TEANC_HUMAN
ID TEANC_HUMAN Reviewed; 351 AA.
AC Q8N8B7; A6NI06; B2RDM3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Transcription elongation factor A N-terminal and central domain-containing protein;
DE AltName: Full=TFIIS central domain-containing protein 1;
GN Name=TCEANC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-80 (ISOFORM 2), AND VARIANT LEU-163.
RC TISSUE=Pulmonary artery, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N8B7; Q9H257: CARD9; NbExp=3; IntAct=EBI-954696, EBI-751319;
CC Q8N8B7; Q8NA61: CBY2; NbExp=3; IntAct=EBI-954696, EBI-741724;
CC Q8N8B7; Q8N4Y2: CRACR2B; NbExp=3; IntAct=EBI-954696, EBI-10267893;
CC Q8N8B7; Q96S65: CSRNP1; NbExp=3; IntAct=EBI-954696, EBI-4311573;
CC Q8N8B7; O75553: DAB1; NbExp=3; IntAct=EBI-954696, EBI-7875264;
CC Q8N8B7; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-954696, EBI-10175124;
CC Q8N8B7; O95073: FSBP; NbExp=3; IntAct=EBI-954696, EBI-1059030;
CC Q8N8B7; A1L4K1: FSD2; NbExp=3; IntAct=EBI-954696, EBI-5661036;
CC Q8N8B7; Q08379: GOLGA2; NbExp=3; IntAct=EBI-954696, EBI-618309;
CC Q8N8B7; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-954696, EBI-2549423;
CC Q8N8B7; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-954696, EBI-2125614;
CC Q8N8B7; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-954696, EBI-10172290;
CC Q8N8B7; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-954696, EBI-10172511;
CC Q8N8B7; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-954696, EBI-3958099;
CC Q8N8B7; P50221: MEOX1; NbExp=3; IntAct=EBI-954696, EBI-2864512;
CC Q8N8B7; O15344: MID1; NbExp=3; IntAct=EBI-954696, EBI-2340316;
CC Q8N8B7; Q15742: NAB2; NbExp=3; IntAct=EBI-954696, EBI-8641936;
CC Q8N8B7; Q5W0B1: OBI1; NbExp=3; IntAct=EBI-954696, EBI-2562035;
CC Q8N8B7; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-954696, EBI-302345;
CC Q8N8B7; O43805: SSNA1; NbExp=3; IntAct=EBI-954696, EBI-2515299;
CC Q8N8B7; Q15633: TARBP2; NbExp=3; IntAct=EBI-954696, EBI-978581;
CC Q8N8B7; Q08AM6: VAC14; NbExp=3; IntAct=EBI-954696, EBI-2107455;
CC Q8N8B7; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-954696, EBI-2799833;
CC Q8N8B7; O43829: ZBTB14; NbExp=3; IntAct=EBI-954696, EBI-10176632;
CC Q8N8B7-2; P78563-4: ADARB1; NbExp=3; IntAct=EBI-11955057, EBI-12002366;
CC Q8N8B7-2; Q6PJH3: AKAP9; NbExp=3; IntAct=EBI-11955057, EBI-11745576;
CC Q8N8B7-2; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-11955057, EBI-12224467;
CC Q8N8B7-2; P54253: ATXN1; NbExp=3; IntAct=EBI-11955057, EBI-930964;
CC Q8N8B7-2; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-11955057, EBI-4400025;
CC Q8N8B7-2; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-11955057, EBI-11975051;
CC Q8N8B7-2; Q9BXJ5: C1QTNF2; NbExp=3; IntAct=EBI-11955057, EBI-2817707;
CC Q8N8B7-2; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-11955057, EBI-11530605;
CC Q8N8B7-2; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-11955057, EBI-11524851;
CC Q8N8B7-2; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-11955057, EBI-10171570;
