TEANC_MOUSE
ID TEANC_MOUSE Reviewed; 359 AA.
AC Q3US16; Q6NXL9; Q8BY92;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transcription elongation factor A N-terminal and central domain-containing protein;
DE AltName: Full=TFIIS central domain-containing protein 1;
GN Name=Tceanc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=BC067008; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK041519; BAC30970.1; -; mRNA.
DR EMBL; AK140929; BAE24521.1; -; mRNA.
DR EMBL; BC067008; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS53249.1; -.
DR RefSeq; NP_001007578.2; NM_001007577.2.
DR RefSeq; XP_006528926.1; XM_006528863.3.
DR RefSeq; XP_011246129.1; XM_011247827.2.
DR AlphaFoldDB; Q3US16; -.
DR SMR; Q3US16; -.
DR BioGRID; 232829; 4.
DR STRING; 10090.ENSMUSP00000107806; -.
DR iPTMnet; Q3US16; -.
DR PhosphoSitePlus; Q3US16; -.
DR MaxQB; Q3US16; -.
DR PaxDb; Q3US16; -.
DR PRIDE; Q3US16; -.
DR ProteomicsDB; 259371; -.
DR Antibodypedia; 400; 14 antibodies from 7 providers.
DR DNASU; 245695; -.
DR Ensembl; ENSMUST00000112188; ENSMUSP00000107806; ENSMUSG00000051224.
DR Ensembl; ENSMUST00000180322; ENSMUSP00000136691; ENSMUSG00000051224.
DR GeneID; 245695; -.
DR KEGG; mmu:245695; -.
DR UCSC; uc009uwv.1; mouse.
DR CTD; 170082; -.
DR MGI; MGI:2685236; Tceanc.
DR VEuPathDB; HostDB:ENSMUSG00000051224; -.
DR eggNOG; KOG1105; Eukaryota.
DR GeneTree; ENSGT00940000162067; -.
DR HOGENOM; CLU_890113_0_0_1; -.
DR InParanoid; Q3US16; -.
DR OMA; FNCKVTV; -.
DR OrthoDB; 1579101at2759; -.
DR PhylomeDB; Q3US16; -.
DR TreeFam; TF314970; -.
DR BioGRID-ORCS; 245695; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Tceanc; mouse.
DR PRO; PR:Q3US16; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q3US16; protein.
DR Bgee; ENSMUSG00000051224; Expressed in placenta labyrinth and 168 other tissues.
DR ExpressionAtlas; Q3US16; baseline and differential.
DR Genevisible; Q3US16; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.472.30; -; 1.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR035100; TF_IIS-typ.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR Pfam; PF08711; Med26; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR PIRSF; PIRSF006704; TF_IIS; 1.
DR SMART; SM00510; TFS2M; 1.
DR SUPFAM; SSF46942; SSF46942; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..359
FT /note="Transcription elongation factor A N-terminal and
FT central domain-containing protein"
FT /id="PRO_0000259661"
FT DOMAIN 1..82
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT DOMAIN 182..298
FT /note="TFIIS central"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT REGION 84..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 40635 MW; 060A97CCCB4C557F CRC64;
MSDKNQIIAR ASLIEQLVSK RYFEDIGKQL TELEMIYVSK EHLQETDVVR AVYRVLKNCP
SVTLKKKAKC LLAKWRGFYK STHCKPRQSP KVLHTNANKE ESAAVSQDVS QDETSGSSHS
EIMGLCSSLS RLLPQDAAKP AAAIGSESST AQMEINEGYL KGDDSECTRK SSGVFQGTLV
SVRSKCVELL YTALASSCTD HTEVHIWQNL AREIEEHIFT LHSNNIKKYK TSIRSKVANL
KNPRNFHLQQ NFLSGTMSAR EFAEMSVLDM ASQELKQLRA SYTESSIQEH CLPQSVDGTW
TNKIKCRRCD KYNCKVTVIA RGTLFLPSWV QNSNPDEQMT YVICNECGEQ WYHNNWVCL
