC       {ECO:0000250|UniProtKB:F1R237, ECO:0000250|UniProtKB:P61407}.
CC   -!- SUBUNIT: Found in a mRNP complex (i.e. messenger ribonucleoproteins
CC       which correspond to mRNA with bound proteins), at least composed of
CC       TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex, at least composed of
CC       PIWIL1, PIWIL2, DDX4 and TDRD6. Interacts with Tex19.1 and probably
CC       Tex19.2. Interacts with PRMT5. Interacts with SNRPB (when methylated);
CC       to trigger spliceosome formation. {ECO:0000250|UniProtKB:P61407}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61407}.
CC       Note=Present in chromatoid body (CB) of spermatids, also named
CC       processing bodies (P-bodies) in somatic cells. Detected in the
CC       multilobular cytoplasmic CBs (also called intermitochondrial cementin)
CC       in pachytene spermatocytes and as a single perinuclear CB in haploid
CC       round spermatids. Colocalizes in CB with DDX4, PIWIL1, PIWIL2, TDRD1
CC       and TDRD7. {ECO:0000250|UniProtKB:P61407}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O60522-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O60522-2; Sequence=VSP_044801;
CC   -!- DOMAIN: The tudor domains recognize and bind to proteins with
CC       dimethylated arginine residues. {ECO:0000250|UniProtKB:P61407}.
CC   -!- PTM: Undergoes proteolytic cleavage near the C-terminal by an unknown
CC       protease during the transition from meiosis I to meiosis II in primary
CC       spermatocytes. {ECO:0000250|UniProtKB:P61407}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC18034.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAI45997.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL591242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK125838; BAG54254.1; -; mRNA.
DR   EMBL; AK131455; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BX648686; CAI45997.1; ALT_INIT; mRNA.
DR   EMBL; AF039442; AAC18034.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS34470.1; -. [O60522-1]
DR   CCDS; CCDS55017.1; -. [O60522-2]
DR   RefSeq; NP_001010870.1; NM_001010870.2. [O60522-1]
DR   RefSeq; NP_001161831.1; NM_001168359.1. [O60522-2]
DR   AlphaFoldDB; O60522; -.
DR   SMR; O60522; -.
DR   BioGRID; 128720; 4.
DR   IntAct; O60522; 2.
DR   STRING; 9606.ENSP00000346065; -.
DR   iPTMnet; O60522; -.
DR   PhosphoSitePlus; O60522; -.
DR   SwissPalm; O60522; -.
DR   BioMuta; TDRD6; -.
DR   EPD; O60522; -.
DR   jPOST; O60522; -.
DR   MassIVE; O60522; -.
DR   MaxQB; O60522; -.
DR   PaxDb; O60522; -.
DR   PeptideAtlas; O60522; -.
DR   PRIDE; O60522; -.
DR   ProteomicsDB; 26920; -.
DR   ProteomicsDB; 49457; -. [O60522-1]
DR   Antibodypedia; 48657; 7 antibodies from 6 providers.
DR   DNASU; 221400; -.
DR   Ensembl; ENST00000316081.11; ENSP00000346065.5; ENSG00000180113.16. [O60522-1]
DR   Ensembl; ENST00000544460.5; ENSP00000443299.1; ENSG00000180113.16. [O60522-2]
DR   GeneID; 221400; -.
DR   KEGG; hsa:221400; -.
DR   MANE-Select; ENST00000316081.11; ENSP00000346065.5; NM_001010870.3; NP_001010870.1.
DR   UCSC; uc003oyj.4; human. [O60522-1]
DR   CTD; 221400; -.
DR   DisGeNET; 221400; -.
DR   GeneCards; TDRD6; -.
DR   HGNC; HGNC:21339; TDRD6.
DR   HPA; ENSG00000180113; Tissue enhanced (testis).
DR   MIM; 611200; gene.
DR   neXtProt; NX_O60522; -.
DR   OpenTargets; ENSG00000180113; -.
DR   PharmGKB; PA134945900; -.
DR   VEuPathDB; HostDB:ENSG00000180113; -.
DR   eggNOG; KOG2039; Eukaryota.
DR   GeneTree; ENSGT00940000159049; -.
