TEAN2_HUMAN
ID TEAN2_HUMAN Reviewed; 208 AA.
AC Q96MN5; Q5T702; Q8N8N2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Transcription elongation factor A N-terminal and central domain-containing protein 2;
GN Name=TCEANC2; Synonyms=C1orf83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC Q96MN5; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-5462748, EBI-741181;
CC Q96MN5; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-5462748, EBI-79165;
CC Q96MN5; Q15025: TNIP1; NbExp=4; IntAct=EBI-5462748, EBI-357849;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649,
CC ECO:0000255|PROSITE-ProRule:PRU00651}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96MN5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MN5-2; Sequence=VSP_025096;
CC -!- SIMILARITY: Belongs to the TCEANC2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK056674; BAB71250.1; -; mRNA.
DR EMBL; AK096488; BAC04803.1; -; mRNA.
DR EMBL; AL353898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035374; AAH35374.1; -; mRNA.
DR CCDS; CCDS587.1; -. [Q96MN5-1]
DR RefSeq; NP_694580.1; NM_153035.2. [Q96MN5-1]
DR AlphaFoldDB; Q96MN5; -.
DR SMR; Q96MN5; -.
DR BioGRID; 126058; 30.
DR IntAct; Q96MN5; 24.
DR STRING; 9606.ENSP00000234827; -.
DR iPTMnet; Q96MN5; -.
DR PhosphoSitePlus; Q96MN5; -.
DR BioMuta; TCEANC2; -.
DR DMDM; 74752040; -.
DR EPD; Q96MN5; -.
DR jPOST; Q96MN5; -.
DR MassIVE; Q96MN5; -.
DR MaxQB; Q96MN5; -.
DR PaxDb; Q96MN5; -.
DR PeptideAtlas; Q96MN5; -.
DR PRIDE; Q96MN5; -.
DR ProteomicsDB; 77381; -. [Q96MN5-1]
DR ProteomicsDB; 77382; -. [Q96MN5-2]
DR Antibodypedia; 33160; 158 antibodies from 20 providers.
DR DNASU; 127428; -.
DR Ensembl; ENST00000234827.6; ENSP00000234827.1; ENSG00000116205.14. [Q96MN5-1]
DR Ensembl; ENST00000648983.1; ENSP00000498109.1; ENSG00000116205.14. [Q96MN5-1]
DR GeneID; 127428; -.
DR KEGG; hsa:127428; -.
DR MANE-Select; ENST00000234827.6; ENSP00000234827.1; NM_153035.3; NP_694580.1.
DR UCSC; uc001cwt.2; human. [Q96MN5-1]
DR CTD; 127428; -.
DR DisGeNET; 127428; -.
DR GeneCards; TCEANC2; -.
DR HGNC; HGNC:26494; TCEANC2.
DR HPA; ENSG00000116205; Low tissue specificity.
DR neXtProt; NX_Q96MN5; -.
DR OpenTargets; ENSG00000116205; -.
DR PharmGKB; PA142672531; -.
DR VEuPathDB; HostDB:ENSG00000116205; -.
DR eggNOG; KOG1105; Eukaryota.
DR GeneTree; ENSGT00390000014384; -.
DR HOGENOM; CLU_086873_0_0_1; -.
DR InParanoid; Q96MN5; -.
DR PhylomeDB; Q96MN5; -.
DR TreeFam; TF331911; -.
DR PathwayCommons; Q96MN5; -.
DR SignaLink; Q96MN5; -.
DR BioGRID-ORCS; 127428; 8 hits in 1072 CRISPR screens.
DR ChiTaRS; TCEANC2; human.
DR GenomeRNAi; 127428; -.
DR Pharos; Q96MN5; Tdark.
DR PRO; PR:Q96MN5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96MN5; protein.
DR Bgee; ENSG00000116205; Expressed in sperm and 111 other tissues.
DR ExpressionAtlas; Q96MN5; baseline and differential.
DR Genevisible; Q96MN5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.472.30; -; 1.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF46942; SSF46942; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..208
FT /note="Transcription elongation factor A N-terminal and
FT central domain-containing protein 2"
FT /id="PRO_0000286574"
FT DOMAIN 40..114
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT DOMAIN 131..208
FT /note="TFIIS central"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT VAR_SEQ 1..87
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_025096"
FT CONFLICT 161
FT /note="H -> R (in Ref. 1; BAC04803)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 208 AA; 24150 MW; 7889DEFC4C016FA4 CRC64;
MDKFVIRTPR IQNSPQKKDS GGKVYKQATI ESLKRVVVVE DIKRWKTMLE LPDQTKENLV
EALQELKKKI PSREVLKSTR IGHTVNKMRK HSDSEVASLA REVYTEWKTF TEKHSNRPSI
EVRSDPKTES LRKNAQKLLS EALELKMDHL LVENIERETF HLCSRLINGP YRRTVRALVF
TLKHRAEIRA QVKSGSLPVG TFVQTHKK