CC Q8N8B7-2; Q96M89-2: CCDC138; NbExp=3; IntAct=EBI-11955057, EBI-10972887;
CC Q8N8B7-2; P24863: CCNC; NbExp=3; IntAct=EBI-11955057, EBI-395261;
CC Q8N8B7-2; Q86X02: CDR2L; NbExp=3; IntAct=EBI-11955057, EBI-11063830;
CC Q8N8B7-2; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-11955057, EBI-739624;
CC Q8N8B7-2; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-11955057, EBI-742887;
CC Q8N8B7-2; Q8N4Y2-3: CRACR2B; NbExp=3; IntAct=EBI-11955057, EBI-11982645;
CC Q8N8B7-2; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-11955057, EBI-852194;
CC Q8N8B7-2; Q96S65: CSRNP1; NbExp=3; IntAct=EBI-11955057, EBI-4311573;
CC Q8N8B7-2; P78358: CTAG1B; NbExp=3; IntAct=EBI-11955057, EBI-1188472;
CC Q8N8B7-2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11955057, EBI-3867333;
CC Q8N8B7-2; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-11955057, EBI-11988027;
CC Q8N8B7-2; Q9NPF5: DMAP1; NbExp=3; IntAct=EBI-11955057, EBI-399105;
CC Q8N8B7-2; Q8N9I9: DTX3; NbExp=3; IntAct=EBI-11955057, EBI-2340258;
CC Q8N8B7-2; Q92997: DVL3; NbExp=3; IntAct=EBI-11955057, EBI-739789;
CC Q8N8B7-2; P63172: DYNLT1; NbExp=3; IntAct=EBI-11955057, EBI-1176455;
CC Q8N8B7-2; O60447: EVI5; NbExp=3; IntAct=EBI-11955057, EBI-852291;
CC Q8N8B7-2; Q9NTX9: FAM217B; NbExp=3; IntAct=EBI-11955057, EBI-19153639;
CC Q8N8B7-2; O15287: FANCG; NbExp=3; IntAct=EBI-11955057, EBI-81610;
CC Q8N8B7-2; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-11955057, EBI-11977403;
CC Q8N8B7-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-11955057, EBI-618309;
CC Q8N8B7-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11955057, EBI-5916454;
CC Q8N8B7-2; Q9BYE0: HES7; NbExp=3; IntAct=EBI-11955057, EBI-12163087;
CC Q8N8B7-2; O00291: HIP1; NbExp=3; IntAct=EBI-11955057, EBI-473886;
CC Q8N8B7-2; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-11955057, EBI-10961706;
CC Q8N8B7-2; P05019-2: IGF1; NbExp=3; IntAct=EBI-11955057, EBI-12837046;
CC Q8N8B7-2; Q9UKS7-2: IKZF2; NbExp=3; IntAct=EBI-11955057, EBI-11536241;
CC Q8N8B7-2; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-11955057, EBI-747204;
CC Q8N8B7-2; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-11955057, EBI-715394;
CC Q8N8B7-2; Q8NC69: KCTD6; NbExp=3; IntAct=EBI-11955057, EBI-2511344;
CC Q8N8B7-2; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-11955057, EBI-11954971;
CC Q8N8B7-2; Q8N8K9: KIAA1958; NbExp=3; IntAct=EBI-11955057, EBI-10181113;
CC Q8N8B7-2; Q96L93-6: KIF16B; NbExp=3; IntAct=EBI-11955057, EBI-10988217;
CC Q8N8B7-2; Q53G59: KLHL12; NbExp=3; IntAct=EBI-11955057, EBI-740929;
CC Q8N8B7-2; Q15323: KRT31; NbExp=3; IntAct=EBI-11955057, EBI-948001;
CC Q8N8B7-2; Q92764: KRT35; NbExp=3; IntAct=EBI-11955057, EBI-1058674;
CC Q8N8B7-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-11955057, EBI-10171697;
CC Q8N8B7-2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11955057, EBI-11959885;
CC Q8N8B7-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11955057, EBI-10171774;
CC Q8N8B7-2; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11955057, EBI-11953334;