DR   HOGENOM; CLU_001126_1_0_1; -.
DR   InParanoid; O60522; -.
DR   OMA; VDYGQTK; -.
DR   OrthoDB; 496838at2759; -.
DR   PhylomeDB; O60522; -.
DR   PathwayCommons; O60522; -.
DR   Reactome; R-HSA-5601884; PIWI-interacting RNA (piRNA) biogenesis.
DR   SignaLink; O60522; -.
DR   BioGRID-ORCS; 221400; 9 hits in 1065 CRISPR screens.
DR   ChiTaRS; TDRD6; human.
DR   GenomeRNAi; 221400; -.
DR   Pharos; O60522; Tdark.
DR   PRO; PR:O60522; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; O60522; protein.
DR   Bgee; ENSG00000180113; Expressed in secondary oocyte and 131 other tissues.
DR   ExpressionAtlas; O60522; baseline and differential.
DR   Genevisible; O60522; HS.
DR   GO; GO:0033391; C:chromatoid body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043186; C:P granule; IBA:GO_Central.
DR   GO; GO:0030719; P:P granule organization; IBA:GO_Central.
DR   GO; GO:0034587; P:piRNA metabolic process; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   CDD; cd04508; TUDOR; 6.
DR   Gene3D; 2.40.50.90; -; 7.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF00567; TUDOR; 7.
DR   SMART; SM00333; TUDOR; 8.
DR   PROSITE; PS50304; TUDOR; 6.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW   Phosphoprotein; Reference proteome; Repeat; Spermatogenesis.
FT   CHAIN           1..2096
FT                   /note="Tudor domain-containing protein 6"
FT                   /id="PRO_0000183167"
FT   DOMAIN          65..120
FT                   /note="Tudor 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          310..369
FT                   /note="Tudor 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          536..593
FT                   /note="Tudor 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          816..875
FT                   /note="Tudor 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          1033..1088
FT                   /note="Tudor 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          1352..1411
FT                   /note="Tudor 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          1567..1626
FT                   /note="Tudor 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          2026..2084
FT                   /note="Tudor 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   REGION          287..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         293
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P61407"
FT   MOD_RES         1722
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P61407"
FT   MOD_RES         2062
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P61407"
FT   VAR_SEQ         2058..2087
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044801"
FT   VARIANT         192
FT                   /note="R -> Q (in dbSNP:rs7750596)"
FT                   /id="VAR_029050"
FT   VARIANT         398
FT                   /note="T -> A (in dbSNP:rs3799277)"
FT                   /id="VAR_029051"
FT   VARIANT         795
FT                   /note="I -> M (in dbSNP:rs9463234)"
FT                   /id="VAR_052423"
FT   VARIANT         1014
