TDRP_MOUSE
ID TDRP_MOUSE Reviewed; 182 AA.
AC Q8C5P7; Q3TQC8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Testis development-related protein;
GN Name=Tdrp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Blastocyst, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION, INTERACTION WITH PRM2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=27069551;
RA Mao S., Wu F., Cao X., He M., Liu N., Wu H., Yang Z., Ding Q., Wang X.;
RT "TDRP deficiency contributes to low sperm motility and is a potential risk
RT factor for male infertility.";
RL Am. J. Transl. Res. 8:177-187(2016).
CC -!- FUNCTION: Contributes to normal sperm motility, but not essential for
CC male fertility. {ECO:0000269|PubMed:27069551}.
CC -!- SUBUNIT: Interacts with PRM2. {ECO:0000269|PubMed:27069551}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27069551}. Cytoplasm
CC {ECO:0000269|PubMed:27069551}. Note=Mainly nuclear. Also detected in
CC cytoplasm near the midpiece of the flagellum.
CC {ECO:0000269|PubMed:27069551}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C5P7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C5P7-2; Sequence=VSP_028924;
CC -!- TISSUE SPECIFICITY: Strongly expressed in testis. Also detected at
CC lower levels in epididymis, bone marrow and kidney.
CC {ECO:0000269|PubMed:27069551}.
CC -!- DISRUPTION PHENOTYPE: Viable with no gross morphological defects.
CC Morphology of testis tissue and mature epididymal sperm is normal.
CC Sperm counts are also normal. Sperm motility is reduced, however this
CC has no significant effect on male fertility.
CC {ECO:0000269|PubMed:27069551}.
CC -!- SIMILARITY: Belongs to the TDRP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK077810; BAC37021.1; -; mRNA.
DR EMBL; AK163687; BAE37456.1; -; mRNA.
DR EMBL; AK166875; BAE39086.1; -; mRNA.
DR EMBL; AK166972; BAE39155.1; -; mRNA.
DR EMBL; BC099613; AAH99613.1; -; mRNA.
DR EMBL; BC132465; AAI32466.1; -; mRNA.
DR EMBL; BC132467; AAI32468.1; -; mRNA.
DR CCDS; CCDS22119.1; -. [Q8C5P7-1]
DR RefSeq; NP_776105.1; NM_173744.4. [Q8C5P7-1]
DR RefSeq; XP_006508967.1; XM_006508904.1.
DR RefSeq; XP_017168463.1; XM_017312974.1.
DR AlphaFoldDB; Q8C5P7; -.
DR BioGRID; 215184; 1.
DR IntAct; Q8C5P7; 1.
DR STRING; 10090.ENSMUSP00000058371; -.
DR iPTMnet; Q8C5P7; -.
DR PhosphoSitePlus; Q8C5P7; -.
DR EPD; Q8C5P7; -.
DR MaxQB; Q8C5P7; -.
DR PaxDb; Q8C5P7; -.
DR PeptideAtlas; Q8C5P7; -.
DR PRIDE; Q8C5P7; -.
DR ProteomicsDB; 262749; -. [Q8C5P7-1]
DR ProteomicsDB; 262750; -. [Q8C5P7-2]
DR Antibodypedia; 2036; 50 antibodies from 13 providers.
DR DNASU; 72148; -.
DR Ensembl; ENSMUST00000062613; ENSMUSP00000058371; ENSMUSG00000050052. [Q8C5P7-1]
DR GeneID; 72148; -.
DR KEGG; mmu:72148; -.
DR UCSC; uc009kyv.2; mouse. [Q8C5P7-1]
DR CTD; 157695; -.
DR MGI; MGI:1919398; Tdrp.
DR VEuPathDB; HostDB:ENSMUSG00000050052; -.
DR eggNOG; ENOG502RYNW; Eukaryota.
DR GeneTree; ENSGT00390000017888; -.
DR HOGENOM; CLU_094260_0_0_1; -.
DR InParanoid; Q8C5P7; -.
DR OMA; GHCFWDS; -.
DR OrthoDB; 1500031at2759; -.
DR TreeFam; TF335521; -.
DR BioGRID-ORCS; 72148; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tdrp; mouse.
DR PRO; PR:Q8C5P7; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8C5P7; protein.
DR Bgee; ENSMUSG00000050052; Expressed in placenta labyrinth and 227 other tissues.
DR ExpressionAtlas; Q8C5P7; baseline and differential.
DR Genevisible; Q8C5P7; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISO:MGI.
DR InterPro; IPR031399; TDRP.
DR Pfam; PF15683; TDRP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..182
FT /note="Testis development-related protein"
FT /id="PRO_0000308220"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q498E2"
FT VAR_SEQ 34..182
FT /note="SGASLRGWKEATSLFNKDDEEHLLETSRSPKSKGTNQRLREELKAEKKSGFW
FT DALVLKQNAQPKKPDQIEGWEPPKLTAEDVVADHTEDDRSGCPPWSAWEDDTKGSTKYT
FT SLANSASSSRWSLRSAGKLVSIRRQSKGHLTETCEEGE -> SVRARVGAQVRAAGCSG
FT GRAQVHGVACRVRTWQGPDASRGCEVTAPEDPSDEWPGPTGRGPQSQHVWGTAGTRTPG
FT TFRTGRRRCPSLCCHKGFGVRLETPGTRGDRFQARYFYSGVGETEKS (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028924"
SQ SEQUENCE 182 AA; 20186 MW; 375805676B69D899 CRC64;
MWKLSRSRVL LDEPPEEEDV LRGAPPASAA APASGASLRG WKEATSLFNK DDEEHLLETS
RSPKSKGTNQ RLREELKAEK KSGFWDALVL KQNAQPKKPD QIEGWEPPKL TAEDVVADHT
EDDRSGCPPW SAWEDDTKGS TKYTSLANSA SSSRWSLRSA GKLVSIRRQS KGHLTETCEE
GE
