ID   TDRD7_XENLA             Reviewed;        1079 AA.
AC   Q6NU04;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Tudor domain-containing protein 7;
GN   Name=tdrd7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of specific cytoplasmic RNA granules involved in
CC       post-transcriptional regulation of specific genes: probably acts by
CC       binding to specific mRNAs and regulating their translation. Probably
CC       required during spermatogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Localizes to cytoplasmic RNA
CC       granules. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDRD7 family. {ECO:0000305}.
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DR   EMBL; BC068798; AAH68798.1; -; mRNA.
DR   RefSeq; NP_001084569.2; NM_001091100.1.
DR   AlphaFoldDB; Q6NU04; -.
DR   SMR; Q6NU04; -.
DR   DNASU; 414521; -.
DR   GeneID; 414521; -.
DR   KEGG; xla:414521; -.
DR   CTD; 414521; -.
DR   Xenbase; XB-GENE-944688; tdrd7.L.
DR   OrthoDB; 1276848at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 414521; Expressed in testis and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035770; C:ribonucleoprotein granule; ISS:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0070306; P:lens fiber cell differentiation; ISS:UniProtKB.
DR   GO; GO:0002089; P:lens morphogenesis in camera-type eye; ISS:UniProtKB.
DR   GO; GO:0010608; P:post-transcriptional regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   CDD; cd09974; LOTUS_3_TDRD7; 1.
DR   CDD; cd04508; TUDOR; 3.
DR   Gene3D; 2.40.50.90; -; 3.
DR   Gene3D; 3.30.420.610; -; 3.
DR   InterPro; IPR041966; LOTUS-like.
DR   InterPro; IPR025605; OST-HTH/LOTUS_dom.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR037978; TDRD7_LOTUS_3.
DR   InterPro; IPR002999; Tudor.
DR   Pfam; PF12872; OST-HTH; 2.
DR   Pfam; PF00567; TUDOR; 3.
DR   SMART; SM00333; TUDOR; 3.
DR   PROSITE; PS51644; HTH_OST; 3.
DR   PROSITE; PS50304; TUDOR; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; Reference proteome; Repeat; RNA-binding;
KW   Spermatogenesis.
FT   CHAIN           1..1079
FT                   /note="Tudor domain-containing protein 7"
FT                   /id="PRO_0000409520"
FT   DOMAIN          1..69
FT                   /note="HTH OST-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          218..288
FT                   /note="HTH OST-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          330..398
FT                   /note="HTH OST-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00975"
FT   DOMAIN          494..551
FT                   /note="Tudor 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   DOMAIN          684..741
FT                   /note="Tudor 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00211"
FT   REGION          109..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1079 AA;  120959 MW;  D6FB4595E4CBB276 CRC64;
     MLRAVLQANK NGVPLHKLQA EYKSVTGEPI PFKDMGFPAL DAYLKSIPSV VRIEVSRVGE
     VTCYAVACKE TARIAELVAH QRSSKKKGGH QVNCQMRLKS TAPVSHFGKP KITLRQPGFT
     PPQEMMIRKP VPTPPWGKGN YFGPRTFEYS PQPIPQLFGV APMQRHLPNM NRPERKVTLP
     PRFQREVKSP LLPTPITDSN ANHTQSYKRV VIGSGQSDLP VIQNNLKELL NKHSNGLWLS
     KLPQLYKETY KQDLGGEVLK QVPSWTHICT VQKLVSSGHT EIVIYATTRK QQPSTKNIQN
     RSNDQAKPNV PVVLSTPSSP PPLQISGSIP KDELKEKIST ILTKYSNGLW YHALPKVFED
     MFKQKLPIEA FNLDSLTDIC TVDLISEEPF KAILYGKSAE RAVQNSNPSV NNNIPQKLHD
     REPPLCSEEP DMTMAPPPLV IPSEASPSVL VVELNSTNDV VIRYIGRDYS AAQERMEDEL
     KDFCSKSSTA QVRPLRVGQL VAAKAEEDAW LRAQISAIED KKIKVCYVDY GFSETVDITK
     VCKLGKPFYT LPFQATKCRL AGLEAFCDDS VIIKALEAKA CGKILAVEIL HKSEKPLVVL
     YDTSGDDDIN INAACLKELY DRSLSLQLKA NLSFSNVTVT NVCSDGTLFC QVPSKGLAKL
     YETLQKVDGE FQFQQVTSHL YVSLPFCGKI CLYHYKGKWA RVEITNVHSS RALDVHFLDS
     GTIASVKVSE LKEIPPPLLR DLISIPPQAL KCCLADLPLN IGMWTPDAVL WLRNTVLNCP
     ECSIKVVKID EAMNMVHIYL FTSNNFPDLE RSINRRITNE ELLKQKQKDV FLNMSVSSLE
     KGRGGGGAPA SQLFPSGPCI SPTSVAKKPD MQQSSPVPSF NMPPALPLPR PGEHMDVFVS
     VACHPGHFVC QPWQELHKLE LVMDEMRLHY STTEEKPIAL EKNKLYAAKI ENNWYRVLVK
     GILTNGLVSV YELDHGRHEL VSCRKVQPLI EKFMHLPFQA ITSQLAGINC EQWSEETSIV
     FRNHVEKKPL VALVQTIHES THPWERRVVA YIVDTTLPDT DIWIHELMTE YLAQFSKPE