FT                   /note="Q -> E (in dbSNP:rs9381472)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_029052"
FT   CONFLICT        1273
FT                   /note="E -> K (in Ref. 4; AAC18034)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1455
FT                   /note="Q -> R (in Ref. 3; CAI45997)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1955
FT                   /note="M -> V (in Ref. 3; CAI45997)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2016
FT                   /note="A -> D (in Ref. 4; AAC18034)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2096 AA;  236517 MW;  19FED65D6FE68E44 CRC64;
     MCSTPGMPAP GASLALRVSF VDVHPDVIPV QLWGLVGERR GEYLRLSREI QEAAATRGQW
     ALGSASASPG ELCLVQVGLL WHRCRVVSRQ AQESRVFLLD EGRTITAGAG SLAPGRREFF
     NLPSEVLGCV LAGLVPAGCG AGSGEPPQHW PADAVDFLSN LQGKEVHGCV LDVLLLHRLV
     LLEVPDVFQQ MRELGLARRV PDSLFRSLLE RYLTAATASV GSGVPVLSRV PLKQKQPGLD
     YFYPQLQLGV TEAVVITQVC HPHRIHCQLR SVSQEIHRLS ESMAQVYRGS TGTGDENSTS
     ATWEEREESP DKPGSPCASC GLDGHWYRAL LLETFRPQRC AQVLHVDYGR KELVSCSSLR
     YLLPEYFRMP VVTYPCALYG LWDGGRGWSR SQVGDLKTLI LGKAVNAKIE FYCSFEHVYY
     VSLYGEDGIN LNRVFGVQSC CLADRVLQSQ ATEEEEPETS QSQSPAEEVD EEISLPALRS
     IRLKMNAFYD AQVEFVKNPS EFWIRLRKHN VTFSKLMRRM CGFYSSASKL DGVVLKPEPD
     DLCCVKWKEN GYYRAIVTKL DDKSVDVFLV DRGNSENVDW YDVRMLLPQF RQLPILAVKC
     TLADIWPLGK TWSQEAVSFF KKTVLHKELV IHILDKQDHQ YVIEILDESR TGEENISKVI
     AQAGYAKYQE FETKENILVN AHSPGHVSNH FTTESNKIPF AKTGEGEQKA KRENKTTSVS
     KALSDTTVVT NGSTELVVQE KVKRASVYFP LMQNCLEIKP GSSSKGELEV GSTVEVRVSY
     VENPGYFWCQ LTRNIQGLKT LMSDIQYYCK NTAAPHQRNT LACLAKRTVN RQWSRALISG
     IQSVEHVNVT FVDYGDREMV SVKNIYSISE EFLKVKAQAF RCSLYNLIQP VGQNPFVWDV
     KAIQAFNEFI DNAWQKNLEL KCTIFALASI NEELFNIVDL LTPFQSACHF LVEKRLARPV
     KLQKPLESSV QLHSYFYSTH DMKIGSEELV YITHIDDPWT FYCQLARNAN ILEQLSCSIT
     QLSKVLLNLK TSPLNPGTLC LAKYTDGNWY RGIVIEKEPK KVFFVDFGNI YVVTSDDLLP
     IPSDAYDVLL LPMQAVRCSL SDIPDHIPEE VVVWFQETIL DKSLKALVVA KDPDGTLIIE
     LYGDNIQISA SINKKLGLLS YKDRIRKKES EVLCSTTETL EEKNENMKLP CTEYLSKSVG
     YKLPNKEILE ESYKPQINSS YKELKLLQSL TKTNLVTQYQ DSVGNKNSQV FPLTTEKKEE
     ISAETPLKTA RVEATLSERK IGDSCDKDLP LKFCEFPQKT IMPGFKTTVY VSHINDLSDF
     YVQLIEDEAE ISHLSERLNS VKTRPEYYVG PPLQRGDMIC AVFPEDNLWY RAVIKEQQPN
     DLLSVQFIDY GNVSVVHTNK IGRLDLVNAI LPGLCIHCSL QGFEVPDNKN SKKMMHYFSQ
     RTSEAAIRCE FVKFQDRWEV ILADEHGIIA DDMISRYALS EKSQVELSTQ VIKSASSKSV
     NKSDIDTSVF LNWYNPEKKM IRAYATVIDG PEYFWCQFAD TEKLQCLEVE VQTAGEQVAD
     RRNCIPCPYI GDPCIVRYRE DGHYYRALIT NICEDYLVSV RLVDFGNIED CVDPKALWAI
     PSELLSVPMQ AFPCCLSGFN ISEGLCSQEG NDYFYEIITE DVLEITILEI RRDVCDIPLA
     IVDLKSKGKS INEKMEKYSK TGIKSALPYE NIDSEIKQTL GSYNLDVGLK KLSNKAVQNK
     IYMEQQTDEL AEITEKDVNI IGTKPSNFRD PKTDNICEGF ENPCKDKIDT EELEGELECH
     LVDKAEFDDK YLITGFNTLL PHANETKEIL ELNSLEVPLS PDDESKEFLE LESIELQNSL
     VVDEEKGELS PVPPNVPLSQ ECVTKGAMEL FTLQLPLSCE AEKQPELELP TAQLPLDDKM
     DPLSLGVSQK AQESMCTEDM RKSSCVESFD DQRRMSLHLH GADCDPKTQN EMNICEEEFV
     EYKNRDAISA LMPLFSEEES SDGSKHNNGL PDHISAQLQN TYTLKAFTVG SKCVVWSSLR
     NTWSKCEILE TAEEGTRVLN LSNGMEEIVN PENVWNGIPK LDKSPPEKRG LEVMEI
 
 
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