ID   TE1_HUMLU               Reviewed;         217 AA.
AC   S4TEF7;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Acyl-acyl carrier protein thioesterase TE1, chloroplastic {ECO:0000303|PubMed:23300257};
DE            Short=HlTE1 {ECO:0000303|PubMed:23300257};
DE            EC=3.1.2.- {ECO:0000250|UniProtKB:Q9C7I5};
DE   AltName: Full=Acyl-ACP thioesterase TE1 {ECO:0000303|PubMed:23300257};
DE   AltName: Full=Acyl-lipid thioesterase 1 {ECO:0000303|PubMed:23300257};
DE   Flags: Precursor;
GN   Name=TE1 {ECO:0000303|PubMed:23300257};
OS   Humulus lupulus (European hop).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Humulus.
OX   NCBI_TaxID=3486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP   NOMENCLATURE.
RC   STRAIN=cv. Nugget;
RX   PubMed=23300257; DOI=10.1093/mp/sst004;
RA   Xu H., Zhang F., Liu B., Huhman D.V., Sumner L.W., Dixon R.A., Wang G.;
RT   "Characterization of the formation of branched short-chain fatty acid:CoAs
RT   for bitter acid biosynthesis in hop glandular trichomes.";
RL   Mol. Plant 6:1301-1317(2013).
CC   -!- FUNCTION: Acyl-ACP thioesterase involved in the production of fatty
CC       acids and beta-keto fatty acids (By similarity). May play a role in
CC       cuticular wax synthesis (By similarity).
CC       {ECO:0000250|UniProtKB:Q9C7I5}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed at low levels in glandular
CC       trichomes (lupulin glands), and, to a lower extent, in stems, leaves,
CC       flowers and cones. {ECO:0000269|PubMed:23300257}.
CC   -!- SIMILARITY: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
CC       {ECO:0000305}.
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DR   EMBL; JX878391; AGA17931.1; -; mRNA.
DR   AlphaFoldDB; S4TEF7; -.
DR   SMR; S4TEF7; -.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR006683; Thioestr_dom.
DR   Pfam; PF03061; 4HBT; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   2: Evidence at transcript level;
KW   Chloroplast; Hydrolase; Lipid metabolism; Plastid; Transit peptide.
FT   TRANSIT         1..56
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           57..217
FT                   /note="Acyl-acyl carrier protein thioesterase TE1,
FT                   chloroplastic"
FT                   /id="PRO_0000452959"
FT   ACT_SITE        97
FT                   /evidence="ECO:0000250|UniProtKB:P56653,
FT                   ECO:0000250|UniProtKB:Q9C7I5"
SQ   SEQUENCE   217 AA;  24589 MW;  C681E70119FB27E7 CRC64;
     MLQTISLLPA YNKPPVATLL HPHRSSSSSP LPCGHVSPVT HGGLIMNPQK RLRSFSANMK
     CSSTNSIIDD TIIRNGQRIM MSEYFDVQLK VRDYELDQYG VVNNAAYASY CQHGCIELME
     SIGVSGDRIS RTGDALAISE LSIKFLSPLR GGDKFVMKVR YCRISAVRTY FEHKIFKLPN
     REPILEAKAT TIWLNKKYRP TRMPLEITSL LDKFFTR