ID   TEBA_STYMT              Reviewed;         493 AA.
AC   P29550;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Telomere-binding protein subunit alpha;
GN   Name=STY56V;
GN   and
GN   Name=STY56I;
OS   Stylonychia mytilus (Ciliate).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Stylonychinae; Stylonychia.
OX   NCBI_TaxID=5950;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1945829; DOI=10.1093/nar/19.20.5515;
RA   Fang G., Cech T.R.;
RT   "Molecular cloning of telomere-binding protein genes from Stylonychia
RT   mytilis.";
RL   Nucleic Acids Res. 19:5515-5518(1991).
CC   -!- FUNCTION: May function as protective capping of the single-stranded
CC       telomeric overhang. May also participate in telomere length regulation
CC       during DNA replication.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, telomere.
CC   -!- MISCELLANEOUS: The sequence of STY56V is shown. STY56I differs in only
CC       one position.
CC   -!- SIMILARITY: Belongs to the telombin family. {ECO:0000305}.
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DR   EMBL; X61749; CAA43888.1; -; Genomic_DNA.
DR   AlphaFoldDB; P29550; -.
DR   SMR; P29550; -.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:InterPro.
DR   GO; GO:0016233; P:telomere capping; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 3.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR028389; POT1.
DR   InterPro; IPR011564; Telomer_end-bd_POT1/Cdc13.
DR   InterPro; IPR003415; Telomere-bd_alpha.
DR   PANTHER; PTHR14513; PTHR14513; 1.
DR   Pfam; PF02765; POT1; 2.
DR   PIRSF; PIRSF015848; TEBP_alpha; 1.
DR   SMART; SM00976; Telo_bind; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleus; Telomere.
FT   CHAIN           1..493
FT                   /note="Telomere-binding protein subunit alpha"
FT                   /id="PRO_0000121736"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         429
FT                   /note="V -> I (in STY56I)"
SQ   SEQUENCE   493 AA;  56098 MW;  B49002984363C5AA CRC64;
     MSSAKRSTSR VSKKKAAPAK DGAPKKREQS TRYKYVELNK ASLTSAEAQH FYGVVIDATF
     PYKTNQERYI CSLKVVDPSL YLKSQKGTGD ASDYATLVLY AKRFEDLPII HRIGDIIRVH
     RATLRLYNGQ RQFNANVFYN SSWALFSTDK KSALQEIGGQ EPASDLTPFA FSGKNYTFEK
     SEAALLQNIR KWAVQYFQQY NVISSDMFTP LNKAQAQKGD FDVVAKILQV FELDEYTNEL
     KLKDQSGQVF YTLALKLKFP HLRAGEVVRI RSATYDETST QKKVLLLSHY SNIVTFVSAS
     KLAKEVKAKV TDDKSVEKAA LKQDVSLSAV VLTEVDKKHA GLPTHSLQDL FHNADTDKEI
     SSKDTFRTQF YITRVEPVDV KEWVKSYDRK TKKPSSHKGA GAKGGENIFQ VQFLVKDAST
     QLNNNTYRVL LYTQDGLGAN FFNVKPDNLY KNNDARKKLE EYNELLTKFN SYVDAVVERR
     NGFYFIKDTR IIF