TDRP_HUMAN
ID TDRP_HUMAN Reviewed; 185 AA.
AC Q86YL5; B6VF03; B9EG53;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Testis development-related protein;
DE AltName: Full=Protein INM01;
GN Name=TDRP; Synonyms=C8orf42;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND POLYMORPHISM OF POLY-ALA
RP REGION.
RX PubMed=15163304; DOI=10.1677/erc.0.0110295;
RA Wang X.-C., Xu S.-Y., Wu X.-Y., Song H.-D., Mao Y.-F., Fan H.-Y., Yu F.,
RA Mou B., Gu Y.-Y., Xu L.-Q., Zhou X.-O., Chen Z., Chen J.-L., Hu R.-M.;
RT "Gene expression profiling in human insulinoma tissue: genes involved in
RT the insulin secretion pathway and cloning of novel full-length cDNAs.";
RL Endocr. Relat. Cancer 11:295-303(2004).
RN [2]
RP SEQUENCE REVISION.
RA Wang X.-C., Hu R.-M., Song H.-D., Xu S.Y., Wu X.-Y., Fan H.-Y., Chen Z.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=20170638; DOI=10.1016/j.bbrc.2010.02.061;
RA Wang X., Jiang H., Zhou W., Zhang Z., Yang Z., Lu Y., Lu B., Wang X.,
RA Ding Q., Hu R.;
RT "Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells
RT of testis and its relationship with spermatogenesis.";
RL Biochem. Biophys. Res. Commun. 394:29-35(2010).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND POLYMORPHISM OF
RP POLY-ALA REGION.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=27069551;
RA Mao S., Wu F., Cao X., He M., Liu N., Wu H., Yang Z., Ding Q., Wang X.;
RT "TDRP deficiency contributes to low sperm motility and is a potential risk
RT factor for male infertility.";
RL Am. J. Transl. Res. 8:177-187(2016).
CC -!- FUNCTION: Contributes to normal sperm motility, but not essential for
CC male fertility. {ECO:0000250|UniProtKB:Q8C5P7}.
CC -!- SUBUNIT: Interacts with PRM2. {ECO:0000250|UniProtKB:Q8C5P7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20170638,
CC ECO:0000269|PubMed:27069551}. Cytoplasm {ECO:0000269|PubMed:20170638,
CC ECO:0000269|PubMed:27069551}. Note=Mainly nuclear. Also detected in
CC cytoplasm near the midpiece of the flagellum.
CC {ECO:0000269|PubMed:27069551}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=TDRP1;
CC IsoId=Q86YL5-1; Sequence=Displayed;
CC Name=2; Synonyms=TDRP2;
CC IsoId=Q86YL5-2; Sequence=VSP_045212;
CC -!- TISSUE SPECIFICITY: Expressed in spermatogenic cells, especially in
CC spermatocytes (at protein level). {ECO:0000269|PubMed:20170638}.
CC -!- POLYMORPHISM: The poly-Ala region seems to be polymorphic and the
CC number of Ala varies between 4 and 6. {ECO:0000269|PubMed:15163304}.
CC -!- SIMILARITY: Belongs to the TDRP family. {ECO:0000305}.
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DR EMBL; AY194292; AAO23974.2; -; mRNA.
DR EMBL; FJ381685; ACJ10204.1; -; mRNA.
DR EMBL; AC083964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136248; AAI36249.1; -; mRNA.
DR EMBL; BC136249; AAI36250.1; -; mRNA.
DR CCDS; CCDS47759.1; -. [Q86YL5-1]
DR CCDS; CCDS59090.1; -. [Q86YL5-2]
DR RefSeq; NP_001243042.1; NM_001256113.1. [Q86YL5-2]
DR RefSeq; NP_778250.2; NM_175075.4. [Q86YL5-1]
DR RefSeq; XP_006716295.1; XM_006716232.3.
DR AlphaFoldDB; Q86YL5; -.
DR BioGRID; 127614; 5.
DR STRING; 9606.ENSP00000430325; -.
DR iPTMnet; Q86YL5; -.
DR PhosphoSitePlus; Q86YL5; -.
DR BioMuta; TDRP; -.
DR EPD; Q86YL5; -.
DR jPOST; Q86YL5; -.
DR MassIVE; Q86YL5; -.
DR MaxQB; Q86YL5; -.
DR PaxDb; Q86YL5; -.
DR PeptideAtlas; Q86YL5; -.
DR PRIDE; Q86YL5; -.
DR ProteomicsDB; 6251; -.
DR ProteomicsDB; 70428; -. [Q86YL5-1]
DR Antibodypedia; 2036; 50 antibodies from 13 providers.
DR DNASU; 157695; -.
DR Ensembl; ENST00000324079.11; ENSP00000315111.6; ENSG00000180190.13. [Q86YL5-1]
DR Ensembl; ENST00000523656.5; ENSP00000430325.1; ENSG00000180190.13. [Q86YL5-2]
DR GeneID; 157695; -.
DR KEGG; hsa:157695; -.
DR MANE-Select; ENST00000324079.11; ENSP00000315111.6; NM_001384899.1; NP_001371828.1.
DR UCSC; uc011kwg.3; human. [Q86YL5-1]
DR CTD; 157695; -.
DR DisGeNET; 157695; -.
DR GeneCards; TDRP; -.
DR HGNC; HGNC:26951; TDRP.
DR HPA; ENSG00000180190; Low tissue specificity.
DR MIM; 619049; gene.
DR neXtProt; NX_Q86YL5; -.
DR OpenTargets; ENSG00000180190; -.
DR PharmGKB; PA142672361; -.
DR VEuPathDB; HostDB:ENSG00000180190; -.
DR eggNOG; ENOG502RYNW; Eukaryota.
DR GeneTree; ENSGT00390000017888; -.
DR HOGENOM; CLU_094260_0_0_1; -.
DR InParanoid; Q86YL5; -.
DR OMA; GHCFWDS; -.
DR OrthoDB; 1500031at2759; -.
DR PhylomeDB; Q86YL5; -.
DR TreeFam; TF335521; -.
DR PathwayCommons; Q86YL5; -.
DR BioGRID-ORCS; 157695; 13 hits in 1039 CRISPR screens.
DR ChiTaRS; TDRP; human.
DR GenomeRNAi; 157695; -.
DR Pharos; Q86YL5; Tbio.
DR PRO; PR:Q86YL5; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q86YL5; protein.
DR Bgee; ENSG00000180190; Expressed in secondary oocyte and 165 other tissues.
DR Genevisible; Q86YL5; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IDA:MGI.
DR InterPro; IPR031399; TDRP.
DR Pfam; PF15683; TDRP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..185
FT /note="Testis development-related protein"
FT /id="PRO_0000308219"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 167..185
FT /note="VSIRRQSKGHLTDSPEEAE -> IKEVWINFSQLIISFRKHCLAHYRELRLC
FT IKY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:20170638"
FT /id="VSP_045212"
SQ SEQUENCE 185 AA; 20403 MW; BEE358C6A468DD42 CRC64;
MWKLGRGRVL LDEPPEEEDG LRGGPPPAAA AAAQAQVQGA SFRGWKEVTS LFNKDDEQHL
LERCKSPKSK GTNLRLKEEL KAEKKSGFWD NLVLKQNIQS KKPDEIEGWE PPKLALEDIS
ADPEDTVGGH PSWSGWEDDA KGSTKYTSLA SSANSSRWSL RAAGRLVSIR RQSKGHLTDS
PEEAE
