TDRD7_CHICK
ID TDRD7_CHICK Reviewed; 1071 AA.
AC E1C3S7;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Tudor domain-containing protein 7;
GN Name=TDRD7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=21436445; DOI=10.1126/science.1195970;
RA Lachke S.A., Alkuraya F.S., Kneeland S.C., Ohn T., Aboukhalil A.,
RA Howell G.R., Saadi I., Cavallesco R., Yue Y., Tsai A.C., Nair K.S.,
RA Cosma M.I., Smith R.S., Hodges E., Alfadhli S.M., Al-Hajeri A.,
RA Shamseldin H.E., Behbehani A., Hannon G.J., Bulyk M.L., Drack A.V.,
RA Anderson P.J., John S.W., Maas R.L.;
RT "Mutations in the RNA granule component TDRD7 cause cataract and
RT glaucoma.";
RL Science 331:1571-1576(2011).
CC -!- FUNCTION: Component of specific cytoplasmic RNA granules involved in
CC post-transcriptional regulation of specific genes: probably acts by
CC binding to specific mRNAs and regulating their translation. Required
CC for lens transparency during lens development, by regulating
CC translation of specific genes in the developing lens. Also required
CC during spermatogenesis. {ECO:0000269|PubMed:21436445}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to
CC cytoplasmic RNA granules. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the developing lens.
CC {ECO:0000269|PubMed:21436445}.
CC -!- SIMILARITY: Belongs to the TDRD7 family. {ECO:0000305}.
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DR EMBL; AADN02060121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AADN02060133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E1C3S7; -.
DR SMR; E1C3S7; -.
DR PaxDb; E1C3S7; -.
DR VEuPathDB; HostDB:geneid_430492; -.
DR InParanoid; E1C3S7; -.
DR PhylomeDB; E1C3S7; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035770; C:ribonucleoprotein granule; ISS:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR GO; GO:0070306; P:lens fiber cell differentiation; IMP:UniProtKB.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; IMP:UniProtKB.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR CDD; cd09974; LOTUS_3_TDRD7; 1.
DR CDD; cd04508; TUDOR; 2.
DR Gene3D; 2.40.50.90; -; 3.
DR Gene3D; 3.30.420.610; -; 3.
DR InterPro; IPR041966; LOTUS-like.
DR InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR037978; TDRD7_LOTUS_3.
DR InterPro; IPR002999; Tudor.
DR Pfam; PF12872; OST-HTH; 1.
DR Pfam; PF00567; TUDOR; 3.
DR SMART; SM00333; TUDOR; 3.
DR PROSITE; PS51644; HTH_OST; 3.
DR PROSITE; PS50304; TUDOR; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Differentiation; Reference proteome; Repeat; RNA-binding;
KW Spermatogenesis.
FT CHAIN 1..1071
FT /note="Tudor domain-containing protein 7"
FT /id="PRO_0000409517"
FT DOMAIN 3..76
FT /note="HTH OST-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 221..289
FT /note="HTH OST-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 330..399
FT /note="HTH OST-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT DOMAIN 500..557
FT /note="Tudor 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT DOMAIN 689..746
FT /note="Tudor 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT REGION 295..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1071 AA; 121561 MW; 34F25C0F8292717B CRC64;
MQEPDLVAKA LRSVLHSSKH GIPLSELQDE YRSLTGEWIP FRHLGYATLE AYVASIPEVV
RIERNQTGEV TCHAVACPET IYVRVWAVAH KRTSPIFLLF CCRQNIEKTL QMIRVLDICA
IFKDPRWSSE VSFVVSVSVC LRRDQLSHHG FKRSCTFTCP EGLPLIQMVS FPIKSILSEK
GLIPAYEKNH SNSEFYFSLT DNLNASGVET HTVASGRSVP NISEIQNRIK EILSKYRNGV
WLSKIAQVYE ETYREELSTT VLRQLEHWPH VCTVEKVRTG DQTYRILYPS KRIPPAVKSN
TEQDQASQNV TSSKAGPVLK TSREAESASC SSDFKQNVVN ILVKYPCGLW ADALPKLYQD
AYQRKFPEGI LNNLQLLSDV CVVDYVSNVP QKAILYVKTQ SCTDENLNVT EKVQIPDGAK
ATAEQQHEES KEQYPESISS VPPLVIPSEG PVSVLVIDVN NPNELIIRYV GKDYSGAQEQ
MEDKMKAYYS KNSTASQITF PSVGQLVAVH TEEEAWLRAQ IISVEDKRLK LSCFCTYFGC
ITFRMCKPKE NTHCCMKQCT SHKCKLTGLE VFSDDPLLLK AVELQAYHKI CAVEILERSD
IPVFVLYDTS GEDDININAT CLKALYDKSF ELNLQVDTLY TNVRVTSILS DGNMYCQLPS
EGLSKLSEVL QKIEYYLLHQ ETSEFNVSQP YCGKICLFLC KGKWTRVEIT IIHSRRALGV
RFIDTGRVAY VKVTDLREIP SQFLREVIKI PPQAIKCCLA DLPPDTGMWT PEAVLWLRDN
VMDYAEFSMQ VSVMEKRCVL KFWKAFIPIS YLLADRSINR RINAVLWKHQ KDVFLSVTSQ
GLAPPKHLNQ GRLEKSDSLE PAVESRGVES ATDVPPPLPL SEVGGFMDVY VSVACHPGHF
IVQPWKEIHN LEALMEEMIL YYSMAEERPV NIGTNKLYAA KIENRWYRVI VKGILRKGFL
SVYVLDYGKH EVISIDKVQP LLDKFRKLPF QAIKAELAGV KSQQWSEEAS IIFRNRVEKK
PLVAQIQAIN ESTNSWDRKV VTYLVDTSIP DTDVWIHDFV CQSLAELSEA D
