ID   TE95_TETTH              Reviewed;         872 AA.
AC   Q94819;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Telomerase component p95;
DE            EC=2.7.7.49;
OS   Tetrahymena thermophila.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=7774009; DOI=10.1016/0092-8674(95)90529-4;
RA   Collins K., Kobayashi R., Greider C.W.;
RT   "Purification of Tetrahymena telomerase and cloning of genes encoding the
RT   two protein components of the enzyme.";
RL   Cell 81:677-686(1995).
CC   -!- FUNCTION: Ribonucleoprotein DNA polymerase that catalyzes the de novo
CC       synthesis of telomeric simple sequence repeats. Subunit p95 contains
CC       some or all of the template-independent primer DNA-binding site termed
CC       the anchor site.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
CC   -!- SUBUNIT: Telomerase consist of two subunit, p80 and p95 that form a
CC       1:1:1 complex with the 159 nt telomerase RNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC       {ECO:0000305}.
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DR   EMBL; U25642; AAC46602.1; -; mRNA.
DR   PIR; S55940; S55940.
DR   AlphaFoldDB; Q94819; -.
DR   SMR; Q94819; -.
DR   PRIDE; Q94819; -.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Nucleotidyltransferase;
KW   Nucleus; RNA-directed DNA polymerase; Telomere; Transferase.
FT   CHAIN           1..872
FT                   /note="Telomerase component p95"
FT                   /id="PRO_0000072477"
FT   REGION          55..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   872 AA;  102946 MW;  78AFF4CD829651FA CRC64;
     MSRRNQKKPQ APIGNETNLD FVLQNLEVYK SQIEHYKTQQ QQIKEEDLKL LKFKNQDQDG
     NSGNDDDDEE NNSNKQQELL RRVNQIKQQV QLIKKVGSKV EKDLNLNEDE NKKNGLSEQQ
     VKEEQLRTIT EEQVKYQNLV FNMDYQLDLN ESGGHRRHRR ETDYDTEKWF EISHDQKNYV
     SIYANQKTSY CWWLKDYFNK NNYDHLNVSI NRLETEAEFY AFDDFSQTIK LTNNSYQTVN
     IDVNFDNNLC ILALLRFLLS LERFNILNIR SSYTRNQYNF EKIGELLETI FAVVFSHRHL
     QGIHLQVPCE AFQYLVNSSS QISVKDSQLQ VYSFSTDLKL VDTNKVQDYF KFLQEFPRLT
     HVSQQAIPVS ATNAVENLNV LLKKVKHANL NLVSIPTQFN FDFYFVNLQH LKLEFGLEPN
     ILTKQKLENL LLSIKQSKNL KFLRLNFYTY VAQETSRKQI LKQATTIKNL KNNKNQEETP
     ETKDETPSES TSGMKFFDHL SELTELEDFS VNLQATQEIY DSLHKLLIRS TNLKKFKLSY
     KYEMEKSKMD TFIDLKNIYE TLNNLKRCSV NISNPHGNIS YELTNKDSTF YKFKLTLNQE
     LQHAKYTFKQ NEFQFNNVKS AKIESSSLES LEDIDSLCKS IASCKNLQNV NIIASLLYPN
     NIQKNPFNKP NLLFFKQFEQ LKNLENVSIN CILDQHILNS ISEFLEKNKK IKAFILKRYY
     LLQYYLDYTK LFKTLQQLPE LNQVYINQQL EELTVSEVHK QVWENHKQKA FYEPLCEFIK
     ESSQTLQLID FDQNTVSDDS IKKILESISE SKYHHYLRLN PSQSSSLIKS ENEEIQELLK
     ACDEKGVLVK AYYKFPLCLP TGTYYDYNSD RW