TEA_DROME
ID TEA_DROME Reviewed; 1876 AA.
AC E1JH25; A1Z817;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Protein telomere ends associated {ECO:0000303|PubMed:27835648};
GN Name=tea {ECO:0000303|PubMed:27835648, ECO:0000312|FlyBase:FBgn0285892};
GN ORFNames=CG30007 {ECO:0000312|FlyBase:FBgn0285892};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AEX98013.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=27835648; DOI=10.1371/journal.pgen.1006435;
RA Zhang Y., Zhang L., Tang X., Bhardwaj S.R., Ji J., Rong Y.S.;
RT "MTV, an ssDNA Protecting Complex Essential for Transposon-Based Telomere
RT Maintenance in Drosophila.";
RL PLoS Genet. 12:E1006435-E1006435(2016).
CC -!- FUNCTION: Protects telomeres from fusion. Likely to function as a
CC component of the MTV complex along with moi and ver. The complex binds
CC single-stranded DNA in a sequence-independent manner and can protect it
CC from DNA degradation. {ECO:0000269|PubMed:27835648}.
CC -!- SUBUNIT: Found in the MTV (moi-tea-ver) complex, composed of tea and
CC the telomere capping proteins moi and ver. In the complex, tea may
CC function to recruit moi and ver to DNA. {ECO:0000269|PubMed:27835648}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000269|PubMed:27835648}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=C {ECO:0000312|FlyBase:FBgn0285892};
CC IsoId=E1JH25-1; Sequence=Displayed;
CC Name=B {ECO:0000312|FlyBase:FBgn0285892};
CC IsoId=E1JH25-2; Sequence=VSP_058974, VSP_058975;
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DR EMBL; AE013599; AAF58876.2; -; Genomic_DNA.
DR EMBL; AE013599; ACZ94382.1; -; Genomic_DNA.
DR EMBL; BT133093; AEX98013.1; -; mRNA.
DR RefSeq; NP_001163105.1; NM_001169634.2. [E1JH25-1]
DR RefSeq; NP_610533.1; NM_136689.3.
DR AlphaFoldDB; E1JH25; -.
DR STRING; 7227.FBpp0290143; -.
DR EnsemblMetazoa; FBtr0088381; FBpp0087469; FBgn0285892.
DR EnsemblMetazoa; FBtr0300919; FBpp0290141; FBgn0285892. [E1JH25-1]
DR EnsemblMetazoa; FBtr0300920; FBpp0290142; FBgn0285892. [E1JH25-2]
DR GeneID; 36027; -.
DR KEGG; dme:Dmel_CG30007; -.
DR UCSC; CG30007-RB; d. melanogaster.
DR CTD; 36027; -.
DR FlyBase; FBgn0285892; tea.
DR VEuPathDB; VectorBase:FBgn0285892; -.
DR eggNOG; KOG3071; Eukaryota.
DR OMA; LKSTIWR; -.
DR BioGRID-ORCS; 36027; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 36027; -.
DR PRO; PR:E1JH25; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0285892; Expressed in saliva-secreting gland and 25 other tissues.
DR ExpressionAtlas; E1JH25; baseline and differential.
DR Genevisible; E1JH25; DM.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome; DNA-binding; Reference proteome;
KW Telomere.
