ID   TEBP_CHICK              Reviewed;         146 AA.
AC   Q90955;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Prostaglandin E synthase 3;
DE            EC=5.3.99.3;
DE   AltName: Full=Cytosolic prostaglandin E2 synthase;
DE            Short=cPGES;
DE   AltName: Full=Hsp90 co-chaperone;
DE   AltName: Full=Progesterone receptor complex p23;
DE   AltName: Full=Telomerase-binding protein p23;
DE   Flags: Fragment;
GN   Name=PTGES3; Synonyms=TEBP;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Brain;
RX   PubMed=8114727; DOI=10.1128/mcb.14.3.1956-1963.1994;
RA   Johnson J.L., Beito T.G., Krco C.J., Toft D.O.;
RT   "Characterization of a novel 23-kilodalton protein of unactive progesterone
RT   receptor complexes.";
RL   Mol. Cell. Biol. 14:1956-1963(1994).
CC   -!- FUNCTION: Molecular chaperone. {ECO:0000250|UniProtKB:Q15185}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=prostaglandin H2 = prostaglandin E2; Xref=Rhea:RHEA:12893,
CC         ChEBI:CHEBI:57405, ChEBI:CHEBI:606564; EC=5.3.99.3;
CC   -!- PATHWAY: Lipid metabolism; prostaglandin biosynthesis.
CC   -!- SUBUNIT: Binds to telomerase (By similarity). Binds to the progesterone
CC       receptor (PubMed:8114727). {ECO:0000250|UniProtKB:Q15185,
CC       ECO:0000269|PubMed:8114727}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}.
CC   -!- SIMILARITY: Belongs to the p23/wos2 family. {ECO:0000305}.
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DR   EMBL; L24898; AAA17491.1; -; mRNA.
DR   RefSeq; NP_001263235.1; NM_001276306.2.
DR   AlphaFoldDB; Q90955; -.
DR   SMR; Q90955; -.
DR   PaxDb; Q90955; -.
DR   GeneID; 100859133; -.
DR   KEGG; gga:100859133; -.
DR   CTD; 10728; -.
DR   VEuPathDB; HostDB:geneid_100859133; -.
DR   InParanoid; Q90955; -.
DR   OrthoDB; 1461729at2759; -.
DR   PhylomeDB; Q90955; -.
DR   TreeFam; TF315077; -.
DR   UniPathway; UPA00662; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IDA:AgBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; ISS:AgBase.
DR   GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR   GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR   GO; GO:0033142; F:nuclear progesterone receptor binding; IPI:AgBase.
DR   GO; GO:0050220; F:prostaglandin-E synthase activity; ISS:AgBase.
DR   GO; GO:0003720; F:telomerase activity; ISS:AgBase.
DR   GO; GO:0051082; F:unfolded protein binding; ISS:AgBase.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; IBA:GO_Central.
DR   GO; GO:0001516; P:prostaglandin biosynthetic process; ISS:AgBase.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:1905323; P:telomerase holoenzyme complex assembly; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR045250; p23-like.
DR   PANTHER; PTHR22932; PTHR22932; 1.
DR   Pfam; PF04969; CS; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS51203; CS; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis;
KW   Fatty acid metabolism; Isomerase; Lipid biosynthesis; Lipid metabolism;
KW   Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome.
FT   CHAIN           <1..146
FT                   /note="Prostaglandin E synthase 3"
FT                   /id="PRO_0000218954"
FT   DOMAIN          <1..76
FT                   /note="CS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT   REGION          110..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..146
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   146 AA;  16869 MW;  6780E9E0ED00704C CRC64;
     VFIEFCVEDS KDVNVNFEKS KLTFSCLGGS DNFKHLNEID LFNNIDPNES KHKRTDRSIL
     CCLRKGESGQ AWPRLTKERA KLNWLSVDFN NWKDWEDDSD EDMSNFDRFS EMMNNMGGDD
     DVDLPEVDGA DDDSPDSDDE KMPDLE