ID   TEAD3_CHICK             Reviewed;         433 AA.
AC   Q90701; Q90702;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Transcriptional enhancer factor TEF-5;
DE   AltName: Full=Cardiac-enriched TEA domain transcription factor 1;
DE            Short=DTEF-1;
DE   AltName: Full=TEA domain family member 3;
DE            Short=TEAD-3;
GN   Name=TEAD3; Synonyms=DTEF1, TEF5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS DTEF-1A AND DTEF-1B).
RC   TISSUE=Heart;
RX   PubMed=8626520; DOI=10.1074/jbc.271.14.8260;
RA   Azakie A., Larkin S.B., Farrance I.K., Grenningloh G., Ordahl C.P.;
RT   "DTEF-1, a novel member of the transcription enhancer factor-1 (TEF-1)
RT   multigene family.";
RL   J. Biol. Chem. 271:8260-8265(1996).
CC   -!- FUNCTION: Transcription factor which plays a key role in the Hippo
CC       signaling pathway, a pathway involved in organ size control and tumor
CC       suppression by restricting proliferation and promoting apoptosis. The
CC       core of this pathway is composed of a kinase cascade wherein MST1/MST2,
CC       in complex with its regulatory protein SAV1, phosphorylates and
CC       activates LATS1/2 in complex with its regulatory protein MOB1, which in
CC       turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=DTEF-1A;
CC         IsoId=Q90701-1; Sequence=Displayed;
CC       Name=DTEF-1B;
CC         IsoId=Q90701-2; Sequence=VSP_006389;
CC   -!- TISSUE SPECIFICITY: High levels in cardiac muscle, low in skeletal
CC       muscle. Intermediate levels in gizzard and lung, low levels in kidney.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC59786.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};
CC       Sequence=AAC59787.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};
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DR   EMBL; U46127; AAC59786.1; ALT_SEQ; mRNA.
DR   EMBL; U46128; AAC59787.1; ALT_SEQ; mRNA.
DR   PIR; T09284; T09284.
DR   AlphaFoldDB; Q90701; -.
DR   SMR; Q90701; -.
DR   STRING; 9031.ENSGALP00000001405; -.
DR   VEuPathDB; HostDB:geneid_395810; -.
DR   eggNOG; KOG3841; Eukaryota.
DR   InParanoid; Q90701; -.
DR   OrthoDB; 823827at2759; -.
DR   PhylomeDB; Q90701; -.
DR   PRO; PR:Q90701; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR   GO; GO:0035329; P:hippo signaling; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 6.10.20.40; -; 1.
DR   InterPro; IPR000818; TEA/ATTS_dom.
DR   InterPro; IPR038096; TEA/ATTS_sf.
DR   InterPro; IPR027253; TEF-5.
DR   InterPro; IPR016361; TEF_metazoa.
DR   InterPro; IPR041086; YBD.
DR   Pfam; PF01285; TEA; 1.
DR   Pfam; PF17725; YBD; 1.
DR   PIRSF; PIRSF002603; TEF; 1.
DR   PIRSF; PIRSF500720; TEF-5; 1.
DR   PRINTS; PR00065; TEADOMAIN.
DR   SMART; SM00426; TEA; 1.
DR   PROSITE; PS00554; TEA_1; 1.
DR   PROSITE; PS51088; TEA_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..433
FT                   /note="Transcriptional enhancer factor TEF-5"
FT                   /id="PRO_0000205936"
FT   DNA_BIND        28..104
FT                   /note="TEA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00505"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          171..433
FT                   /note="Transcriptional activation"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         87..110
FT                   /note="KKQVSSHLQVLARREISGDSSKLK -> RKQVSSHIQVLARKKVRSTGWHQ
FT                   (in isoform DTEF-1B)"
FT                   /evidence="ECO:0000303|PubMed:8626520"
FT                   /id="VSP_006389"
SQ   SEQUENCE   433 AA;  48514 MW;  81077A9C4B0F245C CRC64;
     MASNSWNASS SPGEGREDGQ DGMDKSLDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL
     SDEGKMYGRN ELIARYIKLR TGKTRTKKQV SSHLQVLARR EISGDSSKLK AMNLDQVSKD
     KAFQSMASMS SAQIVSASVL QNKLSPPPPL PQAVFSAAPR FWSGPIPGQP GPSQDIKPFA
     QPAYPIQPPM PPSLASYEPL APLPPAASAV PVWQDRTIAS AKLRLLEYSA FMEVPRDAET
     YSKHLFVHIG QTNPSYSDPL LEAMDIRQIY DKFPEKKGGL KELYERGPQN SFFLLKFWAD
     LNSTIQDGPG TFYGVSSQYS SAENMTITVS TKVCSFGKQV VEKVETEYAR LENSRFVYRI
     HRSPMCEYMI NFIHKLKHLP EKYMMNSVLE NFTILQVVTN RDTQETLLCI AFVFEVSTSE
     HGAQHHVYKL VKD