ID   TEB_EUPCR               Reviewed;         446 AA.
AC   Q06184;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Telomere-binding protein 51 kDa subunit;
OS   Euplotes crassus.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Hypotrichia; Euplotida; Euplotidae; Moneuplotes.
OX   NCBI_TaxID=5936;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=1480483; DOI=10.1093/nar/20.24.6621;
RA   Wang W., Skopp R., Scofield M., Price C.;
RT   "Euplotes crassus has genes encoding telomere-binding proteins and
RT   telomere-binding protein homologs.";
RL   Nucleic Acids Res. 20:6621-6629(1992).
CC   -!- FUNCTION: May function as protective capping of the single-stranded
CC       telomeric overhang. May also participate in telomere length regulation
CC       during DNA replication. Binds specifically to the T4G4-containing
CC       extension on the 3'strand and protects this region of the telomere from
CC       nuclease digestion and chemical modification.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, telomere.
CC   -!- SIMILARITY: Belongs to the telombin family. {ECO:0000305}.
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DR   EMBL; M96818; AAA29127.1; -; Genomic_DNA.
DR   PIR; S35524; S35524.
DR   AlphaFoldDB; Q06184; -.
DR   SMR; Q06184; -.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:InterPro.
DR   GO; GO:0016233; P:telomere capping; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 3.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR028389; POT1.
DR   InterPro; IPR011564; Telomer_end-bd_POT1/Cdc13.
DR   InterPro; IPR003415; Telomere-bd_alpha.
DR   PANTHER; PTHR14513; PTHR14513; 1.
DR   Pfam; PF02765; POT1; 1.
DR   PIRSF; PIRSF015848; TEBP_alpha; 1.
DR   SMART; SM00976; Telo_bind; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Nucleus; Telomere.
FT   CHAIN           1..446
FT                   /note="Telomere-binding protein 51 kDa subunit"
FT                   /id="PRO_0000121733"
SQ   SEQUENCE   446 AA;  51544 MW;  EF702F1E161990E3 CRC64;
     MPKQKAAKKD HYQYSDLSSI KKEGEEDQYH FYGVVIDASF PYKGEKRYVV TCKVADPSSV
     AKGGKLNTVN VVFFSQNFED LPIIQRVGDI VRVHRARLQH YNDAKQLNVN MYYRSSWCLF
     IGNDKEAPLE PKVENEDGTN NYFSYTPYNF SGKSFTQEGH ETKILKDLKK WSKDYFSNND
     VVEQVKKADI ETAMKNKTDF DLLAKVTEIS DNDQYTNTVS LNDSTGQTWT GHLFKRKFPH
     LVKGDVLRIK SVSAKEDNSL IFSSHSNILK FFSFSSIHKK LKSSISSDTH IKTCVTKIDK
     AAHNKMDITP LKKLFFNPKK SEKLFRSQFS VLKVDTKNLE DYVGAFDGKK WHSYKGKKTP
     KDAELRWNIK LIVTDYKNQQ DDKAYMIHLD DNSFFKGINP ANWSNAATKK KAEKAFSVLT
     NNKVNYVDAI LERDKKNYHI RHTQFK