CC Q8N8B7-2; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11955057, EBI-3958099;
CC Q8N8B7-2; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-11955057, EBI-11985629;
CC Q8N8B7-2; O95751: LDOC1; NbExp=3; IntAct=EBI-11955057, EBI-740738;
CC Q8N8B7-2; P50458: LHX2; NbExp=3; IntAct=EBI-11955057, EBI-12179869;
CC Q8N8B7-2; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-11955057, EBI-12039345;
CC Q8N8B7-2; Q9HAP6: LIN7B; NbExp=3; IntAct=EBI-11955057, EBI-821335;
CC Q8N8B7-2; Q9BX40-2: LSM14B; NbExp=3; IntAct=EBI-11955057, EBI-19133880;
CC Q8N8B7-2; P23508: MCC; NbExp=3; IntAct=EBI-11955057, EBI-307531;
CC Q8N8B7-2; D6RGH6: MCIDAS; NbExp=3; IntAct=EBI-11955057, EBI-3954372;
CC Q8N8B7-2; Q99750: MDFI; NbExp=3; IntAct=EBI-11955057, EBI-724076;
CC Q8N8B7-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11955057, EBI-16439278;
CC Q8N8B7-2; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-11955057, EBI-10172526;
CC Q8N8B7-2; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11955057, EBI-11522433;
CC Q8N8B7-2; P13349: MYF5; NbExp=3; IntAct=EBI-11955057, EBI-17491620;
CC Q8N8B7-2; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-11955057, EBI-6952711;
CC Q8N8B7-2; Q15742: NAB2; NbExp=3; IntAct=EBI-11955057, EBI-8641936;
CC Q8N8B7-2; Q8N987: NECAB1; NbExp=3; IntAct=EBI-11955057, EBI-11956853;
CC Q8N8B7-2; A6NGQ2: OOEP; NbExp=3; IntAct=EBI-11955057, EBI-18583589;
CC Q8N8B7-2; Q9H4L5: OSBPL3; NbExp=3; IntAct=EBI-11955057, EBI-1051317;
CC Q8N8B7-2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-11955057, EBI-79165;
CC Q8N8B7-2; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-11955057, EBI-742388;
CC Q8N8B7-2; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-11955057, EBI-302345;
CC Q8N8B7-2; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-11955057, EBI-10171633;
CC Q8N8B7-2; P49023-2: PXN; NbExp=3; IntAct=EBI-11955057, EBI-11954250;
CC Q8N8B7-2; Q9H4P4: RNF41; NbExp=3; IntAct=EBI-11955057, EBI-2130266;
CC Q8N8B7-2; Q92622: RUBCN; NbExp=3; IntAct=EBI-11955057, EBI-2952709;
CC Q8N8B7-2; Q9P2F8-2: SIPA1L2; NbExp=3; IntAct=EBI-11955057, EBI-10326741;
CC Q8N8B7-2; O60504: SORBS3; NbExp=3; IntAct=EBI-11955057, EBI-741237;
CC Q8N8B7-2; O43805: SSNA1; NbExp=3; IntAct=EBI-11955057, EBI-2515299;
CC Q8N8B7-2; Q13033-2: STRN3; NbExp=3; IntAct=EBI-11955057, EBI-1053876;
CC Q8N8B7-2; Q16623: STX1A; NbExp=3; IntAct=EBI-11955057, EBI-712466;
CC Q8N8B7-2; Q12846: STX4; NbExp=3; IntAct=EBI-11955057, EBI-744942;
CC Q8N8B7-2; Q15633: TARBP2; NbExp=3; IntAct=EBI-11955057, EBI-978581;
CC Q8N8B7-2; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-11955057, EBI-3923210;
CC Q8N8B7-2; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-11955057, EBI-741515;
CC Q8N8B7-2; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11955057, EBI-11741437;
CC Q8N8B7-2; Q7Z6W1: TMCO2; NbExp=3; IntAct=EBI-11955057, EBI-12807858;
CC Q8N8B7-2; Q15025: TNIP1; NbExp=3; IntAct=EBI-11955057, EBI-357849;
CC Q8N8B7-2; Q96KP6: TNIP3; NbExp=3; IntAct=EBI-11955057, EBI-2509913;