FT CHAIN 1..1876
FT /note="Protein telomere ends associated"
FT /id="PRO_0000440616"
FT REGION 333..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1679..1699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1685..1691
FT /note="VNKEDHP -> TRRRSRK (in isoform B)"
FT /id="VSP_058974"
FT VAR_SEQ 1692..1876
FT /note="Missing (in isoform B)"
FT /id="VSP_058975"
FT CONFLICT 786
FT /note="K -> NR (in Ref. 3; AEX98013)"
FT /evidence="ECO:0000305"
FT CONFLICT 934
FT /note="K -> KS (in Ref. 3; AEX98013)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1876 AA; 211809 MW; B812F2C1C46F20EF CRC64;
MYPVSFAAFQ KLIVNLSEIA SELKTANGDN RTLVEWSRWY YKEFYRNPSI RARFPVKVAP
CPRRTRDNLL KVPEPGGISQ NDVANVAAAG PSQVEQPEVL VEGSQLTTLA ETAKSHDAVE
GVAVECKPSG SESPDVIVNV ERCGAFIFPV SFDVFLQCIN KMLLFKKIVR SIEHCLVLLS
DDERRLLTLQ RFYNRFYMYP EKRSPTNIFN ATTEIPLEKL LESGKPLDKK AVKTVAELTA
MKSLTKNSIV SFEVFKKNMA NLSDIVEQMR QLDANYASKD VQECALDYYL AFYITPRIRY
KYAYKLKPCT STFKACMLSI LGKDIAEKLR KSLPQLANPS PGLDSRRPNT SYITESKGSL
GSQNTSGSSQ IQTSPSMEVA HEPSEGLSQL ATLSPENCAA GAISTTEGLS SSHNTLETFE
NQANLRNDAN KLSRCMPALA SPERHLHSSK APEKSSEVLS PQVKPHQSKE VAEEQSDRAP
QLEIPPSGFE VPMSKTPESP ASKTRASDET PAKPEEITDS TDVYETSFVT DVEVDLKKHG
RFIFPVSLET FRQYINYDEI IRAILVNNHI KDEHQLSKLI SDPSHPQCKK FFRQFYNKFY
ARNDVRQRFK YKFNCPNPKM LAKLKQKAKP LDEKALFTMN RTDNAKAVNE SKSQVPFTPK
TTTENCPPNP ISLEMFKRHV SNLDDIVNEM QKCDEYKEKS KEEVIQDYYE GFYSGPDMRE
KFECRFKPCP SKKIRQLLSF PPKNKELPPK NPNCQVACTT ENLSDESCLQ SSRNVVRETQ
NITEEKPIAE HESIPSTRTP SSNDDKPGEE CPPYPVSLEL FKSHVSNLDD IANNMQKCVE
YRGKSKDEVI RDYYKGFYSG PEMREKFACR FKPCTGHILQ QLLSYPGKNV NDCLQETDCL
ATCTTRTPLK ESCLQSKSEM SLPVRRNALE ILMKRKRTKV AKEAISSKPM TTQNTSQFQP
EPFPEDALVV PEDVTTNQGT QPLELQHELE VTEPIKDYIQ LNAERLYELS SKLKIGWNYT
AHNFLDKLFK GINCPVTQAF LEEQYKRYSV STGHIVANTI AAEENEPQLS SNSVDIESVC
TAQTTATDTQ ATEMHTIPKA LDQSSEPTKE SSSVNLNNNL ESPAKIKMIH AESSNNSRNS
TNRPNTEIEA GSTKILEDGA RVTTEGNSEN ENSSVEKKEN QFLLERAKEI FFAEGSKDHN
LKYLICTSEG LMRTIWRILY QLDLQEFSYY TSIHDGEDLY KSEDNLHLCF RHVVDHGNWP
VNLCVLLPRL KHLLHSKGVQ LDRLNLSKIS PKIFSPWELG TYSDFDQIVA QEYIHRTGEE
IEDVVKLCQE REKLYACCWA HNQWLPRAPQ IANETLNAEL GEVEPVIERI LLKKICGVKD
GDENKPTEIV SIPSSPSTVC SRISTQPAED KLSQQPSQLN SLNFVDVTGV ELASQVPQMV
VDPLVSNQIE ETSQVPETQY DAPASLQMAS VKQEPISFLN NQRAFCDSEK CQWEHINPEE
QTIDLDSTES DGPSLSCFAI QNQNSEDQIH FILEDSVHAE NHDYVKKTEV PKSTDPAQLG
TNVNTLSVRS MPACQVSVIP KKRQAASPRL NSKRMKLMND KVPQLRHEFQ PLPMGVKVVQ
SKALILPDSQ NIRTSQTAKT KPTESPPHHQ VNITPSQEFA VGNTLLECSE LQGLLDSNDV
NDGKVNKEDH PVSGSACTSK RLAASSPQSS VIYRDLELFS FYKSLTLEQI IKYRIEGPLP
GATYQKALVK INDKLCNVRG PLISSLFPYL SSTLRSDLEL VLHDLGEFFY KRSWPAHTDA
TVDFRKRVLF VFMNLSPRFA PFSIKFDNES REWGTCIEAN VGDKSLDQRD TTFNAEELIK
PNILNSIEQL KCKLVT
