ID   TDRP_RAT                Reviewed;         182 AA.
AC   Q498E2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Testis development-related protein;
GN   Name=Tdrp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA   Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
RT   "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT   regulation of aquaporin-2 phosphorylation at two sites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
RN   [3]
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=20170638; DOI=10.1016/j.bbrc.2010.02.061;
RA   Wang X., Jiang H., Zhou W., Zhang Z., Yang Z., Lu Y., Lu B., Wang X.,
RA   Ding Q., Hu R.;
RT   "Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells
RT   of testis and its relationship with spermatogenesis.";
RL   Biochem. Biophys. Res. Commun. 394:29-35(2010).
CC   -!- FUNCTION: Contributes to normal sperm motility, but not essential for
CC       male fertility. {ECO:0000250|UniProtKB:Q8C5P7}.
CC   -!- SUBUNIT: Interacts with PRM2. {ECO:0000250|UniProtKB:Q8C5P7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20170638}. Cytoplasm
CC       {ECO:0000269|PubMed:20170638}. Note=Mainly nuclear. Also detected in
CC       cytoplasm near the midpiece of the flagellum.
CC       {ECO:0000250|UniProtKB:Q8C5P7}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in testis.
CC       {ECO:0000269|PubMed:20170638}.
CC   -!- DEVELOPMENTAL STAGE: In testis: weakly expressed in newborns, increases
CC       remarkably at 3 weeks postpartum, and peaks at 2 months postpartum (at
CC       protein level). {ECO:0000269|PubMed:20170638}.
CC   -!- SIMILARITY: Belongs to the TDRP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI00252.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC100251; AAI00252.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001094261.1; NM_001100791.1.
DR   AlphaFoldDB; Q498E2; -.
DR   STRING; 10116.ENSRNOP00000028935; -.
DR   iPTMnet; Q498E2; -.
DR   PhosphoSitePlus; Q498E2; -.
DR   jPOST; Q498E2; -.
DR   PaxDb; Q498E2; -.
DR   GeneID; 498662; -.
DR   KEGG; rno:498662; -.
DR   CTD; 157695; -.
DR   RGD; 1559733; Tdrp.
DR   VEuPathDB; HostDB:ENSRNOG00000027245; -.
DR   eggNOG; ENOG502RYNW; Eukaryota.
DR   HOGENOM; CLU_094260_0_0_1; -.
DR   InParanoid; Q498E2; -.
DR   OMA; GHCFWDS; -.
DR   OrthoDB; 1500031at2759; -.
DR   PhylomeDB; Q498E2; -.
DR   TreeFam; TF335521; -.
DR   PRO; PR:Q498E2; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000027245; Expressed in testis and 19 other tissues.
DR   ExpressionAtlas; Q498E2; baseline and differential.
DR   Genevisible; Q498E2; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR   InterPro; IPR031399; TDRP.
DR   Pfam; PF15683; TDRP; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..182
FT                   /note="Testis development-related protein"
FT                   /id="PRO_0000308221"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         7
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:16641100"
SQ   SEQUENCE   182 AA;  20171 MW;  5B3DD00F85D18190 CRC64;
     MWKLSRSRVL LDEPPEEEDV LRGASPASAA AQAPGASLRG WKEATSLFNK DDEERLLETS
     RSSKSKGTNV RLKEELKAEK KSGFWDALVL KQNVQPKKPD QMEGWEPPKL TAEDVATDHT
     EDGISSLPPW SAWEDDTKGS TKYTSLASSA SSSRWSLRSA GKLVSIRRQS KGHLTETCEE
     VE