ID   TEAC_HALED              Reviewed;         427 AA.
AC   E1VBK3; Q8VPB1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Ectoine TRAP transporter large permease protein TeaC;
GN   Name=teaC; OrderedLocusNames=HELO_4276;
OS   Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198
OS   / 1H9).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=768066;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE,
RP   AND GENE NAME.
RC   STRAIN=ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9;
RX   PubMed=12003950; DOI=10.1128/jb.184.11.3078-3085.2002;
RA   Grammann K., Volke A., Kunte H.J.;
RT   "New type of osmoregulated solute transporter identified in halophilic
RT   members of the bacteria domain: TRAP transporter TeaABC mediates uptake of
RT   ectoine and hydroxyectoine in Halomonas elongata DSM 2581(T).";
RL   J. Bacteriol. 184:3078-3085(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9;
RX   PubMed=20849449; DOI=10.1111/j.1462-2920.2010.02336.x;
RA   Schwibbert K., Marin-Sanguino A., Bagyan I., Heidrich G., Lentzen G.,
RA   Seitz H., Rampp M., Schuster S.C., Klenk H.P., Pfeiffer F., Oesterhelt D.,
RA   Kunte H.J.;
RT   "A blueprint of ectoine metabolism from the genome of the industrial
RT   producer Halomonas elongata DSM 2581(T).";
RL   Environ. Microbiol. 13:1973-1994(2011).
CC   -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC       transport system TeaABC involved in the uptake of ectoine and
CC       hydroxyectoine in response to osmotic upshock. Probably functions as a
CC       recovery system for synthesized ectoine that leaks out of the cell.
CC       {ECO:0000269|PubMed:12003950}.
CC   -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC       protein TeaA, and the two transmembrane proteins TeaB and TeaC.
CC       {ECO:0000269|PubMed:12003950}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Deletion abolishes accumulation of ectoine from
CC       the medium. {ECO:0000269|PubMed:12003950}.
CC   -!- SIMILARITY: Belongs to the TRAP transporter large permease family.
CC       {ECO:0000305}.
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DR   EMBL; AY061646; AAL29686.1; -; Genomic_DNA.
DR   EMBL; FN869568; CBV44160.1; -; Genomic_DNA.
DR   RefSeq; WP_013334030.1; NC_014532.2.
DR   AlphaFoldDB; E1VBK3; -.
DR   SMR; E1VBK3; -.
DR   STRING; 768066.HELO_4276; -.
DR   TCDB; 2.A.56.1.11; the tripartite atp-independent periplasmic transporter (trap-t) family.
DR   EnsemblBacteria; CBV44160; CBV44160; HELO_4276.
DR   KEGG; hel:HELO_4276; -.
DR   eggNOG; COG1593; Bacteria.
DR   HOGENOM; CLU_019824_4_1_6; -.
DR   OMA; AFSWYIS; -.
DR   Proteomes; UP000008707; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010656; DctM.
DR   InterPro; IPR004681; TRAP_DctM.
DR   PANTHER; PTHR33362; PTHR33362; 1.
DR   Pfam; PF06808; DctM; 1.
DR   PIRSF; PIRSF006066; HI0050; 1.
DR   TIGRFAMs; TIGR00786; dctM; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..427
FT                   /note="Ectoine TRAP transporter large permease protein
FT                   TeaC"
FT                   /id="PRO_0000428829"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   427 AA;  44955 MW;  C0FFCC9D78809558 CRC64;
     MTTIMVATMI GLLLLGFPMM IPLATASIIG FFMMFGGLGQ METLIQQLMA GIRPASLIAV
     PMFILAADIM TRGQSANRLI NMVMAFIGHI KGGLAVSTAA SCTLFGAVSG STQATVVAVG
     SPLRPRMLKA GYSDSFSLAL IINSSDIAFL IPPSIGMIIY GIISGTSIGE LFIAGIGPGL
     MILVMFAIYC VIYAIVRGVP TEPKASWGER FSAVRLALWP LGFPVIIIGG IYGGIFSPTE
     AAAACVLYAV LLEFVVFRSL KISDIYAIAK STGLITAVVF ILVAVGNSFS WIISFAQIPQ
     AILEAVGINE AGPTGVLIAI CVAFFVACMF VDPIVVILVL TPVFAPAIEA TGLDPVLVGI
     LITLQVAIGS ATPPFGCDIF TAIAIFKRPY LDVIKGTPPF IFMLVLAAAL LILFPQIALF
     LRDLAFR