TEAD3_MOUSE
ID TEAD3_MOUSE Reviewed; 439 AA.
AC P70210; O08516; O70623; P70209;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Transcriptional enhancer factor TEF-5;
DE AltName: Full=DTEF-1;
DE AltName: Full=ETF-related factor 1;
DE Short=ETFR-1;
DE AltName: Full=TEA domain family member 3;
DE Short=TEAD-3;
GN Name=Tead3; Synonyms=Tcf13r2, Tef5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=FVB/N, and ICR X Swiss Webster; TISSUE=Embryo;
RX PubMed=8920920; DOI=10.1006/bbrc.1996.1667;
RA Yasunami M., Suzuki K., Ohkubo H.;
RT "A novel family of TEA domain-containing transcription factors with
RT distinct spatiotemporal expression patterns.";
RL Biochem. Biophys. Res. Commun. 228:365-370(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Carcinoma;
RA Kaneko K.J., DePamphilis M.L.;
RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NIH Swiss; TISSUE=Heart;
RX PubMed=9502435; DOI=10.1089/dna.1998.17.187;
RA Yockey C.E., Shimizu N.;
RT "cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the
RT TEA/ATTS family of transcription factors.";
RL DNA Cell Biol. 17:187-196(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=9671946;
RX DOI=10.1002/(sici)1097-0177(199807)212:3<423::aid-aja10>3.0.co;2-1;
RA Jacquemin P., Sapin V., Alsat E., Evain-Brion D., Dolle P., Davidson I.;
RT "Differential expression of the TEF family of transcription factors in the
RT murine placenta and during differentiation of primary human trophoblasts in
RT vitro.";
RL Dev. Dyn. 212:423-436(1998).
CC -!- FUNCTION: Transcription factor which plays a key role in the Hippo
CC signaling pathway, a pathway involved in organ size control and tumor
CC suppression by restricting proliferation and promoting apoptosis. The
CC core of this pathway is composed of a kinase cascade wherein MST1/MST2,
CC in complex with its regulatory protein SAV1, phosphorylates and
CC activates LATS1/2 in complex with its regulatory protein MOB1, which in
CC turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
CC Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby
CC regulating cell proliferation, migration and epithelial mesenchymal
CC transition (EMT) induction (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with YAP1 and WWTR1/TAZ. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in embryos as well as in many adult
CC tissues.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC12263.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};
CC Sequence=BAA13517.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};
CC Sequence=CAA71136.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA71136.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};
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DR EMBL; D87964; BAA13517.1; ALT_SEQ; mRNA.
DR EMBL; D87963; BAA13516.1; -; mRNA.
DR EMBL; Y10027; CAA71136.1; ALT_SEQ; mRNA.
DR EMBL; AF002670; AAC12263.1; ALT_SEQ; mRNA.
DR EMBL; Y16611; CAA76315.2; -; mRNA.
DR CCDS; CCDS28577.3; -.
DR RefSeq; NP_001091696.2; NM_001098226.3.
DR RefSeq; NP_001191085.1; NM_001204156.1.
DR RefSeq; NP_035696.3; NM_011566.4.
DR AlphaFoldDB; P70210; -.
DR SMR; P70210; -.
DR BioGRID; 204100; 2.
DR CORUM; P70210; -.
DR IntAct; P70210; 1.
DR STRING; 10090.ENSMUSP00000110447; -.
DR iPTMnet; P70210; -.
DR PhosphoSitePlus; P70210; -.
DR SwissPalm; P70210; -.
DR jPOST; P70210; -.
DR MaxQB; P70210; -.
DR PaxDb; P70210; -.
DR PRIDE; P70210; -.
DR ProteomicsDB; 254691; -.
DR Antibodypedia; 6662; 262 antibodies from 30 providers.
DR DNASU; 21678; -.
DR Ensembl; ENSMUST00000154873; ENSMUSP00000118582; ENSMUSG00000002249.
DR Ensembl; ENSMUST00000156862; ENSMUSP00000115443; ENSMUSG00000002249.
DR GeneID; 21678; -.
DR KEGG; mmu:21678; -.
DR UCSC; uc008bqr.2; mouse.
DR CTD; 7005; -.
DR MGI; MGI:109241; Tead3.
DR eggNOG; KOG3841; Eukaryota.
DR GeneTree; ENSGT00950000182956; -.
DR InParanoid; P70210; -.
DR OrthoDB; 823827at2759; -.
DR Reactome; R-MMU-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
DR Reactome; R-MMU-8951671; RUNX3 regulates YAP1-mediated transcription.
DR BioGRID-ORCS; 21678; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Tead3; mouse.
DR PRO; PR:P70210; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; P70210; protein.
DR Bgee; ENSMUSG00000002249; Expressed in lip and 219 other tissues.
DR ExpressionAtlas; P70210; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IGI:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0055059; P:asymmetric neuroblast division; ISO:MGI.
DR GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR GO; GO:0035329; P:hippo signaling; ISO:MGI.
DR GO; GO:1902459; P:positive regulation of stem cell population maintenance; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 6.10.20.40; -; 1.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR InterPro; IPR027253; TEF-5.
DR InterPro; IPR016361; TEF_metazoa.
DR InterPro; IPR041086; YBD.
DR Pfam; PF01285; TEA; 1.
DR Pfam; PF17725; YBD; 1.
DR PIRSF; PIRSF002603; TEF; 1.
DR PIRSF; PIRSF500720; TEF-5; 1.
DR PRINTS; PR00065; TEADOMAIN.
DR SMART; SM00426; TEA; 1.
DR PROSITE; PS00554; TEA_1; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q99594"
FT CHAIN 2..439
FT /note="Transcriptional enhancer factor TEF-5"
FT /id="PRO_0000205935"
FT DNA_BIND 28..104
FT /note="TEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00505"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..439
FT /note="Transcriptional activation"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q99594"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99594"
FT VARIANT 87
FT /note="R -> G"
SQ SEQUENCE 439 AA; 48938 MW; C042B19A113A7A40 CRC64;
MASNSWTANS SPGEAREDGS EGLDKGLDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL
SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK KVREYQVGIK AMNLDQVSKD
KALQSMASMS SAQIVSASVL QNKFSPPSPL PQAVFSSSSR FWSSPPLLGQ QPGPSQDIKP
FAQPAYPIQP PLPPALNSYE SLAPLPPAAA SATASAPAWQ DRTIASSRLR LLEYSAFMEV
QRDPDTYSKH LFVHIGQTNP AFSDPPLEAV DVRQIYDKFP EKKGGLKELY EKGPPNAFFL
VKFWADLNST IQEGPGAFYG VSSQYSSADS MTISVSTKVC SFGKQVVEKV ETEYARLENG
RFVYRIHRSP MCEYMINFIH KLKHLPEKYM MNSVLENFTI LQVVTSRDSQ ETLLVIAFVF
EVSTSEHGAQ HHVYKLVKD
