TEAN2_MOUSE
ID TEAN2_MOUSE Reviewed; 207 AA.
AC Q8R2M0; Q9CZZ2; Q9D7X9;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transcription elongation factor A N-terminal and central domain-containing protein 2;
GN Name=Tceanc2; Synonyms=Tdeanc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649,
CC ECO:0000255|PROSITE-ProRule:PRU00651}.
CC -!- SIMILARITY: Belongs to the TCEANC2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB27962.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK008715; BAB25851.1; -; mRNA.
DR EMBL; AK011991; BAB27962.1; ALT_FRAME; mRNA.
DR EMBL; BC028321; AAH28321.1; -; mRNA.
DR CCDS; CCDS18431.1; -.
DR RefSeq; NP_079893.1; NM_025617.2.
DR RefSeq; XP_006503337.1; XM_006503274.2.
DR AlphaFoldDB; Q8R2M0; -.
DR SMR; Q8R2M0; -.
DR BioGRID; 211536; 1.
DR STRING; 10090.ENSMUSP00000059741; -.
DR iPTMnet; Q8R2M0; -.
DR PhosphoSitePlus; Q8R2M0; -.
DR EPD; Q8R2M0; -.
DR MaxQB; Q8R2M0; -.
DR PaxDb; Q8R2M0; -.
DR PeptideAtlas; Q8R2M0; -.
DR PRIDE; Q8R2M0; -.
DR ProteomicsDB; 259370; -.
DR Antibodypedia; 33160; 158 antibodies from 20 providers.
DR DNASU; 66526; -.
DR Ensembl; ENSMUST00000030362; ENSMUSP00000030362; ENSMUSG00000028619.
DR Ensembl; ENSMUST00000057043; ENSMUSP00000059741; ENSMUSG00000028619.
DR Ensembl; ENSMUST00000058585; ENSMUSP00000054142; ENSMUSG00000028619.
DR GeneID; 66526; -.
DR KEGG; mmu:66526; -.
DR UCSC; uc008tzh.1; mouse.
DR CTD; 127428; -.
DR MGI; MGI:1913776; Tceanc2.
DR VEuPathDB; HostDB:ENSMUSG00000028619; -.
DR eggNOG; KOG1105; Eukaryota.
DR GeneTree; ENSGT00390000014384; -.
DR InParanoid; Q8R2M0; -.
DR OMA; FALKHKP; -.
DR OrthoDB; 1403676at2759; -.
DR PhylomeDB; Q8R2M0; -.
DR TreeFam; TF331911; -.
DR BioGRID-ORCS; 66526; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Tceanc2; mouse.
DR PRO; PR:Q8R2M0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8R2M0; protein.
DR Bgee; ENSMUSG00000028619; Expressed in granulocyte and 183 other tissues.
DR ExpressionAtlas; Q8R2M0; baseline and differential.
DR Genevisible; Q8R2M0; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.472.30; -; 1.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF46942; SSF46942; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Nucleus; Reference proteome.
FT CHAIN 1..207
FT /note="Transcription elongation factor A N-terminal and
FT central domain-containing protein 2"
FT /id="PRO_0000286575"
FT DOMAIN 39..113
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT DOMAIN 130..207
FT /note="TFIIS central"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96MN5"
FT CONFLICT 47
FT /note="M -> T (in Ref. 1; BAB27962)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 207 AA; 24200 MW; CFF7C96B78007DEA CRC64;
MDKFVIRTPR IQNSPKKKLG EKVYKQATIE SLKRVVVIED IKRWKTMLEL PDQTKENLVA
ALQELKKKMP SREVLRSTRI GHAVNKMRRH SDPEVAGLAK EVYTEWKTFI EKHLDRPSIE
VRSDPKTESF RKNAQKLLSE ALELKMDHLL VENIERETFH LCSRLINGPY RRTVRALVFT
LKHRAEIREQ VKSGALPVGT FVQTHKK
