ID   TE80_TETTH              Reviewed;         719 AA.
AC   Q94818;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Telomerase component p80;
DE            EC=2.7.7.49;
OS   Tetrahymena thermophila.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=7774009; DOI=10.1016/0092-8674(95)90529-4;
RA   Collins K., Kobayashi R., Greider C.W.;
RT   "Purification of Tetrahymena telomerase and cloning of genes encoding the
RT   two protein components of the enzyme.";
RL   Cell 81:677-686(1995).
CC   -!- FUNCTION: Ribonucleoprotein DNA polymerase that catalyzes the de novo
CC       synthesis of telomeric simple sequence repeats. Subunit p80 binds
CC       tightly and specifically to the telomerase RNA suggesting its
CC       association with a region of RNA secondary structure.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
CC   -!- SUBUNIT: Telomerase consist of two subunit, p80 and p95 that form a
CC       1:1:1 complex with the 159 nt telomerase RNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC       {ECO:0000305}.
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DR   EMBL; U25641; AAC46601.1; -; mRNA.
DR   PIR; S55939; S55939.
DR   AlphaFoldDB; Q94818; -.
DR   DIP; DIP-908N; -.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR008858; TROVE_dom.
DR   InterPro; IPR037214; TROVE_dom_sf.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF05731; TROVE; 1.
DR   SUPFAM; SSF140864; SSF140864; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50988; TROVE; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Nucleotidyltransferase;
KW   Nucleus; RNA-directed DNA polymerase; Telomere; Transferase.
FT   CHAIN           1..719
FT                   /note="Telomerase component p80"
FT                   /id="PRO_0000072476"
FT   DOMAIN          24..508
FT                   /note="TROVE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00343"
SQ   SEQUENCE   719 AA;  82352 MW;  8A945A71189CA99C CRC64;
     MEIENNQAQQ PKAEKLWWEL ELEMQENQND IQVRVKIDDP KQYLVNVTAA CLLQEGSYYQ
     DKDERRYIIT KALLEVAESD PEFICQLAVY IRNELYIRTT TNYIVAFCVV HKNTQPFIEK
     YFNKAVLLPN DLLEVCEFAQ VLYIFDATEF KNLYLDRILS QDIRKELTFR KCLQRCVRSK
     FSEFNEYQLG KYCTESQRKK TMFRYLSVTN KQKWDQTKKK RKENLLTKLQ AIKESEDKSK
     RETGDIMNVE DAIKALKPAV MKKIAKRQNA MKKHMKAPKI PNSTLESKYL TFKDLIKFCH
     ISEPKERVYK ILGKKYPKTE EEYKAAFGDS ASAPFNPELA GKRMKIEISK TWENELSAKG
     NTAEVWDNLI SSNQLPYMAM LRNLSNILKA GVSDTTHSIV INKICEPKAV ENSKMFPLQF
     FSAIEAVNEA VTKGFKAKKR ENMNLKGQIE AVKEVVEKTD EEKKDMELEQ TEEGEFVKVN
     EGIGKQYINS IELAIKIAVN KNLDEIKGHT AIFSDVSGSM STSMSGGAKK YGSVRTCLEC
     ALVLGLMVKQ RCEKSSFYIF SSPSSQCNKC YLEVDLPGDE LRPSMQKLLQ EKGKLGGGTD
     FPYECIDEWT KNKTHVDNIV ILSDMMIAEG YSDINVRGSS IVNSIKKYKD EVNPNIKIFA
     VDLEGYGKCL NLGDEFNENN YIKIFGMSDS ILKFISAKQG GANMVEVIKN FALQKIGQK