CC Q8N8B7-2; Q12933: TRAF2; NbExp=3; IntAct=EBI-11955057, EBI-355744;
CC Q8N8B7-2; P36406: TRIM23; NbExp=3; IntAct=EBI-11955057, EBI-740098;
CC Q8N8B7-2; P14373: TRIM27; NbExp=5; IntAct=EBI-11955057, EBI-719493;
CC Q8N8B7-2; Q13049: TRIM32; NbExp=3; IntAct=EBI-11955057, EBI-742790;
CC Q8N8B7-2; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-11955057, EBI-17716262;
CC Q8N8B7-2; O94972: TRIM37; NbExp=3; IntAct=EBI-11955057, EBI-741602;
CC Q8N8B7-2; Q8WV44: TRIM41; NbExp=5; IntAct=EBI-11955057, EBI-725997;
CC Q8N8B7-2; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-11955057, EBI-2130429;
CC Q8N8B7-2; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-11955057, EBI-11524408;
CC Q8N8B7-2; Q495M9: USH1G; NbExp=3; IntAct=EBI-11955057, EBI-8601749;
CC Q8N8B7-2; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-11955057, EBI-739895;
CC Q8N8B7-2; Q08AM6: VAC14; NbExp=3; IntAct=EBI-11955057, EBI-2107455;
CC Q8N8B7-2; P61758: VBP1; NbExp=3; IntAct=EBI-11955057, EBI-357430;
CC Q8N8B7-2; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-11955057, EBI-2799833;
CC Q8N8B7-2; O43829: ZBTB14; NbExp=3; IntAct=EBI-11955057, EBI-10176632;
CC Q8N8B7-2; O15060: ZBTB39; NbExp=3; IntAct=EBI-11955057, EBI-9995672;
CC Q8N8B7-2; Q96C00: ZBTB9; NbExp=3; IntAct=EBI-11955057, EBI-395708;
CC Q8N8B7-2; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-11955057, EBI-8656416;
CC Q8N8B7-2; Q9P0L1-2: ZKSCAN7; NbExp=3; IntAct=EBI-11955057, EBI-10698225;
CC Q8N8B7-2; Q8N554: ZNF276; NbExp=3; IntAct=EBI-11955057, EBI-750821;
CC Q8N8B7-2; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11955057, EBI-625509;
CC Q8N8B7-2; Q9BS34: ZNF670; NbExp=3; IntAct=EBI-11955057, EBI-745276;
CC Q8N8B7-2; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-11955057, EBI-4395732;
CC Q8N8B7-2; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11955057, EBI-11962574;
CC Q8N8B7-2; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11955057, EBI-527853;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N8B7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8B7-2; Sequence=VSP_039895;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04930.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK097032; BAC04930.1; ALT_INIT; mRNA.
DR EMBL; AK315599; BAG37970.1; -; mRNA.
DR EMBL; DC344354; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC079383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020095; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS48081.1; -. [Q8N8B7-2]
DR CCDS; CCDS75954.1; -. [Q8N8B7-1]
DR RefSeq; NP_001284492.1; NM_001297563.1. [Q8N8B7-1]
DR RefSeq; NP_001284493.1; NM_001297564.1. [Q8N8B7-1]
DR RefSeq; XP_016884805.1; XM_017029316.1. [Q8N8B7-2]
DR RefSeq; XP_016884806.1; XM_017029317.1. [Q8N8B7-1]
DR RefSeq; XP_016884807.1; XM_017029318.1. [Q8N8B7-1]
DR RefSeq; XP_016884808.1; XM_017029319.1. [Q8N8B7-1]
DR AlphaFoldDB; Q8N8B7; -.
DR SMR; Q8N8B7; -.
DR BioGRID; 127996; 143.
DR IntAct; Q8N8B7; 127.
DR STRING; 9606.ENSP00000440038; -.
DR iPTMnet; Q8N8B7; -.
DR PhosphoSitePlus; Q8N8B7; -.
DR BioMuta; TCEANC; -.
