ID   BR2TA_RANTE             Reviewed;          74 AA.
AC   P82268;
DT   04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Brevinin-2Ta;
DE   Flags: Precursor;
OS   Rana temporaria (European common frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=8407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RA   Simmaco M., Miele R., Mangoni M.L., Barra D.;
RT   "A cDNA clone encoding brevinin 2Ta from Rana temporaria.";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antimicrobial peptide. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   EMBL; AJ251567; CAB61442.1; -; mRNA.
DR   AlphaFoldDB; P82268; -.
DR   SMR; P82268; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF08023; Antimicrobial_2; 1.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   2: Evidence at transcript level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..41
FT                   /id="PRO_0000003449"
FT   PEPTIDE         42..74
FT                   /note="Brevinin-2Ta"
FT                   /id="PRO_0000003450"
FT   DISULFID        68..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   74 AA;  8162 MW;  55E0FDF790B78F75 CRC64;
     MFTMKKSLLL FFFLGTISLS LCQEERNADE DDGEMTEEEK RGILDTLKNL AKTAGKGILK
     SLVNTASCKL SGQC