TECRL_BOVIN
ID TECRL_BOVIN Reviewed; 363 AA.
AC Q3SZ89;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Trans-2,3-enoyl-CoA reductase-like;
DE EC=1.3.1.-;
DE AltName: Full=Steroid 5-alpha-reductase 2-like 2 protein;
GN Name=TECRL; Synonyms=SRD5A2L2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q5HYJ1}.
CC -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC103046; AAI03047.1; -; mRNA.
DR RefSeq; NP_001073793.1; NM_001080324.2.
DR AlphaFoldDB; Q3SZ89; -.
DR SMR; Q3SZ89; -.
DR STRING; 9913.ENSBTAP00000034462; -.
DR PaxDb; Q3SZ89; -.
DR Ensembl; ENSBTAT00000034572; ENSBTAP00000034462; ENSBTAG00000024826.
DR GeneID; 616643; -.
DR KEGG; bta:616643; -.
DR CTD; 253017; -.
DR VEuPathDB; HostDB:ENSBTAG00000024826; -.
DR VGNC; VGNC:35731; TECRL.
DR eggNOG; KOG1639; Eukaryota.
DR GeneTree; ENSGT00950000182886; -.
DR HOGENOM; CLU_059260_1_0_1; -.
DR InParanoid; Q3SZ89; -.
DR OMA; RQVSWTT; -.
DR OrthoDB; 720263at2759; -.
DR TreeFam; TF300908; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000024826; Expressed in cardiac ventricle and 29 other tissues.
DR ExpressionAtlas; Q3SZ89; baseline.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR GO; GO:0042761; P:very long-chain fatty acid biosynthetic process; IBA:GO_Central.
DR InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR InterPro; IPR039357; SRD5A/TECR.
DR PANTHER; PTHR10556; PTHR10556; 1.
DR Pfam; PF02544; Steroid_dh; 1.
DR PROSITE; PS50244; S5A_REDUCTASE; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Oxidoreductase; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..363
FT /note="Trans-2,3-enoyl-CoA reductase-like"
FT /id="PRO_0000317712"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BFZ1"
SQ SEQUENCE 363 AA; 42058 MW; CA5CBF8F9E124137 CRC64;
MFKRHKSLAS ERRRELISRG ATRSILKDDM KNFHFLSQFI LSAGPLKSTS AVKHSKTIHF
EIEILDAQTK KQICIVDKVT QKSTIHDVKQ KFHKACPQWY PSRVGLQLER GGPFLKDNLT
IQSVAASSIV TLYFTDLGQQ VSWTTVFLAE YTGPLLIYLL FYLRIPYIYN MKESSRRLCH
PVVHLACFCH CIHYIRYLLE TLFVHKVSSG HTSLKNLLKS CAFYWGFTSW IAYYINHPRY
TPPSFGYRQV AISAINFLIC EAGNHFINVV LSHPSHTGNN ACFPSPNYNP FTWMFFLVSC
PNYTYEIGSW ISFTIMTQTL PVGIFTLLMS IQMSLWAKKK HKIYLKKFSS YMHRKSAMIP
FIL
