TE2IP_CHICK
ID TE2IP_CHICK Reviewed; 329 AA.
AC Q7T0L4; Q8JGU1;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Telomeric repeat-binding factor 2-interacting protein 1;
DE Short=TERF2-interacting telomeric protein 1;
DE Short=TRF2-interacting telomeric protein 1;
DE AltName: Full=Repressor/activator protein 1 homolog;
DE Short=RAP1 homolog;
DE Short=cRAP1;
GN Name=TERF2IP; Synonyms=RAP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, AND
RP INTERACTION WITH TERF2.
RX PubMed=14659874; DOI=10.1016/j.gene.2003.08.026;
RA Tan M., Wei C., Price C.M.;
RT "The telomeric protein Rap1 is conserved in vertebrates and is expressed
RT from a bidirectional promoter positioned between the Rap1 and KARS genes.";
RL Gene 323:1-10(2003).
CC -!- FUNCTION: Acts both as a regulator of telomere function and as a
CC transcription regulator. Involved in the regulation of telomere length
CC and protection as a component of the shelterin complex (telosome). Does
CC not bind DNA directly: recruited to telomeric double-stranded 5'-
CC TTAGGG-3' repeats via its interaction with terf2. Independently of its
CC function in telomeres, also acts as a transcription regulator:
CC recruited to extratelomeric 5'-TTAGGG-3' sites via its association with
CC terf2 or other factors, and regulates gene expression (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Component of the shelterin complex (telosome) (By
CC similarity). Interacts with terf2; the interaction is direct.
CC {ECO:0000250, ECO:0000269|PubMed:14659874}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14659874}.
CC Chromosome, telomere {ECO:0000269|PubMed:14659874}.
CC -!- MISCELLANEOUS: Shares a bidirectional promoter with KARS.
CC {ECO:0000305|PubMed:14659874}.
CC -!- SIMILARITY: Belongs to the RAP1 family. {ECO:0000305}.
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DR EMBL; AY083608; AAM03315.1; -; mRNA.
DR EMBL; AY083908; AAM08123.1; -; Genomic_DNA.
DR RefSeq; NP_989799.1; NM_204468.1.
DR AlphaFoldDB; Q7T0L4; -.
DR SMR; Q7T0L4; -.
DR BioGRID; 675420; 1.
DR STRING; 9031.ENSGALP00000001323; -.
DR PaxDb; Q7T0L4; -.
DR GeneID; 395122; -.
DR KEGG; gga:395122; -.
DR CTD; 54386; -.
DR VEuPathDB; HostDB:geneid_395122; -.
DR eggNOG; ENOG502RPXS; Eukaryota.
DR HOGENOM; CLU_028192_0_0_1; -.
DR InParanoid; Q7T0L4; -.
DR OrthoDB; 602157at2759; -.
DR PhylomeDB; Q7T0L4; -.
DR TreeFam; TF332348; -.
DR Reactome; R-GGA-418124; Telomere maintenance.
DR PRO; PR:Q7T0L4; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0070187; C:shelterin complex; IBA:GO_Central.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0048239; P:negative regulation of DNA recombination at telomere; ISS:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR Gene3D; 1.10.10.2170; -; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR021661; Rap1_C.
DR InterPro; IPR038104; Rap1_C_sf.
DR InterPro; IPR015010; Rap1_Myb_dom.
DR InterPro; IPR039595; TE2IP/Rap1.
DR PANTHER; PTHR16466; PTHR16466; 2.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF08914; Myb_DNA-bind_2; 1.
DR Pfam; PF11626; Rap1_C; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
PE 1: Evidence at protein level;
KW Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW Transcription; Transcription regulation.
FT CHAIN 1..329
FT /note="Telomeric repeat-binding factor 2-interacting
FT protein 1"
FT /id="PRO_0000398642"
FT DOMAIN 63..86
FT /note="BRCT"
FT DOMAIN 94..153
FT /note="Myb-like"
FT REGION 179..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 313..329
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 180..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 121
FT /note="Missing (in Ref. 1; AAM08123)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 36182 MW; 0EF989CD7752F3CB CRC64;
MAAPPRKVFV WEDGTPMRFY IRPGMAKLRL APLLLAGGAG LCRVQEPGAV HLVQPGEPAP
DGAVSTDYVV ACVESQRRLP LDLYRHSGPA PLAASPRGRL PFTEAEDAAL LRAVRERSGA
PRVSGTALWK ELECTGLTRH SWQAMRDRYL RHLRPLHRES QQTEEAAAPM GIFEAANREF
ESSESGSDTS DTPDELPLQN GEGTFPLEAA SGLQTGLDDC ALPAAQGENK QTNTFSDSSK
AEEAAQIIQH FMEEFHTDLL TVTQALLKNS GEVEATSYYL HAGQRLDGYP VWSREDDLEL
QKDDEDVRSK LIAKFGAENV ARRVAFRKS
