TEAD4_CHICK
ID TEAD4_CHICK Reviewed; 438 AA.
AC P48984;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Transcriptional enhancer factor TEF-3;
DE AltName: Full=M-CAT-binding factor;
DE AltName: Full=RTEF-1;
DE AltName: Full=TEA domain family member 4;
DE Short=TEAD-4;
DE AltName: Full=TEF-1;
GN Name=TEAD4; Synonyms=TEF-1, TEF3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).
RC TISSUE=Heart;
RX PubMed=8106348; DOI=10.1016/s0021-9258(17)41840-0;
RA Stewart A.F.R., Larkin S.B., Farrance I.K.G., Mar J.H., Hall D.E.,
RA Ordahl C.P.;
RT "Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific
RT promoters and differentially activate transcription.";
RL J. Biol. Chem. 269:3147-3150(1994).
CC -!- FUNCTION: Transcription factor which plays a key role in the Hippo
CC signaling pathway, a pathway involved in organ size control and tumor
CC suppression by restricting proliferation and promoting apoptosis. The
CC core of this pathway is composed of a kinase cascade wherein MST1/MST2,
CC in complex with its regulatory protein SAV1, phosphorylates and
CC activates LATS1/2 in complex with its regulatory protein MOB1, which in
CC turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By
CC similarity). Binds m-cat elements from muscle-specific promoters and
CC differentially activate transcription. {ECO:0000250}.
CC -!- FUNCTION: Isoform B has probably a transactivation capacity that is
CC lacking in the other isoforms. Isoform D may be defective in DNA
CC binding.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=B;
CC IsoId=P48984-1; Sequence=Displayed;
CC Name=A;
CC IsoId=P48984-2; Sequence=VSP_006391;
CC Name=C;
CC IsoId=P48984-3; Sequence=VSP_006391, VSP_006392;
CC Name=D;
CC IsoId=P48984-4; Sequence=VSP_006393;
CC -!- TISSUE SPECIFICITY: Enriched in cardiac and skeletal muscle.
CC -!- CAUTION: Was originally called TEF-1, but is the ortholog of mammalian
CC TEF-3. {ECO:0000305|PubMed:8106348}.
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DR EMBL; U04834; AAC59646.2; -; mRNA.
DR EMBL; U06848; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; U06849; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; U06850; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; U06851; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; A53042; A53042.
DR PIR; B53042; B53042.
DR PIR; C53042; C53042.
DR RefSeq; NP_001001337.1; NM_001001337.1.
DR RefSeq; NP_001001340.1; NM_001001340.1. [P48984-4]
DR RefSeq; NP_001001341.1; NM_001001341.1.
DR RefSeq; NP_990102.1; NM_204771.1.
DR AlphaFoldDB; P48984; -.
DR SMR; P48984; -.
DR STRING; 9031.ENSGALP00000029867; -.
DR PaxDb; P48984; -.
DR Ensembl; ENSGALT00000087584; ENSGALP00000062355; ENSGALG00000014342. [P48984-4]
DR GeneID; 395542; -.
DR KEGG; gga:395542; -.
DR CTD; 7004; -.
DR VEuPathDB; HostDB:geneid_395542; -.
DR eggNOG; KOG3841; Eukaryota.
DR GeneTree; ENSGT00950000182956; -.
DR InParanoid; P48984; -.
DR OrthoDB; 823827at2759; -.
DR PhylomeDB; P48984; -.
DR Reactome; R-GGA-2032785; YAP1- and WWTR1 (TAZ)-stimulated gene expression.
DR Reactome; R-GGA-8951671; RUNX3 regulates YAP1-mediated transcription.
DR PRO; PR:P48984; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000014342; Expressed in skeletal muscle tissue and 11 other tissues.
DR ExpressionAtlas; P48984; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR GO; GO:0035329; P:hippo signaling; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 6.10.20.40; -; 1.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR InterPro; IPR027255; TEF-3.
DR InterPro; IPR016361; TEF_metazoa.
DR InterPro; IPR041086; YBD.
DR Pfam; PF01285; TEA; 1.
DR Pfam; PF17725; YBD; 1.
DR PIRSF; PIRSF002603; TEF; 1.
DR PIRSF; PIRSF500722; TEF-3; 1.
DR PRINTS; PR00065; TEADOMAIN.
DR SMART; SM00426; TEA; 1.
DR PROSITE; PS00554; TEA_1; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..438
FT /note="Transcriptional enhancer factor TEF-3"
FT /id="PRO_0000205939"
FT DNA_BIND 28..104
FT /note="TEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00505"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..131
FT /note="Missing (in isoform D)"
FT /evidence="ECO:0000303|PubMed:8106348"
FT /id="VSP_006393"
FT VAR_SEQ 111..123
FT /note="Missing (in isoform A and isoform C)"
FT /evidence="ECO:0000303|PubMed:8106348"
FT /id="VSP_006391"
FT VAR_SEQ 201
FT /note="P -> PVCL (in isoform C)"
FT /evidence="ECO:0000303|PubMed:8106348"
FT /id="VSP_006392"
FT CONFLICT 1
FT /note="M -> LELLAGTI (in Ref. 1; AAC59646)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 438 AA; 49443 MW; B2B580273EB0D1BC CRC64;
MTSEWSSPAS PEGSNDSGGS EALDKPIDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL
SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KAREIQAKLK KTQVDKYDFS
SEKDQTAKDK AMQSIATMSS AQIISATAFH SKMALPGLPR SAYPAVSGFW QGALPGQAGS
SQDVKPFTQQ PYALQPSLPL PGFDSPTGLP PSSSTPAWQG RRVASSKLWM LEFSAFLEQQ
QDQDTYNKHL FVHIGQSNPS YSDPYLEAVD IRQIYDKFPE KKGGLKELFE RGPANAFFLV
KFWADLNTNI EDESRSFYGV SSQYESPENM VITCSTKVCS FGKQVVEKVE TEYAHYENGH
YAYRIHRSPL CEYMINFIHK LKHLPEKYMM NSVLENFTIL QVVTNRDTQE TLLCIAYVFE
VSASDHGAQH HIYRLVKD
