BR2RD_PELRI
ID BR2RD_PELRI Reviewed; 29 AA.
AC P86025;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 1.
DT 25-MAY-2022, entry version 20.
DE RecName: Full=Brevinin-2Rd {ECO:0000303|PubMed:18855342};
OS Pelophylax ridibundus (Marsh frog) (Rana ridibunda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX NCBI_TaxID=8406;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND DISULFIDE BOND.
RC TISSUE=Skin secretion {ECO:0000269|PubMed:18855342};
RX PubMed=18855342; DOI=10.1002/rcm.3759;
RA Samgina T.Y., Artemenko K.A., Gorshkov V.A., Ogourtsov S.V., Zubarev R.A.,
RA Lebedev A.T.;
RT "De novo sequencing of peptides secreted by the skin glands of the
RT caucasian green frog Rana ridibunda.";
RL Rapid Commun. Mass Spectrom. 22:3517-3525(2008).
CC -!- FUNCTION: Antimicrobial peptide. {ECO:0000250|UniProtKB:P40840}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=3012; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:18855342};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000255}.
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DR AlphaFoldDB; P86025; -.
DR SMR; P86025; -.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR012521; Antimicrobial_frog_2.
DR Pfam; PF08023; Antimicrobial_2; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Secreted.
FT PEPTIDE 1..29
FT /note="Brevinin-2Rd"
FT /evidence="ECO:0000269|PubMed:18855342"
FT /id="PRO_0000361066"
FT DISULFID 23..29
FT /evidence="ECO:0000269|PubMed:18855342"
SQ SEQUENCE 29 AA; 3016 MW; F8099AFDA6CE8615 CRC64;
GILDSLKNLA KNAAQILLNK ASCKLSGQC