DR DMDM; 117949797; -.
DR EPD; Q8N8B7; -.
DR jPOST; Q8N8B7; -.
DR MassIVE; Q8N8B7; -.
DR PaxDb; Q8N8B7; -.
DR PeptideAtlas; Q8N8B7; -.
DR PRIDE; Q8N8B7; -.
DR ProteomicsDB; 72395; -. [Q8N8B7-1]
DR ProteomicsDB; 72396; -. [Q8N8B7-2]
DR Antibodypedia; 400; 14 antibodies from 7 providers.
DR DNASU; 170082; -.
DR Ensembl; ENST00000380600.1; ENSP00000369974.1; ENSG00000176896.8. [Q8N8B7-1]
DR Ensembl; ENST00000544987.2; ENSP00000440038.2; ENSG00000176896.8. [Q8N8B7-2]
DR GeneID; 170082; -.
DR KEGG; hsa:170082; -.
DR UCSC; uc064yao.1; human. [Q8N8B7-1]
DR CTD; 170082; -.
DR DisGeNET; 170082; -.
DR GeneCards; TCEANC; -.
DR HGNC; HGNC:28277; TCEANC.
DR HPA; ENSG00000176896; Low tissue specificity.
DR neXtProt; NX_Q8N8B7; -.
DR OpenTargets; ENSG00000176896; -.
DR VEuPathDB; HostDB:ENSG00000176896; -.
DR eggNOG; KOG1105; Eukaryota.
DR GeneTree; ENSGT00940000162067; -.
DR HOGENOM; CLU_890113_0_0_1; -.
DR InParanoid; Q8N8B7; -.
DR OMA; FNCKVTV; -.
DR OrthoDB; 1579101at2759; -.
DR PhylomeDB; Q8N8B7; -.
DR TreeFam; TF314970; -.
DR PathwayCommons; Q8N8B7; -.
DR SignaLink; Q8N8B7; -.
DR BioGRID-ORCS; 170082; 10 hits in 711 CRISPR screens.
DR GenomeRNAi; 170082; -.
DR Pharos; Q8N8B7; Tdark.
DR PRO; PR:Q8N8B7; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8N8B7; protein.
DR Bgee; ENSG00000176896; Expressed in granulocyte and 104 other tissues.
DR ExpressionAtlas; Q8N8B7; baseline and differential.
DR Genevisible; Q8N8B7; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.472.30; -; 1.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR035100; TF_IIS-typ.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR Pfam; PF08711; Med26; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR PIRSF; PIRSF006704; TF_IIS; 1.
DR SMART; SM00510; TFS2M; 1.
DR SUPFAM; SSF46942; SSF46942; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..351
FT /note="Transcription elongation factor A N-terminal and
FT central domain-containing protein"
FT /id="PRO_0000259659"
FT DOMAIN 5..82
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT DOMAIN 173..289
FT /note="TFIIS central"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT REGION 86..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MISAHRKLCLPGSSNSPASAFRVAGTTAVKM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039895"
FT VARIANT 163
FT /note="S -> L (in dbSNP:rs2361159)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_028970"
SQ SEQUENCE 351 AA; 40245 MW; C48E135BCDC27B9E CRC64;
MSDKNQIAAR ASLIEQLMSK RNFEDLGNHL TELETIYVTK EHLQETDVVR AVYRVLKNCP
SVALKKKAKC LLSKWKAVYK QTHSKARNSP KLFPVRGNKE ENSGPSHDPS QNETLGICSS
NSLSSQDVAK LSEMIVPENR AIQLKPKEEH FGDGDPESTG KRSSELLDPT TPMRTKCIEL
LYAALTSSST DQPKADLWQN FAREIEEHVF TLYSKNIKKY KTCIRSKVAN LKNPRNSHLQ
QNLLSGTTSP REFAEMTVME MANKELKQLR ASYTESCIQE HYLPQVIDGT QTNKIKCRRC
EKYNCKVTVI DRGTLFLPSW VRNSNPDEQM MTYVICNECG EQWYHSKWVC W
